OWNERSHIP PROFILE

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 217 1,410.23 97.45 79,991,502
Mutual Fund 187 352.87 20.03 16,443,968
Insider 14 23.93 1.79 1,471,776

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 115 426.17 26.74 21,948,272
Sellers 89 -135.58 10.29 -8,442,839
Net -- 290.59 16.45 13,505,433

Concentration

Value ($MM) % O/S Shares
Total Inst. 1,410.23 97.45 79,991,502
Top 10 Inst. 790.31 53.03 43,532,102
Top 20 Inst. 1,076.45 74.90 61,485,262
Top 50 Inst. 1,317.10 91.28 74,930,813

Style

Holders Value ($MM) % Inst Shares Shares
Growth 37 56.34 3.82 3,136,989
Aggressive Growth 2 0.78 0.05 43,412
Core Growth 30 54.38 3.69 3,028,869
Growth 5 1.19 0.08 64,708
Income 5 5.76 0.39 321,230
Income Value 1 3.11 0.21 175,144
Yield 4 2.65 0.18 146,086
Index 24 249.24 17.01 13,960,411
Other 79 984.49 63.46 52,090,587
Broker Dealer 14 9.24 0.63 520,239
GARP 27 120.58 7.94 6,518,909
Hedge Fund 34 579.27 37.62 30,884,442
Specialty 1 0.20 0.01 8,360
VC/Private Equi 3 275.21 17.25 14,158,637
Value 22 34.43 2.42 1,984,420
Core Value 18 29.88 2.11 1,728,740
Deep Value 4 4.55 0.31 255,680

Location: Global Region

Holders % O/S Shares Share Change
North America 161 88.89 72,967,681 13,240,911
Europe 30 3.03 2,491,153 2,165,613
Asia 5 0.12 101,465 92,442
Africa 1 0.11 89,200 --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
RA Capital Management, LLC 6,196,143 7.55 546,259 9/30/18
venBio Select Advisor LLC 5,301,718 6.46 -393,482 9/30/18
Magnetar Capital Partners LP 5,214,176 6.35 5,214,176 11/1/18
BlackRock Institutional Trust Company, N.A. 4,904,718 5.97 55,391 9/30/18
VHCP Management, LLC 4,811,302 5.86 511,302 9/30/18
Sanderling Ventures 4,045,617 4.93 -- 11/14/18
The Vanguard Group, Inc. 3,524,390 4.29 394,259 9/30/18
Deerfield Management Company, L.P. 3,514,084 4.28 1,189,785 9/30/18
T. Rowe Price Associates, Inc. 3,261,891 3.97 642,082 9/30/18
Pension Fund of the Christian Church 2,758,063 3.36 -624,615 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
T. Rowe Price Health Sciences Fund 2,236,521 2.72 2,236,521 9/30/18
Vanguard Total Stock Market Index Fund 1,847,385 2.25 32,100 10/31/18
iShares Russell 2000 ETF 1,465,918 1.79 33,445 11/30/18
Eventide Healthcare & Life Sciences Fund 1,314,000 1.60 964,000 9/30/18
Vanguard Extended Market Index Fund 910,895 1.11 712 10/31/18
iShares NASDAQ Biotechnology ETF 897,047 1.09 81,500 11/30/18
IndexIQ Trust - IQ Merger Arbitrage ETF 693,238 0.84 693,238 11/30/18
iShares Russell 2000 Growth ETF 541,212 0.66 -29,202 11/30/18
Janus Henderson Global Life Sciences Fund (Ire) 442,442 0.54 442,442 9/30/18
TIAA-CREF Quant Small-Cap Equity Fund 364,000 0.44 -- 10/31/18

* Insider values reflect direct beneficial ownership.

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