OWNERSHIP PROFILE

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 218 1,315.08 95.65 78,519,224
Mutual Fund 192 299.57 19.08 15,661,020
Insider 14 23.93 1.79 1,471,776

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 117 401.51 25.73 21,119,810
Sellers 85 -134.29 10.25 -8,412,251
Net -- 267.22 15.48 12,707,559

Concentration

Value ($MM) % O/S Shares
Total Inst. 1,315.08 95.65 78,519,224
Top 10 Inst. 720.31 52.30 42,932,102
Top 20 Inst. 1,006.45 74.17 60,885,262
Top 50 Inst. 1,229.53 89.79 73,706,726

Style

Holders Value ($MM) % Inst Shares Shares
Growth 37 55.95 3.81 3,125,808
Aggressive Growth 2 0.79 0.05 44,446
Core Growth 30 54.27 3.69 3,028,869
Growth 5 0.89 0.06 52,493
Income 5 5.76 0.39 321,230
Income Value 1 3.11 0.21 175,144
Yield 4 2.65 0.18 146,086
Index 24 249.07 17.01 13,961,921
Other 77 896.23 61.82 50,745,493
Broker Dealer 14 9.24 0.63 520,239
GARP 26 103.00 7.07 5,799,815
Hedge Fund 33 578.13 37.59 30,858,442
Specialty 1 0.13 0.01 8,360
VC/Private Equi 3 205.73 16.52 13,558,637
Value 22 34.60 2.43 1,996,154
Core Value 19 30.08 2.12 1,741,694
Deep Value 3 4.52 0.31 254,460

Location: Global Region

Holders % O/S Shares Share Change
North America 159 87.17 71,554,251 12,335,984
Europe 31 3.14 2,579,499 2,149,596
Asia 5 0.12 99,986 91,505
Africa 1 0.11 89,200 --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
RA Capital Management, LLC 6,196,143 7.55 546,259 9/30/18
venBio Select Advisor LLC 5,301,718 6.46 -393,482 9/30/18
Magnetar Capital Partners LP 5,214,176 6.35 5,214,176 11/1/18
BlackRock Institutional Trust Company, N.A. 4,904,718 5.97 55,391 9/30/18
VHCP Management, LLC 4,211,302 5.13 -88,698 9/30/18
Sanderling Ventures 4,045,617 4.93 500,000 3/9/18
The Vanguard Group, Inc. 3,524,390 4.29 394,259 9/30/18
Deerfield Management Company, L.P. 3,514,084 4.28 1,189,785 9/30/18
T. Rowe Price Associates, Inc. 3,261,891 3.97 642,082 9/30/18
Pension Fund of the Christian Church 2,758,063 3.36 -624,615 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
T. Rowe Price Health Sciences Fund 2,236,521 2.72 2,236,521 9/30/18
Vanguard Total Stock Market Index Fund 1,815,285 2.21 195,956 9/30/18
iShares Russell 2000 ETF 1,439,491 1.75 7,018 10/31/18
iShares NASDAQ Biotechnology ETF 921,114 1.12 105,567 10/31/18
Vanguard Extended Market Index Fund 910,183 1.11 115,363 9/30/18
iShares Russell 2000 Growth ETF 537,169 0.65 -33,245 10/31/18
Fidelity Select Biotechnology Portfolio 504,315 0.61 -177,000 9/30/18
Invesco DWA Healthcare Momentum ETF 444,215 0.54 -308,986 8/31/18
Janus Henderson Global Life Sciences Fund (Ire) 442,442 0.54 442,442 9/30/18
Invesco DWA SmallCap Momentum ETF 366,802 0.45 366,802 9/30/18

* Insider values reflect direct beneficial ownership.

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