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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934 (Amendment No.          )

Filed by the Registrant ý

Filed by a Party other than the Registrant o

Check the appropriate box:

ý

 

Preliminary Proxy Statement

o

 

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

o

 

Definitive Proxy Statement

o

 

Definitive Additional Materials

o

 

Soliciting Material under §240.14a-12

 

Endocyte, Inc.

(Name of Registrant as Specified In Its Charter)

 

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

o

 

No fee required.

ý

 

Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
    (1)   Title of each class of securities to which transaction applies:
        Common stock, par value $0.001 per share, of Endocyte, Inc.
 
    (2)   Aggregate number of securities to which transaction applies:
        The maximum number of shares of common stock to which this transaction applies is estimated to be 88,872,846, which consists of (A) 82,088,638 shares of common stock issued and outstanding as of October 29, 2018, (B) 5,246,681 shares of common stock issuable upon exercise of options to purchase shares of common stock outstanding as of October 29, 2018, (C) 1,077,001 shares of common stock underlying restricted stock units outstanding as of October 29, 2018, (D) 442,000 shares of common stock issuable upon exercise of a warrant to purchase shares of common stock outstanding as of October 29, 2018, and (E) 18,526 shares of common stock that we estimate as the maximum number of shares that could be issued under the Endocyte, Inc. 2010 Employee Stock Purchase Plan prior to the completion of the merger.
 
    (3)   Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):
        Solely for the purposes of calculating the filing fee, the maximum aggregate value was determined based upon the sum of: (A) 82,088,638 shares of common stock multiplied by the merger consideration of $24.00 per share; (B) 5,246,681 shares of common stock issuable pursuant to options to purchase shares of common stock with an exercise price of less than $24.00 per share multiplied by $18.25 (the difference between the merger consideration of $24.00 per share and the weighted average exercise price of such options of $5.75 per share); (C) 1,077,001 shares of common stock underlying restricted stock units multiplied by the merger consideration of $24.00 per share; (D) 442,000 shares of common stock issuable upon exercise of an outstanding warrant to purchase shares of common stock multiplied by $22.61 per share (the difference between the merger consideration of $24.00 per share and the exercise price of such warrant of $1.39 per share); and (E) 18,526 shares of common stock that we estimate as the maximum number of shares that could be issued under the Endocyte, Inc. 2010 Employee Stock Purchase Plan prior to the completion of the merger, multiplied by the merger consideration of $24.00 per share. In accordance with Section 14(g) of the Securities Exchange Act of 1934, as amended, the filing fee was determined by multiplying $0.0001212 by the sum of the preceding sentence.
 
    (4)   Proposed maximum aggregate value of transaction:
        $2,102,165,508.25
 
    (5)   Total fee paid:
        $254,782.46
 

o

 

Fee paid previously with preliminary materials.

o

 

Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.

 

 

(1)

 

Amount Previously Paid:
        
 
    (2)   Form, Schedule or Registration Statement No.:
        
 
    (3)   Filing Party:
        
 
    (4)   Date Filed:
        
 

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PRELIMINARY PROXY STATEMENT—SUBJECT TO COMPLETION

ENDOCYTE, INC.
3000 Kent Avenue, Suite A1-100
West Lafayette, IN 47906
(765) 463-7175

[                        ], 2018

To Our Stockholders:

        You are invited to attend a special meeting of the stockholders of Endocyte, Inc., a Delaware corporation (which we refer to as "Endocyte," the "Company," "we," "our" or "us"), which we will hold at [                        ], on [                        ], [    ], 2018 at [                        ] local time. We refer to such meeting, including any adjournment or postponement thereof, as the "special meeting."

        At the special meeting, you will be asked to consider and vote on a proposal to adopt the Agreement and Plan of Merger (as it may be amended from time to time, the "merger agreement"), dated as of October 17, 2018, by and among Endocyte, Novartis AG, a company organized under the laws of Switzerland ("Novartis"), and Edinburgh Merger Corporation, a Delaware corporation and a wholly owned subsidiary of Novartis ("Merger Sub"), pursuant to which Merger Sub will be merged with and into Endocyte (the "merger"), the separate existence of Merger Sub will cease, and Endocyte will continue as the surviving corporation. You will also be asked to consider and vote on (1) a proposal to approve, on an advisory (non-binding) basis, certain compensation that may be paid or become payable to our named executive officers in connection with the merger; and (2) a proposal to adjourn the special meeting, if necessary or appropriate, including to solicit additional proxies if there are insufficient votes at the time of the special meeting to approve the proposal to adopt the merger agreement.

        If the merger agreement is adopted and the merger is completed, Endocyte will become a wholly owned subsidiary of Novartis, and, at the effective time of the merger, you will be entitled to receive $24.00 per share in cash, without interest and less any applicable withholding taxes, for each share of Endocyte common stock, par value $0.001 per share ("our common stock") that you own at the effective time of the merger (other than with respect to any shares of our common stock as to which you properly demand and perfect appraisal rights in accordance with Section 262 of the General Corporation Law of the State of Delaware).

        Our board of directors ("our board"), upon the unanimous affirmative recommendation of the special committee of our board, has unanimously determined that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and its stockholders, approved and declared advisable the merger agreement and the transactions contemplated by the merger agreement, including the merger, and recommended that the Endocyte stockholders adopt the merger agreement and directed that the merger agreement be submitted to the Endocyte stockholders for adoption at a special meeting. Accordingly, our board unanimously recommends that the stockholders of Endocyte, Inc. vote (1) "FOR" the proposal to adopt the merger agreement, (2) "FOR" the advisory (non-binding) proposal to approve certain compensation that may be paid or become payable to the named executive officers of Endocyte in connection with the merger, and (3) "FOR" the proposal to adjourn the special meeting, if necessary or appropriate, including to solicit additional proxies.

        Your vote is very important.    The merger cannot be completed unless holders of a majority of the outstanding shares of our common stock entitled to vote on the proposal cast their vote in favor of the proposal to adopt the merger agreement. A failure to vote your shares of our common stock on the proposal to adopt the merger agreement will have the same effect as a vote "AGAINST" the proposal to adopt the merger agreement.

        The attached proxy statement provides you with detailed information about the special meeting, the merger agreement and the merger. A copy of the merger agreement is attached as Annex A to the accompanying proxy statement. We encourage you to read the accompanying proxy statement and the


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merger agreement carefully and in their entirety. You may also obtain more information about Endocyte from documents we have filed with the Securities and Exchange Commission. See "Where You Can Find Additional Information."

        Whether or not you plan to attend the special meeting, please complete, date, sign and return, as promptly as possible, the enclosed proxy card in the accompanying reply envelope, or submit your proxy by telephone or the Internet. If you attend the special meeting and vote in person, your vote by ballot will revoke any proxy previously submitted.

        If you have any questions or need assistance in voting your shares, please contact our proxy solicitor, MacKenzie Partners, Inc., toll free, at (800) 322-2885.

        On behalf of our board, I thank you for your support and appreciate your consideration of this matter.

    Sincerely,

 

 

Michael A. Sherman
President, Chief Executive Officer, and Director

        Neither the Securities and Exchange Commission nor any state securities regulatory agency has approved or disapproved the merger, passed upon the merits or fairness of the merger, the merger agreement or the other transactions contemplated thereby or passed upon the adequacy or accuracy of the disclosure in the accompanying proxy statement. Any representation to the contrary is a criminal offense.

        The accompanying proxy statement is dated [                        ], 2018 and is first being mailed to stockholders on or about [                        ], 2018.


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ENDOCYTE, INC.
3000 Kent Avenue, Suite A1-100
West Lafayette, IN 47906

NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
TO BE HELD ON [                                    ], 2018

        NOTICE IS HEREBY GIVEN that a special meeting of the stockholders of Endocyte, Inc., a Delaware corporation (which we refer to as "Endocyte," the "Company," "we," "our" or "us"), will be held at [                        ], on [                        ], [    ], 2018 at [                        ] local time (the "special meeting"), to consider and vote upon the following proposals:

        Only stockholders of record as of the close of business on [                        ], 2018 are entitled to notice of and to vote at the special meeting and at any adjournment or postponement thereof.

        Our board, upon the unanimous affirmative recommendation of the special committee of our board, unanimously recommends that our stockholders vote (1) "FOR" the proposal to adopt the merger agreement, (2) "FOR" the advisory (non-binding) proposal to approve certain compensation that may be paid or become payable to the named executive officers of Endocyte in connection with the merger, and (3) "FOR" the proposal to adjourn the special meeting, if necessary or appropriate, including to solicit additional proxies.

        If the merger is consummated, holders of shares of our common stock who do not vote in favor of the adoption of the merger agreement, who properly demand an appraisal of their shares in accordance with Delaware law, who continuously hold such shares through the effective time of the merger, who otherwise comply with the applicable procedures and requirements of Delaware law (including with respect to certain aggregate ownership requirements) and who do not withdraw their demands, waive or otherwise lose their rights to appraisal will, subject to certain conditions and limitations under Delaware law, be entitled to seek appraisal of their shares in connection with the merger. The applicable Delaware law is reproduced in its entirety in Annex B to the accompanying proxy statement.

        Your vote is important, regardless of the number of shares of our common stock you own. Regardless of whether you plan to attend the special meeting in person, we request that you complete, sign, date and return the enclosed proxy or submit your proxy by telephone or the Internet prior to the special meeting to ensure that your shares will be represented at the special meeting. If you have Internet access, we encourage you to submit your proxy via the Internet. If you attend the special meeting, you may revoke your proxy and vote in person if you wish, even if you have previously returned your proxy card. Before voting your shares, we urge you to read the accompanying proxy statement carefully, including its annexes and the documents incorporated by reference in the document. Your prompt attention is greatly appreciated.

    By order of our board of directors,

 

 

Daniel L. Boeglin
Secretary

West Lafayette, Indiana
[                        ], 2018


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YOUR VOTE IS IMPORTANT

        If your shares are registered directly in your name:    If you are a stockholder of record, you may vote your shares through the Internet, by telephone or by mail as described below. Please help us save time and postage costs by voting through the Internet or by telephone. Each method is generally available 24 hours a day and will ensure that your vote is confirmed and posted immediately. To vote:

1.
BY INTERNET

a.
Go to the website at [                        ], 24 hours a day, seven days a week, until 11:59 p.m., Eastern Time on [                        ], 2018.

b.
Please have your proxy card available to verify your identity and create an electronic ballot.

c.
Follow the simple instructions provided.

2.
BY TELEPHONE

a.
On a touch-tone telephone, call toll-free [                        ], 24 hours a day, seven days a week, until 11:59 p.m., Eastern Time on [                        ], 2018.

b.
Please have your proxy card available to verify your identity.

c.
Follow the simple instructions provided.

3.
BY MAIL

a.
Mark, sign and date your proxy card.

b.
Return it in the postage-paid envelope that will be provided.

        If your shares are held in the name of a broker, bank or other nominee:    You should receive voting instructions from the organization holding your account and you must follow those instructions to vote your shares. As a beneficial owner, you have the right to direct your broker, bank or other nominee on how to vote the shares in your account. Your broker, bank or other nominee cannot vote on any of the proposals, including the proposal to adopt the merger agreement, without your instructions.

        If you fail to return your proxy card, grant your proxy electronically over the Internet or by telephone or vote by ballot in person at the special meeting, your shares will not be counted for purposes of determining whether a quorum is present at the special meeting. If you hold your shares through a broker, bank or other nominee, you must obtain from the record holder a valid legal proxy issued in your name to vote in person at the special meeting. A stockholder providing a proxy may revoke it at any time before it is exercised as described in the accompanying proxy statement.

        You should not return your stock certificate or send documents representing our common stock with the proxy card. If the merger is completed, the paying agent for the merger will send you a letter of transmittal and related materials and instructions for exchanging your shares of our common stock for the merger consideration.

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        We encourage you to read the accompanying proxy statement, including all documents incorporated by reference into the accompanying proxy statement, and its annexes carefully and in their entirety. If you have any questions concerning the merger, the special meeting or the accompanying proxy statement, would like additional copies of the accompanying proxy statement or need help voting your shares of common stock, please contact our proxy solicitor:

GRAPHIC

MacKenzie Partners, Inc.
1407 Broadway
New York, NY 10018
Stockholders May Call:
(800) 322-2885 (toll-free from the U.S. or Canada);
(212) 929-5500 (from other locations)

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TABLE OF CONTENTS

SUMMARY

  1

QUESTIONS AND ANSWERS ABOUT THE SPECIAL MEETING AND THE MERGER

  12

CAUTIONARY STATEMENT CONCERNING FORWARD-LOOKING STATEMENTS

  20

THE COMPANIES

  21

THE SPECIAL MEETING

  22

Date, Time and Place of the Special Meeting

  22

Purposes of the Special Meeting

  22

Record Date and Quorum

  23

Required Vote

  23

Voting by Endocyte's Directors and Executive Officers

  24

Voting; Proxies; Revocation

  24

Abstentions

  26

Special Committee's and Board of Directors' Recommendation

  26

Solicitation of Proxies

  27

Other Business

  27

Notice Regarding the Availability of Proxy Materials for the Special Meeting to be Held on [            ], 2018

  27

THE MERGER (PROPOSAL 1)

  28

Certain Effects of the Merger

  28

Effects on Endocyte if the Merger is Not Completed

  28

Background of the Merger

  29

Reasons for the Recommendation of the Special Committee and our Board

  40

Certain Endocyte Unaudited Prospective Financial Information

  45

Opinion of Centerview Partners LLC

  47

Opinion of Jefferies LLC

  54

Financing of the Merger

  60

Interests of Endocyte's Directors and Executive Officers in the Merger

  60

Indemnification of and Insurance for Directors and Executive Officers

  68

Material U.S. Federal Income Tax Consequences of the Merger

  69

Regulatory Approvals

  71

Exclusive Forum Bylaw

  72

Delisting and Deregistration of Endocyte Common Stock

  72

The Merger Agreement Proposal

  72

Vote Required and Board Recommendation

  73

THE MERGER AGREEMENT

  74

Explanatory Note Regarding the Merger Agreement

  74

Structure of the Merger; Certificate of Incorporation; Bylaws; Directors and Officers

  74

When the Merger Becomes Effective

  75

Effect of the Merger on the Common Stock

  75

Treatment of Endocyte Equity Awards; Employee Stock Purchase Plan

  76

Treatment of Outstanding Warrant

  76

Payment for Common Stock in the Merger. 

  77

Representations and Warranties; Material Adverse Effect

  77

Conduct of Business Pending the Merger

  80

No Solicitation; Alternative Proposals

  83

Change in Company Recommendation

  86

Efforts to Obtain Regulatory Approvals

  88

Endocyte Stockholders' Meeting

  91

Employee Matters

  91

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Indemnification and Insurance

  92

Coordination on Litigation

  92

Other Covenants and Agreements

  93

Conditions to Completion of the Merger

  93

Termination

  94

Fees and Expenses

  96

Termination Fees and Expense Reimbursement

  96

Amendment and Modification

  98

Extensions and Waivers

  98

Governing Law

  98

ADVISORY VOTE ON NAMED EXECUTIVE OFFICER MERGER-RELATED COMPENSATION (PROPOSAL 2)

  99

AUTHORITY TO ADJOURN THE SPECIAL MEETING (PROPOSAL 3)

  100

MARKET PRICE OF ENDOCYTE'S COMMON STOCK

  101

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

  102

APPRAISAL RIGHTS

  104

MULTIPLE STOCKHOLDERS SHARING ONE ADDRESS

  111

FUTURE STOCKHOLDER PROPOSALS

  111

WHERE YOU CAN FIND ADDITIONAL INFORMATION

  112

INFORMATION INCORPORATED BY REFERENCE

  112

MISCELLANEOUS

  113

ANNEX A—AGREEMENT AND PLAN OF MERGER

   

ANNEX B—SECTION 262 OF THE GENERAL CORPORATION LAW OF THE STATE OF DELAWARE

   

ANNEX C—OPINION OF CENTERVIEW PARTNERS LLC

   

ANNEX D—OPINION OF JEFFERIES LLC

   

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SUMMARY

        This summary highlights selected information from this proxy statement related to the merger of Edinburgh Merger Corporation with and into Endocyte, Inc., with Endocyte, Inc. surviving as a wholly owned subsidiary of Novartis AG, which transaction we refer to as the merger, and may not contain all of the information that is important to you. To understand the merger more fully and for a more complete description of the legal terms of the merger, you should read carefully this entire proxy statement, the annexes to this proxy statement, including the merger agreement, and the documents we incorporate by reference in this proxy statement. You may obtain the documents and information incorporated by reference in this proxy statement without charge by following the instructions under "Information Incorporated by Reference" beginning on page 112. The merger agreement is attached as Annex A to this proxy statement.

The Companies (page 21)

Endocyte

        Endocyte, Inc., referred to as "Endocyte," the "Company," "we," "our" or "us," is a Delaware corporation. We are a biopharmaceutical company and leader in developing targeted therapies for the treatment of cancer. We use drug conjugation technology to create novel therapeutics and companion imaging agents for personalized targeted therapies. Our agents actively target receptors that are over-expressed on diseased cells relative to healthy cells, such as prostate specific membrane antigen ("PSMA") in prostate cancer. This targeted approach is designed to safely enable the delivery of highly potent drug payloads. The companion imaging agents are designed to identify patients whose disease over-expresses the target of the therapy and who are therefore more likely to benefit from treatment. Our principal executive offices are located at 3000 Kent Avenue, Suite A1-100, West Lafayette, Indiana 47906, and our telephone number is (765) 463-7175. See "Where You Can Find Additional Information" on page 112 and "The Companies—Endocyte, Inc." on page 21.

Novartis

        Novartis AG, referred to as "Novartis" or "Buyer," was incorporated on February 29, 1996 under the laws of Switzerland as a stock corporation (Aktiengesellschaft) with an indefinite duration. On December 20, 1996, the predecessor companies of Buyer, Ciba-Geigy and Sandoz, merged into a new entity, creating the Novartis Group (the "Novartis Group"). Buyer is domiciled in and governed by the laws of Switzerland. Its registered office is located at Lichtstrasse 35, CH-4056 Basel, Switzerland, and its telephone number is +41-61-324-1111. The following description of Buyer and its business is qualified in its entirety by reference to Buyer's Annual Report on Form 20-F for the fiscal year ended December 31, 2017 and its Registration Statement on Form F-4 filed with the Securities and Exchange Commission (the "SEC") on December 23, 2010, as amended.

        The Novartis Group is a multinational group of companies specializing in the research, development, manufacturing and marketing of a broad range of healthcare products led by innovative pharmaceuticals. Buyer is the Novartis Group's Swiss holding company and owns, directly or indirectly, all of the Novartis Group's significant operating companies. See "The Companies—Novartis AG."

Merger Sub

        Edinburgh Merger Corporation, referred to as "Merger Sub," is a Delaware corporation and a wholly owned subsidiary of Novartis that was formed solely for the purpose of entering into the merger agreement and consummating the transactions contemplated by the merger agreement. Upon completion of the merger, Merger Sub will cease to exist and Endocyte will continue as the surviving corporation. Merger Sub's principal executive offices are located at 230 Park Avenue, 21st Floor, New York, New York 10169, and its telephone number is (212) 830-2414. See "The Companies—Edinburgh Merger Corporation."

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The Merger (Proposal 1) (page 28)

        You will be asked to consider and vote upon the proposal to adopt the Agreement and Plan of Merger, dated as of October 17, 2018, by and among Endocyte, Novartis and Merger Sub (as it may be amended from time to time, the "merger agreement"). A copy of the merger agreement is attached as Annex A to this proxy statement. The merger agreement provides, among other things, that at the effective time of the merger (the "effective time"), Merger Sub will be merged with and into Endocyte, and each issued and outstanding share of common stock, par value $0.001 per share, of Endocyte ("our common stock" or "Endocyte common stock"), other than shares of our common stock owned by Endocyte, Novartis or Merger Sub immediately prior to the effective time (the "excluded shares") and any shares of our common stock as to which the holder is entitled to demand and has properly demanded and perfected appraisal rights under, and has complied in all respects with, Section 262 of the General Corporation Law of the State of Delaware ("DGCL") (and has not validly withdrawn, waived or otherwise lost such rights) (the "appraisal shares"), will be converted automatically into the right to receive $24.00 in cash, without interest and less any applicable withholding taxes (the "merger consideration").

The Special Meeting (page 22)

        Date, Time and Place of the Special Meeting.    The special meeting will be held at [        ], local time, on [            ], 2018 at [                        ]. To attend the meeting, you will need to present valid government-issued photo identification, such as a driver's license or passport. If your shares are held in the name of a broker, bank or other nominee, you will also need to present a recent brokerage statement or letter from such entity reflecting your stock ownership as of the record date. If you do not provide photo identification or comply with the other procedures outlined in this proxy statement, you will not be admitted to the special meeting. For security reasons, you and your bags may be subject to search prior to your admittance to the meeting.

        Purposes of the Special Meeting.    At the special meeting, you will be asked (1) to consider and vote on the proposal to adopt the merger agreement, pursuant to which Merger Sub will be merged with and into Endocyte; (2) to consider and vote on the proposal to approve, on an advisory (non-binding) basis, certain compensation that may be paid or become payable to Endocyte's named executive officers in connection with the merger; and (3) to consider and vote on the proposal to approve the adjournment of the special meeting, if necessary or appropriate, including to solicit additional proxies if there are insufficient votes at the time of the special meeting to approve the proposal to adopt the merger agreement.

        Who Can Vote at the Meeting.    You can vote at the special meeting, in person or by proxy, all of the shares of our common stock you own of record as of [                        ], 2018, which is the record date for the special meeting. If you own shares that are registered in someone else's name, for example, a broker, you need to direct that person to vote those shares or obtain a legal proxy from them and vote the shares yourself at the meeting. As of [                        ], 2018, there were [                ] shares of our common stock outstanding held by approximately [            ] holders of record. You are entitled to one vote on each of the proposals for each share of our common stock that you held on the record date.

        What Vote is Required for Adoption of the Merger Agreement.    Approval of the proposal to adopt the merger agreement requires the affirmative vote of the holders of a majority of the outstanding shares of our common stock entitled to vote thereon. A failure to vote your shares of our common stock or an abstention from voting will have the same effect as a vote "AGAINST" the proposal to adopt the merger agreement. If your shares are held in "street name" by your broker, bank or other nominee and you do not instruct the nominee how to vote your shares, such failure to instruct your nominee will have the same effect as a vote "AGAINST" the proposal to adopt the merger agreement.

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        Quorum.    A quorum will be present if holders of a majority of the shares of our common stock outstanding at the close of business on the record date are present in person or represented by proxy at the special meeting. If a quorum is not present at the special meeting, the special meeting may be adjourned or postponed from time to time until a quorum is obtained.

        Procedure for Voting.    You can vote shares you hold of record by attending the special meeting and voting in person or by mailing the enclosed proxy card or voting by telephone or through the Internet. If your shares are held in "street name" by your broker, you should instruct your broker on how to vote your shares using the instructions provided by your broker. If you do not instruct your broker to vote your shares, your shares will not be voted, which will have the same effect as a vote against adoption of the merger agreement, unless you attend the special meeting and present a valid legal proxy executed in your favor from your broker, bank or other nominee.

        How to Revoke Your Proxy.    You may revoke your proxy and change your vote at any time before your proxy is voted at the special meeting. If you are a stockholder of record, you may revoke your proxy by (i) delivering a later-dated proxy in writing, over the telephone or via the Internet, and submitting it so that it is received prior to the cut-off time in accordance with the instructions included in the proxy card; (ii) delivering a written notice of revocation to our Corporate Secretary, Endocyte, Inc., 8910 Purdue Road, Suite 250, Indianapolis, Indiana 46268 that is received prior to the special meeting, stating that you revoke your proxy; or (iii) attending the special meeting and voting in person. If you hold your shares in "street name" and you have instructed a broker, bank or other nominee to vote your shares, you should instead follow the instructions received from your broker, bank or other nominee to revoke your prior voting instructions.

Shares Held by Directors and Executive Officers (page 102)

        At the close of business on the record date, directors and executive officers of Endocyte were entitled to vote approximately [            ] shares of our common stock, which in the aggregate represented approximately [        ]% of the shares of our common stock issued and outstanding on such date. See "Security Ownership of Certain Beneficial Owners and Management."

        We currently expect that our directors and executive officers will vote their shares in favor of the proposal to adopt the merger agreement and the other proposals to be considered at the special meeting, although they have no obligation to do so.

Background of the Merger (page 29)

        A description of the process we undertook that led to the proposed merger, including our discussions with Novartis, is included in this proxy statement under "The Merger (Proposal 1)—Background of the Merger".

Recommendation of the Endocyte Special Committee and Board of Directors (page 26); Reasons for the Recommendation of the Special Committee and our Board (page 40)

        Our board of directors ("our board" or the "board") and the special committee of our board (the "special committee") has unanimously approved the merger agreement, the merger and the other transactions contemplated by the merger agreement. Our board (based on the unanimous affirmative recommendation of the special committee of our board) unanimously recommends that Endocyte stockholders vote "FOR" the proposal to adopt the merger agreement at the special meeting. In addition, our board unanimously recommends that Endocyte stockholders vote "FOR" the advisory (non-binding) proposal to approve the merger-related compensation and "FOR" the proposal to adjourn the special meeting (each as described above under "—The Special Meeting").

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        For a description of the reasons considered by our board in deciding to recommend adoption of the merger agreement, see the section entitled "The Merger (Proposal 1)—Reasons for the Recommendation of the Special Committee and our Board."

Opinion of Centerview Partners LLC (page 47)

        Endocyte retained Centerview Partners LLC ("Centerview") as a financial advisor to Endocyte, the special committee and our board in connection with the transactions contemplated by the merger agreement. In connection with the merger, Centerview delivered to the special committee and our board its written opinion dated October 17, 2018 that, as of such date and based upon and subject to the various assumptions made, procedures followed, matters considered, and qualifications and limitations upon the review undertaken by Centerview in preparing its opinion, the $24.00 per share merger consideration proposed to be paid to the holders of shares (other than (i) shares that are owned by Endocyte, Novartis, Merger Sub or any direct or indirect wholly owned subsidiary of Novartis and (ii) shares that are outstanding immediately prior to the effective time of the merger and that are held by any person who is entitled to demand and properly demands appraisal of such shares pursuant to, and who complies in all respects with, Section 262 of the DGCL) pursuant to the merger agreement was fair, from a financial point of view, to such holders. The full text of Centerview's written opinion, which describes the various assumptions made, procedures followed, matters considered, and qualifications and limitations upon the review undertaken by Centerview in preparing its opinion, is attached as Annex C to this proxy statement and is incorporated herein by reference. Centerview's financial advisory services and opinion were provided for the information and assistance of the special committee and our board (in their capacity as directors and not in any other capacity) in connection with and for purposes of their consideration of the transactions contemplated by the merger agreement, and Centerview's opinion addressed only the fairness, from a financial point of view, as of the date thereof, to the holders of shares (other than the shares referred to in clauses (i) and (ii) above, together with any shares held by any affiliate of Endocyte or Novartis) of the $24.00 per share merger consideration to be paid to such holders pursuant to the merger agreement. Centerview's opinion did not address any other term or aspect of the merger agreement or the transactions contemplated thereby and does not constitute a recommendation to any stockholder of Endocyte or any other person as to how such stockholder or other person should vote with respect to the merger or otherwise act with respect to the transactions contemplated by the merger agreement or any other matter. The summary of Centerview's opinion set forth below under "The Merger (Proposal 1)—Opinion of Centerview Partners LLC" is qualified in its entirety by reference to the full text of Centerview's opinion.

Opinion of Jefferies LLC (page 54)

        Endocyte has engaged Jefferies LLC ("Jefferies") as a financial advisor to Endocyte in connection with the merger. In connection with the merger, Jefferies delivered a written opinion, dated October 17, 2018, to the board and the special committee as to the fairness, from a financial point of view and as of such date, of the $24.00 per share merger consideration to be received by holders of Endocyte common stock (other than, to the extent applicable, Novartis, Merger Sub and their respective affiliates) pursuant to the merger agreement. The full text of Jefferies' opinion, which describes the various assumptions made, procedures followed, matters considered and limitations and qualifications on the review undertaken by Jefferies, is attached as Annex D to this proxy statement and is incorporated herein by reference. Jefferies' opinion was provided for the use and benefit of the board and the special committee (in their respective capacities as such) in their evaluation of the per share merger consideration from a financial point of view and did not address any other aspect of the merger or any other matter. The opinion did not address the relative merits of the merger as compared to any alternative transaction or opportunity that might be available to Endocyte, nor did it address the underlying business decision by Endocyte to engage in the merger. Jefferies' opinion does

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not constitute a recommendation as to how any securityholder should vote or act with respect to the merger or any other matter. The summary of Jefferies' opinion set forth below under "The Merger (Proposal 1)—Opinion of Jefferies LLC" is qualified in its entirety by reference to the full text of Jefferies' opinion.

Certain Effects of the Merger (page 28)

        Pursuant to the terms of the merger agreement, Merger Sub will be merged with and into Endocyte, with Endocyte surviving the merger. Throughout this proxy statement, we use the term "surviving corporation" to refer to Endocyte as the surviving corporation following the merger. The time at which the merger will become effective, which we refer to as the "effective time," will occur at the time the certificate of merger is duly filed with the Secretary of State of the State of Delaware or at such other time as Novartis and Endocyte agree and specify in the certificate of merger.

        If the merger is consummated, as soon as reasonably practicable following the effective time, our common stock will be delisted from the Nasdaq Global Market and deregistered under the U.S. Securities Exchange Act of 1934, as amended (the "Exchange Act"), and we will no longer be a publicly traded company. If the merger is consummated, you will not own any shares of the capital stock of the surviving corporation. At the effective time, your shares of Endocyte common stock will no longer be outstanding and will automatically be canceled and retired and will cease to exist, and you will cease to have any rights with respect to such shares, except the right to receive the merger consideration.

Effects on Endocyte if the Merger is Not Completed (page 28)

        If the merger agreement is not adopted by our stockholders or if the merger is not consummated for any other reason, our stockholders will not receive any payment for their shares of common stock. Instead, we will remain a public company, our common stock will continue to be listed and traded on the Nasdaq Global Market and registered under the Exchange Act and we will continue to file periodic reports with the SEC. Under specified circumstances, we may be required to pay Novartis a termination fee upon or following the termination of the merger agreement, or Novartis may be required to pay us a reverse termination fee, as described under "The Merger Agreement—Termination Fees and Expense Reimbursement" beginning on page 96.

Timing of the Merger (page 75)

        The merger agreement provides that the closing of the merger will be no later than the third business day after the satisfaction or, to the extent permitted by law, waiver by the party entitled thereto, of the conditions set forth in the merger agreement to be so satisfied or waived, or at such later date as the parties agree in writing. As of the date of this proxy statement, the parties expect to complete the merger in the first half of 2019. However, completion of the merger is subject to the satisfaction or waiver of the conditions to the completion of the merger, and factors outside the control of Endocyte or Novartis may delay the completion of the merger or prevent it from being completed at all. There can be no assurances as to whether or when the merger will be completed, or that it will be completed as currently proposed, or at any particular time.

Treatment of Endocyte Equity Awards (page 76); Employee Stock Purchase Plan (page 76)

        Stock Options.    At the effective time, each Endocyte option to purchase shares of our common stock (a "stock option") that is outstanding and unexercised immediately prior to the effective time, whether vested or unvested, will (i) if the exercise price of such stock option is less than the merger consideration, be canceled, with the holder of such stock option becoming entitled to receive an amount in cash, without interest, equal to (a) the excess of the merger consideration over the exercise

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price of the stock option, multiplied by (b) the number of shares of our common stock subject to such stock option as of immediately prior to the effective time (subject to any applicable withholding taxes); or (ii) if the exercise price of such stock option is equal to or greater than the merger consideration, be canceled without any consideration being payable.

        Restricted Stock Units.    At the effective time, each Endocyte restricted stock unit ("RSU") that is outstanding and not settled immediately prior to the effective time, whether vested or unvested, will be canceled and converted into the right to receive an amount in cash, without interest, equal to the merger consideration multiplied by the number of shares of our common stock subject to such RSU as of immediately prior to the effective time (subject to any applicable withholding taxes).

        2010 Employee Stock Purchase Plan ("ESPP").    If the effective time occurs on or before the end of the ESPP offering period in effect as of the date of the merger agreement (the "current offering period"), the surviving corporation will pay to each participant in the current offering period an amount in cash equal to (i) the merger consideration multiplied by (ii) the result obtained by dividing (A) the amount of the payroll deductions credited to such participant's account pursuant to the ESPP as of the effective time by (B) the purchase price (as defined in the ESPP, with the last day of the applicable purchase period being deemed to be the date on which the effective time occurs), net of any applicable taxes withheld. If the effective time occurs after the last day of the current offering period, we will issue shares of our common stock to participants in the ESPP pursuant to the terms of the ESPP for the current offering period and such shares will be treated like all other outstanding shares of common stock in the merger.

Treatment of Outstanding Warrant (page 76)

        There is an outstanding warrant to purchase 442,000 shares of our common stock at an exercise price of $1.39, held by Cambridge Isotope Laboratories, Inc. Pursuant to the terms of the merger agreement and the warrant, the warrant will be automatically exercised immediately prior to the effective time, and the holder of the warrant will participate in the merger as a holder of our common stock on the same terms as other holders of our common stock, but the holder's aggregate consideration received in the merger will be reduced by the aggregate exercise price then in effect for the shares purchasable under the warrant.

No Solicitation; Alternative Proposals (page 83)

        The merger agreement restricts our ability to solicit, initiate or engage in discussions or negotiations with a third party (including by furnishing non-public information) regarding competing transactions and our ability to change or withdraw the company recommendation. We refer in this proxy statement to the following recommendation as the "company recommendation": our board and its special committee (i) determining that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and its stockholders, (ii) approving and declaring advisable the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement, and (iii) recommending (A) in the case of the special committee, that our board approve the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement and (B) in the case of our board, that the holders of shares of our common stock adopt the merger agreement and directing that the merger agreement be submitted to our stockholders at the special stockholders meeting.

        Notwithstanding these restrictions, under circumstances specified in the merger agreement, our board may respond to unsolicited bona fide written competing proposals and may terminate the merger agreement and enter into an agreement with respect to a superior proposal (as defined in the merger

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agreement) or withdraw the company recommendation in favor of the merger agreement, subject to the payment by Endocyte of a $73.5 million termination fee to Novartis. See "The Merger Agreement—No Solicitation; Alternative Proposals."

Change in Company Recommendation (page 86)

        Our board, upon the unanimous affirmative recommendation of the special committee of our board, unanimously recommends that our stockholders vote "FOR" the proposal to adopt the merger agreement. Nevertheless, under circumstances specified in the merger agreement and prior to the adoption of the merger agreement by Endocyte stockholders, our board may make a change of recommendation or terminate the merger agreement to enter into a definitive agreement with respect to a superior proposal (as defined in the section entitled "The Merger Agreement—No Solicitation; Alternative Proposals") if we receive an unsolicited bona fide written takeover proposal that our board or a committee thereof, after consultation with outside legal and financial advisors, concludes constitutes a superior proposal (taking into account any offers made by Novartis to adjust the terms of the merger agreement) or if there has been an intervening event unrelated to a takeover proposal and, in any event, our board or a committee thereof determines, after consultation with outside legal advisors, that failure to take such action would be inconsistent with our directors' fiduciary duties under applicable law.

Interests of Endocyte's Directors and Executive Officers in the Merger (page 60)

        When considering the recommendation by our board in favor of the merger agreement and the merger, you should be aware that our directors and executive officers have interests in the merger that are different from, or in addition to, yours, including the following:

    payments in connection with stock options, RSUs and the ESPP at the closing of the merger, as described in the section entitled "The Merger Agreement—Treatment of Endocyte Equity Awards; Employee Stock Purchase Plan";

    the entitlement of certain of our executive officers to receive payments and benefits under their respective change in control and severance agreements; and

    continued indemnification and directors' and officers' liability insurance to be provided by the surviving corporation.

        If the proposal to adopt the merger agreement is approved by our stockholders and the merger closes, any shares of our common stock held by our directors and executive officers will be treated in the same manner as outstanding shares of our common stock held by all of our other stockholders entitled to receive the per-share merger consideration.

        See "The Merger (Proposal 1)—Interests of Endocyte's Directors and Executive Officers in the Merger."

        The members of our board were aware of these interests of our directors and executive officers and considered them, among other matters, when approving the merger agreement and the merger and determining to recommend that our stockholders vote "FOR" the adoption of the merger agreement.

Material U.S. Federal Income Tax Consequences of the Merger (page 69)

        If you are a U.S. holder (as defined under "The Merger (Proposal 1)—Material U.S. Federal Income Tax Consequences of the Merger"), the receipt of cash in exchange for shares of our common stock pursuant to the merger will generally be a taxable transaction for U.S. federal income tax purposes, and may also be a taxable transaction under applicable state, local or foreign income or other tax laws. You should consult your own tax advisor regarding the particular tax consequences to you of the exchange of shares of our common stock for cash pursuant to the merger in light of your particular

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circumstances (including the application and effect of any state, local or foreign income and other tax laws).

Regulatory Approvals (page 71)

        HSR Waiting Period.    Under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (the "HSR Act") and the rules promulgated thereunder, the merger may not be completed until notifications have been given and information furnished to the Antitrust Division of the United States Department of Justice (the "Antitrust Division") and the United States Federal Trade Commission (the "FTC") and all statutory waiting period requirements have been satisfied.

        Committee on Foreign Investment in the United States Review.    The merger will be reviewed by the Committee on Foreign Investment in the United States ("CFIUS") pursuant to Section 721 of the Defense Production Act of 1950, as amended ("Section 721"). Under Section 721, the President of the United States, on the recommendation of CFIUS, may prohibit or suspend certain transactions, including the merger, of persons engaged in interstate commerce in the United States by foreign persons. The merger may not be completed until all required declarations have been submitted to CFIUS, all information requested has been furnished to CFIUS and all applicable waiting period requirements have been satisfied.

        Other Required Regulatory Approvals.    Completion of the merger is also subject to the receipt of certain antitrust or competition approvals of other jurisdictions if such approvals are required to complete the merger. Novartis and Endocyte are not presently aware of any such applicable approvals that are required under antitrust or other competition laws of other jurisdictions that would require Novartis and Endocyte to make any filings thereunder in order to complete the merger.

Financing of the Merger (page 60)

        The merger is not conditioned upon receipt of financing by Novartis. Novartis plans to finance the transaction through cash on hand.

Conditions to Completion of the Merger (page 93)

        The conditions to each party's obligations to complete the merger include the following:

    the adoption of the merger agreement by our stockholders;

    the absence of any legal restraints restraining, enjoining, preventing, prohibiting or otherwise making illegal the consummation of the merger or the other transactions contemplated by the merger agreement;

    the expiration or termination of any applicable waiting period under the HSR Act and under Section 721, and all other required regulatory approvals will have been obtained;

    the accuracy of the other party's representations and warranties in the merger agreement, subject to certain qualifications; and

    the other party's performance in all material respects of its obligations under the merger agreement.

        In addition, the conditions to Novartis' and Merger Sub's obligations to complete the merger also include the following:

    the absence of a material adverse effect with respect to Endocyte (as defined in the merger agreement);

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    the absence of any pending proceeding brought by any governmental entity seeking to (i) restrain, enjoin, prevent, prohibit or otherwise make illegal the consummation of the merger or the other transactions contemplated by the merger agreement, or (ii) impose a burdensome condition (as defined in the merger agreement) on Novartis; and

    the absence of any legal restraint imposing a burdensome condition.

Termination (page 94)

        The merger agreement may be terminated (subject, in each case, to certain limitations):

    by mutual written consent of Novartis, Merger Sub and Endocyte;

    by either Novartis or Endocyte if:

    the merger has not been consummated on or before July 17, 2019, subject to certain extensions permitted by the merger agreement to April 17, 2020;

    any legal restraint permanently restraining, enjoining, preventing, prohibiting or otherwise making illegal the consummation of the merger or the other transactions contemplated by the merger agreement is in effect and has become final and non-appealable; or

    our stockholders do not approve the proposal to adopt the merger agreement at the special meeting at which a vote on that matter is taken;

    by Novartis if:

    Endocyte breaches any of its representations or warranties or fails to perform any of its covenants or obligations contained in the merger agreement, which breach or failure to perform would give rise to the failure of the related conditions to Novartis' obligation to close the merger to be satisfied and cannot be cured or, if capable of being cured, has not been cured prior to the time specified in the merger agreement;

    prior to receipt of the requisite vote of Endocyte stockholders adopting the merger agreement, (i) an adverse recommendation change (as defined in the merger agreement) has occurred, (ii) Endocyte enters into a definitive written agreement providing for the consummation of a superior proposal, (iii) our board or any committee thereof has failed to reaffirm the company recommendation within 10 business days after the receipt of a written request to do so from Novartis following a takeover proposal that has been publicly announced or that has become publicly known (subject to certain limitations), or (iv) Endocyte has committed a willful and material breach of its obligations under the provisions of the merger agreement relating to no solicitation of other offers and changes in the company recommendation, which breach, if capable of being cured, has not been cured within five days after Novartis has given written notice to Endocyte of such breach; and

    any legal restraint imposing a burdensome condition is in effect and has become final and non-appealable; or

    by Endocyte if:

    Novartis or Merger Sub breaches any of its representations or warranties or fails to perform any of its covenants or obligations contained in the merger agreement, which breach or failure to perform would give rise to the failure of the related conditions to Endocyte's obligation to close the merger to be satisfied and cannot be cured or, if capable of being cured, has not been cured prior to the time specified in the merger agreement; and

    prior to receipt of the requisite vote of Endocyte stockholders adopting the merger agreement, in order to enter into, concurrently with the termination of the merger

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        agreement, a definitive written agreement providing for the consummation of a superior proposal in accordance with the applicable terms of the merger agreement, so long as Endocyte has complied in all material respects with the provisions of the merger agreement relating to no solicitation of other offers and changes in the company recommendation, and Endocyte has paid, or simultaneously with the termination of the merger agreement pays, to Novartis the $73.5 million termination fee.

Termination Fees and Expense Reimbursement (page 96)

        Following termination of the merger agreement under specified circumstances generally relating to a competing transaction, Endocyte may be required to pay Novartis a termination fee of $73.5 million. The merger agreement also provides that Novartis will be required to pay Endocyte a reverse termination fee of $150.0 million under certain specified circumstances generally relating to the termination of the merger agreement if certain regulatory approvals required to consummate the merger have not been obtained or certain types of legal restraints on the merger are imposed.

        In the event that the merger agreement is terminated as a result of the failure to obtain the requisite vote of Endocyte stockholders adopting the merger agreement, Endocyte will pay to Novartis an amount equal to Novartis' reasonable out-of-pocket fees and expenses incurred in connection with the transactions, up to a maximum amount of $5.0 million.

Employee Matters (page 91)

        The merger agreement provides for certain treatment with respect to those employees of Endocyte who continue to be employed by the surviving corporation or one of its subsidiaries after the effective time, whom we refer to as the "continuing employees," including the following:

    from the effective time through the first anniversary of the effective time, continuing employees will receive: (i) base salaries or wage rates no less than such continuing employee's base salary or wage rate as of immediately prior to the effective time, (ii) severance pay and benefits no less favorable than severance pay and benefits set forth in the disclosure letter, and (iii) other employee benefits that are substantially comparable in the aggregate to those provided to such continuing employees immediately prior to the effective time; provided that neither Novartis nor the surviving corporation nor any of Novartis' subsidiaries will have any obligation to issue, or adopt any plans or arrangements providing for the issuance of, equity interests pursuant to any such plans or arrangements; provided further that no plans or arrangements of Endocyte providing for such issuance will be taken into account in determining whether employee benefits are substantially comparable in the aggregate; and

    Novartis will cause the surviving corporation to recognize the service of each continuing employee as if such service had been performed with Novartis (i) for purposes of benefits under Novartis' vacation program, (ii) for purposes of eligibility to participate in any health or welfare plan maintained by Novartis (other than any post-employment health or post-employment welfare plan) and Novartis' 401(k) plan and (iii) unless covered under another arrangement with or of Endocyte, for benefit accrual purposes under Novartis' severance plan (in the case of each of clauses (i), (ii) and (iii), solely to the extent that Novartis makes such plan or program available to employees of the surviving corporation and not in any case where credit would result in duplication of benefits), but not for purposes of any other employee benefit plan of Novartis.

Market Prices and Dividend Data (page 101)

        Our common stock is listed on the Nasdaq Global Market, under the symbol "ECYT." The closing sale price of our common stock on October 17, 2018, which was the last trading day before the merger

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was publicly announced, was $15.56 per share. On [                        ], 2018, the most recent practicable date before the filing of this proxy statement, the closing price of our common stock was $[        ] per share. You are encouraged to obtain current market quotations for our common stock in connection with voting your shares of our common stock. See "Market Price of Endocyte's Common Stock."

        Under the terms of the merger agreement, during the period from the date of the merger agreement until the effective time, we may not declare or pay any cash dividends to our stockholders without Novartis' written consent. We have never declared or paid any dividends on our capital stock. Under our current dividend policy, we intend to retain all future earnings for the operation and expansion of our business and, therefore, we do not anticipate declaring or paying cash dividends for the foreseeable future.

Appraisal Rights (page 104)

        Shares of common stock held by stockholders who have properly exercised their appraisal rights under Section 262 of the DGCL (and have not validly withdrawn such exercise, waived or otherwise lost such rights) will not be converted into the right to receive the merger consideration, but will instead be converted into the right to receive payment in cash for the fair value of their shares of common stock as determined in accordance with Section 262 of the DGCL. The fair value of shares of common stock as determined in accordance with Section 262 of the DGCL may be more or less than (or the same as) the merger consideration. Stockholders who wish to exercise their appraisal rights must comply strictly with all applicable procedures and requirements of Section 262 of the DGCL, which is summarized in this proxy statement and attached as Annex B to this proxy statement. Failure to comply strictly with the applicable requirements specified under Section 262 of the DGCL may result in the loss of appraisal rights. Because of the complexity of Section 262 of the DGCL relating to appraisal rights, if you are considering exercising your appraisal rights, we encourage you to seek the advice of your own legal counsel. See "Appraisal Rights."

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QUESTIONS AND ANSWERS ABOUT THE SPECIAL MEETING AND THE MERGER

        The following questions and answers address briefly some questions you may have regarding the special meeting and the proposals to be voted on at the special meeting. These questions and answers may not address all of the questions that may be important to you as a stockholder of Endocyte. Please refer to the more detailed information contained elsewhere in this proxy statement, the annexes to this proxy statement and the documents referred to or incorporated by reference in this proxy statement, which we urge you to read carefully and in their entirety. You may obtain the information incorporated by reference into this proxy statement without charge by following the instructions under the section entitled "Information Incorporated by Reference."

Q:
Why am I receiving this proxy statement?

A:
On October 17, 2018, Endocyte entered into a definitive agreement providing for the merger of Merger Sub, a wholly owned subsidiary of Novartis, with and into Endocyte, with Endocyte surviving the merger as a wholly owned subsidiary of Novartis. You are receiving this proxy statement in connection with the solicitation of proxies by our board in favor of the proposal to adopt the merger agreement and two related proposals.

Q:
What is a proxy?

A:
A proxy is your legal designation of another person, referred to as a "proxy," to vote your shares of our common stock. The written document describing the matters to be considered and voted on at the special meeting is called a "proxy statement." The document used to designate a proxy to vote your shares of our common stock is called a "proxy card." Our board has designated Michael A. Sherman and Michael T. Andriole, and each of them with full power of substitution, as proxies for the special meeting.

Q:
When and where is the special meeting?

A:
The special meeting will be held at [                        ], on [                        ], 2018, at [            ] local time (including any adjournment or postponement thereof, the "special meeting").

Q:
Who is entitled to vote at the special meeting?

A:
Only holders of record of our common stock as of the close of business on [                        ], 2018, the record date for the special meeting, are entitled to receive these proxy materials and to vote their shares at the special meeting. As of the close of business on the record date, there were [                        ] shares of our common stock outstanding and entitled to vote at the special meeting, held by approximately [            ] holders of record. Each share of our common stock issued and outstanding as of the record date will be entitled to one vote on each matter submitted to a vote at the special meeting.

Q:
What is the difference between holding shares as a stockholder of record and as a beneficial owner?

A:
If your shares are registered directly in your name with our transfer agent, Computershare Inc., you are considered, with respect to those shares, to be the "stockholder of record." In this case, we have sent this proxy statement and your proxy card to you directly.

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Q:
What matters will be voted on at the special meeting?

A:
You will be asked to consider and vote on the following proposals:

to adopt the merger agreement;

to approve, on an advisory (non-binding) basis, certain compensation that may be paid or become payable to the named executive officers of Endocyte in connection with the merger; and

to approve the adjournment of the special meeting, if necessary or appropriate, including to solicit additional proxies if there are insufficient votes at the time of the special meeting to approve the proposal to adopt the merger agreement.

Q:
What is the proposed merger and what effects will it have on Endocyte?

A:
The proposed merger is the acquisition of Endocyte by Novartis pursuant to the merger agreement. If the proposal to adopt the merger agreement is approved by the holders of our common stock and the other closing conditions under the merger agreement have been satisfied or waived, Merger Sub will merge with and into Endocyte, with Endocyte continuing as the surviving corporation. As a result of the merger, Endocyte will become a wholly owned subsidiary of Novartis. We will cooperate with Novartis to delist our common stock from the Nasdaq Global Market and deregister under the Exchange Act as soon as reasonably practicable following the effective time of the merger, and at such time, we will no longer be a publicly traded company and will no longer file periodic reports with the SEC. If the merger is consummated, you will not own any shares of the capital stock of the surviving corporation.

Q:
What happens if the merger is not completed?

A:
If the merger agreement is not approved by our stockholders or if the merger is not consummated for any other reason, our stockholders will not receive any payment for their shares of common stock. Instead, we will remain a public company, our common stock will continue to be listed and traded on the Nasdaq Global Market and registered under the Exchange Act and we will continue to file periodic reports with the SEC.
Q:
What will I receive if the merger is completed?

A:
Upon completion of the merger, you will be entitled to receive the per-share merger consideration of $24.00 in cash, without interest and less any applicable withholding taxes, for each share of common stock that you own, unless you have properly exercised, perfected and not validly withdrawn, waived or otherwise lost your appraisal rights under the DGCL with respect to such shares, and certain other conditions under the DGCL are satisfied (as described in more detail in the section of this proxy statement entitled "Appraisal Rights"). In either case, you will not own shares in the surviving corporation.

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Q:
What will the holders of Endocyte stock options and RSUs receive in the merger?

A:
Stock Options.    At the effective time, each stock option that is outstanding and unexercised immediately prior to the effective time, whether vested or unvested, will (i) if the exercise price of such stock option is less than the merger consideration, be canceled, with the holder of such stock option becoming entitled to receive an amount in cash, without interest, equal to (a) the excess of the merger consideration over the exercise price of the stock option, multiplied by (b) the number of shares of our common stock subject to such stock option as of immediately prior to the effective time (subject to any applicable withholding taxes); or (ii) if the exercise price of such stock option is equal to or greater than the merger consideration, be canceled without any consideration being payable.
Q:
What will happen to the Endocyte 2010 Employee Stock Purchase Plan in the merger?

A:
If the effective time occurs on or before the end of the ESPP current offering period, then reasonably promptly following the effective time, the surviving corporation will pay to each participant in the current offering period an amount in cash equal to (i) the merger consideration multiplied by (ii) the result obtained by dividing (A) the amount of the payroll deductions credited to such participant's account pursuant to the ESPP as of the effective time by (B) the purchase price (as defined in the ESPP, with the last day of the applicable purchase period being deemed to be the date on which the effective time occurs), net of any applicable taxes withheld. If the effective time occurs after the last day of the current offering period, we will issue shares of our common stock to participants in the ESPP pursuant to the terms of the ESPP for the current offering period and such shares will be treated like all other outstanding shares of common stock in the merger. In addition, we have agreed that, during the term of the merger agreement, we will not permit any further offering periods to commence under the ESPP, and we will not allow participants in the ESPP to increase their payroll deductions from those in effect on the date of the merger agreement or allow anyone who is not a participant in the ESPP as of the date of the merger agreement to become a participant. We will terminate the ESPP effective as of the effective time, and if the effective time has not occurred by the end of the current offering period, then we will suspend the ESPP until the effective time.

Q:
When do you expect the merger to be completed?

A:
We are working toward completing the merger as soon as possible, and currently expect to consummate the merger during the first half of 2019. However, the exact timing of completion of the merger cannot be predicted because the merger is subject to conditions, including approval of the adoption of the merger agreement by our stockholders and the receipt of certain regulatory approvals, that are out of our control. See "The Merger Agreement—General" and "The Merger Agreement—Conditions to Completion of the Merger."

Q:
Am I entitled to appraisal or dissenters' rights under Delaware law?

A:
If the merger is consummated, stockholders who do not vote in favor of the adoption of the merger agreement, who continuously hold such shares through the effective time of the merger, who have properly exercised, perfected and not validly withdrawn, waived or otherwise lost their rights to appraisal of their shares and who meet certain other conditions and statutory

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Q:
Will I be subject to U.S. federal income tax upon the exchange of Endocyte common stock for cash pursuant to the merger?

A:
If you are a U.S. holder (as defined under "The Merger (Proposal 1)—Material U.S. Federal Income Tax Consequences of the Merger" beginning on page 69), the exchange of our common stock for cash pursuant to the merger generally will require a U.S. holder to recognize a gain or loss for U.S. federal income tax purposes in an amount equal to the difference between the amount of cash received by such U.S. holder pursuant to the merger and such U.S. holder's adjusted tax basis in the shares of our common stock surrendered pursuant to the merger. Backup withholding may also apply to the cash payment pursuant to the merger unless the U.S. holder or other payee provides a taxpayer identification number, certifies that such number is correct and otherwise complies with the backup withholding rules. Because particular circumstances may differ, we recommend that you consult your own tax advisor to determine the U.S. federal income tax consequences relating to the merger in light of your own particular circumstances and any consequences arising under the laws of any state, local or foreign taxing jurisdiction. A more complete description of the U.S. federal income tax consequences of the merger is provided under "The Merger (Proposal 1)—Material U.S. Federal Income Tax Consequences of the Merger" beginning on page 69 of this proxy statement.

Q:
How do I attend the special meeting?

A:
If you are a stockholder of record as of the record date, you need to provide some form of government-issued photo identification (such as a valid driver's license or passport) for admission. If your shares are held in the name of a broker, bank or other nominee, you will need to present a recent brokerage statement or letter from such entity reflecting your stock ownership as of the record date and will need to provide some form of government-issued photo identification for admission to the special meeting. However, you may not vote your shares in person at the special meeting unless you follow your broker's, bank's or other nominee's procedures for obtaining a legal proxy and then present that legal proxy for verification at the special meeting.

Q:
How many shares are needed to constitute a quorum?

A:
A quorum will be present if holders of a majority of the shares of our common stock outstanding at the close of business on the record date are present in person or represented by proxy at the special meeting. If a quorum is not present at the special meeting, the special meeting may be adjourned or postponed from time to time until a quorum is obtained.

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Q:
What vote of Endocyte stockholders is required to adopt the merger agreement?

A:
Approval of the proposal to adopt the merger agreement requires the affirmative vote of the holders of a majority of the outstanding shares of our common stock entitled to vote thereon. A failure to vote your shares of our common stock or an abstention from voting will have the same effect as a vote "AGAINST" the proposal to adopt the merger agreement. If your shares are held in "street name" by your broker, bank or other nominee and you do not instruct the nominee how to vote your shares, such failure to instruct your nominee will have the same effect as a vote "AGAINST" the proposal to adopt the merger agreement. Note that you may vote to adopt the merger agreement and vote not to approve the advisory (non-binding) merger-related compensation proposal or adjournment proposal or vice versa.

Q:
What vote of Endocyte stockholders is required to approve the other proposals to be voted upon at the special meeting?

A:
Each of the advisory (non-binding) proposal to approve certain compensation that may be paid or become payable to the named executive officers of Endocyte in connection with the merger and the proposal to adjourn the special meeting, if necessary or appropriate, including to solicit additional proxies, requires the affirmative vote of a majority of the voting power of the shares of our common stock present in person or represented by proxy at the special meeting and entitled to vote thereon.
Q:
How does our board recommend that I vote?

A:
Our board (with respect to the first item below, based on the unanimous affirmative recommendation of the special committee of our board) unanimously recommends that our stockholders vote:

"FOR" the proposal to adopt the merger agreement;

"FOR" the advisory (non-binding) proposal to approve certain compensation that may be paid or become payable to our named executive officers in connection with the merger; and

"FOR" the proposal to adjourn of the special meeting, if necessary or appropriate, including to solicit additional proxies if there are insufficient votes at the time of the special meeting to approve the proposal to adopt the merger agreement.

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Q:
How do Endocyte's directors and officers intend to vote?

A:
We currently expect that our directors and executive officers will vote their shares in favor of the proposal to adopt the merger agreement and the other proposals to be considered at the special meeting, although they have no obligation to do so.

Q:
What will happen if stockholders do not approve the advisory (non-binding) proposal on certain compensation that may be paid or become payable to Endocyte's named executive officers in connection with the merger?

A:
The inclusion of this proposal is required by the SEC rules; however, the approval of this proposal is not a condition to the completion of the merger and the vote on this proposal is an advisory vote by stockholders and is not binding on Endocyte or Novartis. If the merger agreement is adopted by Endocyte stockholders and the merger is completed, the merger-related compensation will be paid to Endocyte's named executive officers in accordance with the terms of their compensation agreements and arrangements even if stockholders do not approve this proposal.

Q:
What do I need to do now? How do I vote my shares of our common stock?

A:
We urge you to read this entire proxy statement carefully, including its annexes and the documents incorporated by reference, and to consider how the merger affects you. Your vote is important, regardless of the number of shares of our common stock you own. See page i at the beginning of this proxy statement for instructions on how to vote your shares in person or by proxy over the Internet, by telephone or by mail.

Q:
Can I revoke my proxy?

A:
Yes. You may revoke your proxy and change your vote at any time before your proxy is voted at the special meeting. If you are a stockholder of record, you may revoke your proxy by (i) delivering a later-dated proxy in writing, over the telephone or via the Internet, and submitting it so that it is received prior to the cut-off time in accordance with the instructions included in the proxy card; (ii) delivering a written notice of revocation to our Corporate Secretary, Endocyte, Inc., 8910 Purdue Road, Suite 250, Indianapolis, Indiana 46268 that is received prior to the special meeting, stating that you revoke your proxy; or (iii) attending the special meeting and voting in person. If you hold your shares in "street name" and you have instructed a broker, bank or other nominee to vote your shares, you should instead follow the instructions received from your broker, bank or other nominee to revoke your prior voting instructions.

Q:
Will my shares of Endocyte common stock held in "street name" or another form of record ownership be combined for voting purposes with shares I hold of record?

A:
No. Because any shares of our common stock you may hold in "street name" will be deemed to be held by a different stockholder (that is, your custodial bank, broker or other financial nominee) than any shares of our common stock you hold of record, any shares of our common stock held in "street name" will not be combined for voting purposes with shares of our common stock you hold of record. Similarly, if you own shares of our common stock in various registered forms, such as jointly with your spouse, as trustee of a trust or as custodian for a minor, you will receive, and will need to sign and return, a separate proxy card, or submit your proxies separately by Internet or telephone, for those shares of our common stock because they are held in a different form of

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Q:
What does it mean if I get more than one proxy card or voting instruction card?

A:
If your shares of our common stock are registered differently or are held in more than one account, you will receive more than one proxy or voting instruction card. Please complete and return all of the proxy cards and voting instruction cards you receive (or submit each of your proxies by telephone or the Internet, if available to you) to ensure that all of your shares of our common stock are voted.

Q:
What happens if I sell my shares of Endocyte common stock before completion of the merger?

A:
In order to receive the merger consideration, you must hold your shares of our common stock through completion of the merger. Consequently, if you transfer your shares of our common stock before completion of the merger, you will have transferred your right to receive the merger consideration in the merger.
Q:
Should I send in my stock certificates or other evidence of ownership now?

A:
No. After the merger is completed, you will receive a letter of transmittal and related materials from the paying agent for the merger with detailed written instructions for exchanging your shares of our common stock evidenced by stock certificates for the merger consideration. If your shares of our common stock are held in "street name" by your broker, bank or other nominee, you may receive instructions from your broker, bank or other nominee as to what action, if any, you need to take to effect the surrender of your "street name" shares in exchange for the merger consideration. Do not send in your stock certificates now.

Q:
Where can I find the voting results of the special meeting?

A:
We intend to announce preliminary voting results at the special meeting and publish final results in a Current Report on Form 8-K that will be filed with the SEC following the special meeting. All reports that we file with the SEC are publicly available when filed. See "Where You Can Find Additional Information" on page 112 of this proxy statement.

Q:
Where can I find more information about Endocyte?

A:
You can find more information about us from various sources described in the section entitled "Where You Can Find Additional Information."

Q:
What is householding and how does it affect me?

A:
The SEC permits companies to send a single set of certain disclosure documents to stockholders who share the same address and have the same last name, unless contrary instructions have been received, but only if the applicable company provides advance notice and follows certain

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Q:
Who can help answer my other questions?

A:
If you have more questions about the merger or require assistance in submitting your proxy or voting your shares or need additional copies of this proxy statement or the enclosed proxy card, please contact MacKenzie Partners, Inc., which is acting as the proxy solicitation agent and information agent for Endocyte in connection with the merger.

MacKenzie Partners, Inc.
1407 Broadway
New York, NY 10018
Stockholders May Call:
(800) 322-2885 (toll-free from the U.S. or Canada);
(212) 929-5500 (from other locations)

        If your broker, bank or other nominee holds your shares, you should also call your broker, bank or other nominee for additional information.

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CAUTIONARY STATEMENT CONCERNING FORWARD-LOOKING STATEMENTS

        The Private Securities Litigation Reform Act of 1995 provides a "safe harbor" for certain forward-looking statements. This communication contains forward-looking statements, including statements relating to the completion of the merger and statements regarding Endocyte's future performance. Forward-looking statements can usually be identified by the use of words such as "aim," "anticipate," "believe," "continue," "could," "estimate," "evolve," "expect," "forecast," "intend," "looking ahead," "may," "opinion," "plan," "possible," "potential," "project," "should," "will" and other expressions which indicate future events or trends. These forward-looking statements are based on the companies' current plans, expectations and assumptions and involve a number of risks and uncertainties that could cause actual results and events to vary materially from the results and events anticipated or implied by such forward-looking statements.

        These risks and uncertainties include, but are not limited to, the following factors:

        Many of these factors are beyond our ability to control or predict. In light of the significant uncertainties inherent in the forward-looking statements contained herein, readers should not place undue reliance on forward-looking statements, which speak only as of the date hereof. We cannot guarantee any future results, levels of activity, performance or achievements. Except as required by applicable law, we undertake no obligation to update forward-looking statements to reflect events or circumstances arising after such date.

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THE COMPANIES

Endocyte, Inc.

        Endocyte, Inc., referred to as "Endocyte," the "Company," "we," "our" or "us," is a Delaware corporation. Endocyte was incorporated in the State of Indiana in 1995 and was reincorporated in the State of Delaware in 2001. We are a biopharmaceutical company and leader in developing targeted therapies for the treatment of cancer. We use drug conjugation technology to create novel therapeutics and companion imaging agents for personalized targeted therapies. Our agents actively target receptors that are over-expressed on diseased cells relative to healthy cells, such as prostate specific membrane antigen ("PSMA") in prostate cancer. This targeted approach is designed to safely enable the delivery of highly potent drug payloads. The companion imaging agents are designed to identify patients whose disease over-expresses the target of the therapy and who are therefore more likely to benefit from treatment.

        Our lead program is a PSMA-targeted radioligand therapy, 177Lu-PSMA-617, in phase 3 for metastatic castration-resistant prostate cancer for PSMA-positive patients. We also expect to have an Investigational New Drug application submitted in the fourth quarter of 2018 for our adaptor-controlled CAR T-cell therapy which will be studied initially in osteosarcoma.

        Our common stock is currently listed on the Nasdaq Global Market under the ticker symbol "ECYT."

        Our principal executive offices are located at 3000 Kent Avenue, Suite A1-100, West Lafayette, Indiana 47906, and our telephone number is (765) 463-7175. Endocyte's website is www.endocyte.com. The information contained on, or accessible through, our website is not incorporated into, and does not form a part of, this proxy statement or any other report or document on file with or furnished to the SEC.

Novartis AG

        Novartis AG, referred to as "Novartis" or "Buyer," was incorporated on February 29, 1996 under the laws of Switzerland as a stock corporation (Aktiengesellschaft) with an indefinite duration. On December 20, 1996, the predecessor companies of Buyer, Ciba-Geigy and Sandoz, merged into a new entity, creating the Novartis Group. Buyer is domiciled in and governed by the laws of Switzerland. Its registered office is located at Lichtstrasse 35, CH-4056 Basel, Switzerland, and its telephone number is +41-61-324-1111. The following description of Buyer and its business is qualified in its entirety by reference to Buyer's Annual Report on Form 20-F for the fiscal year ended December 31, 2017 and its Registration Statement on Form F-4 filed with the SEC on December 23, 2010, as amended.

        The Novartis Group is a multinational group of companies specializing in the research, development, manufacturing and marketing of a broad range of healthcare products led by innovative pharmaceuticals. Buyer is the Novartis Group's Swiss holding company and owns, directly or indirectly, all of the Novartis Group's significant operating companies.

        As a leading global medicines company, the Novartis Group uses innovative science and digital technologies to create transformative treatments in areas of great medical need. Its broad portfolio includes innovative pharmaceuticals and oncology medicines, generic and biosimilar medicines and eye care devices. The Novartis Group's continuing operations comprise corporate activities and three global operating divisions, Innovative Medicines, Sandoz and Alcon, which are further described below:

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        In addition, these divisions are supported by the following cross-divisional organizational units: Novartis Institutes for BioMedical Research, Global Drug Development and Novartis Operations, which includes Novartis Technical Operations, Novartis Business Services and Novartis Corporate Affairs.

        Buyer's shares are listed in Switzerland on the SIX Swiss Exchange under the symbol "NOVN", and its American Depositary Shares, each of which represents one Novartis share and is evidenced by an American Depositary Receipt, are traded on the New York Stock Exchange under the symbol "NVS".

Edinburgh Merger Corporation

        Edinburgh Merger Corporation, referred to as "Merger Sub," is a Delaware corporation and a wholly owned subsidiary of Novartis. Merger Sub was formed in October 2018 solely for the purpose of entering into the merger agreement and consummating the transactions contemplated by the merger agreement, and it currently has no other business or operations. Novartis expects that, immediately prior to the effective time, Merger Sub will be a direct, wholly owned subsidiary of Novartis Corporation, a New York corporation and a wholly owned subsidiary of Novartis. Upon completion of the merger, Merger Sub will cease to exist and Endocyte will continue as the surviving corporation.

        Merger Sub's principal executive offices are located at 230 Park Avenue, 21st Floor, New York, New York 10169, and its telephone number is (212) 830-2414.


THE SPECIAL MEETING

        We are furnishing this proxy statement to Endocyte stockholders as part of the solicitation of proxies by our board for use at the special meeting or any adjournment or postponement thereof. This proxy statement provides Endocyte stockholders with information about the special meeting and should be read carefully and in its entirety.

Date, Time and Place of the Special Meeting

        This proxy statement is being furnished to our stockholders as part of the solicitation of proxies by our board for use at the special meeting to be held at [                        ], on [                ], 2018 at [            ] local time, or at any adjournment or postponement thereof.

        To attend the meeting, you will need to present a valid government-issued photo identification, such as a driver's license or passport. If your shares are held in the name of a broker, bank or other nominee, you will need to present a recent brokerage statement or letter from such entity reflecting your stock ownership as of the record date.

Purposes of the Special Meeting

        At the special meeting, Endocyte stockholders will be asked to consider and vote on the following proposals:

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        Our stockholders must approve the proposal to adopt the merger agreement for the merger to occur. If our stockholders fail to adopt the merger agreement, the merger will not occur. A copy of the merger agreement is attached to this proxy statement as Annex A, and the material provisions of the merger agreement are described in the section entitled "The Merger Agreement."

        The vote on certain compensation that may be paid or become payable in connection with the merger is a vote separate and apart from the vote to adopt the merger agreement. Accordingly, a stockholder may vote to approve the compensation proposal and vote not to adopt the merger agreement and vice versa. Because the vote on the compensation proposal is advisory in nature only, it will not be binding on either Endocyte or Novartis. Accordingly, if the proposal to adopt the merger agreement is approved by Endocyte stockholders and the merger is completed, the merger-related compensation may be paid to Endocyte's named executive officers even if the stockholders fail to approve the proposal related to compensation payable in connection with the merger.

        Endocyte does not expect a vote to be taken on any other matters at the special meeting or any adjournment or postponement thereof. If any other matters are properly presented at the special meeting or any adjournment or postponement thereof for consideration, however, the holders of the proxies will have discretion to vote on these matters in accordance with their best judgment.

        This proxy statement and the enclosed proxy card are first being mailed to Endocyte stockholders on or about [                        ], 2018.

Record Date and Quorum

        The holders of record of our common stock as of the close of business on [                        ], 2018, the record date for the special meeting, are entitled to receive notice of and to vote at the special meeting. At the close of business on the record date, [                        ] shares of our common stock were outstanding.

        The presence at the special meeting, in person or represented by proxy, of the holders of a majority of our common stock outstanding at the close of business on the record date will constitute a quorum. Once a share is represented at the special meeting, it will be counted for the purpose of determining a quorum at the special meeting. However, if a new record date is set for an adjourned special meeting, then a new quorum will have to be established. Proxies received but marked as abstentions will be included in the calculation of the number of shares considered to be present at the special meeting. Broker non-votes will not count for the purpose of determining whether a quorum is present. A broker non-vote occurs when a broker, bank, trustee or nominee holding shares for a beneficial owner does not vote on a particular proposal because the broker or nominee does not have discretionary authority to vote for that particular proposal and has not received instructions from the beneficial owner as to how to vote its shares.

Required Vote

        Each share of our common stock outstanding at the close of business on the record date is entitled to one vote on each of the proposals to be considered at the special meeting.

        Approval of the proposal to adopt the merger agreement requires the affirmative vote of the holders of a majority of the outstanding shares of our common stock entitled to vote thereon. With respect to this proposal, you may vote "FOR," "AGAINST" or "ABSTAIN." A failure to vote your shares of our common stock or an abstention from voting will have the same effect as a vote "AGAINST" the proposal to adopt the merger agreement. If your shares are held in "street name" by your broker, bank or other nominee and you do not instruct the nominee how to vote your shares, such failure to instruct your nominee will have the same effect as a vote "AGAINST" the proposal to adopt the merger agreement.

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        Assuming a quorum is present, approval of the advisory (non-binding) proposal on certain compensation that may be paid or become payable to Endocyte's named executive officers in connection with the merger requires the affirmative vote of a majority of the voting power of the shares of our common stock present in person or represented by proxy at the special meeting and entitled to vote thereon. With respect to this proposal, you may vote "FOR," "AGAINST" or "ABSTAIN." For purposes of this proposal, abstentions will be counted in tabulating the votes cast and will have the same effect as a vote "AGAINST" the proposal. Broker non-votes will not be counted in tabulating the votes cast and will not have an effect on this proposal. If you fail to submit a proxy or vote in person at the special meeting, the shares of our common stock not voted will not be counted in respect of, and will not have an effect on, the advisory proposal on certain compensation.

        Approval of the proposal to adjourn the special meeting, if necessary or appropriate, including to solicit additional proxies if there are insufficient votes at the time of the special meeting to approve the proposal to adopt the merger agreement, requires the affirmative vote of a majority of the voting power of the shares of our common stock present in person or represented by proxy at the special meeting and entitled to vote thereon. With respect to this proposal, you may vote "FOR," "AGAINST" or "ABSTAIN." For purposes of this proposal, abstentions will be counted in tabulating the votes cast and will have the same effect as a vote "AGAINST" the proposal. Broker non-votes will not be counted in tabulating the votes cast and will not have an effect on the proposal to adjourn the special meeting. If you fail to submit a proxy or vote in person at the special meeting, the shares of our common stock not voted will not be counted in respect of, and will not have an effect on, the proposal to adjourn the special meeting.

Voting by Endocyte's Directors and Executive Officers

        At the close of business on the record date, our directors and executive officers were entitled to vote approximately [        ] shares of our common stock, which in the aggregate represented approximately [        ]% of the shares of our common stock issued and outstanding on that date. We currently expect that our directors and executive officers will vote their shares in favor of the proposal to adopt the merger agreement and the other proposals to be considered at the special meeting, although they have no obligation to do so.

Voting; Proxies; Revocation

Attendance

        A form of government-issued photo identification (such as a valid driver's license or passport) will be required for admission to the meeting. Only stockholders who owned Endocyte common stock as of the close of business on [            ], 2018, the record date, are entitled to attend the meeting.

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Voting in Person

        Stockholders of record will be able to vote in person at the special meeting. We will give you a ballot when you arrive. If you are not a stockholder of record but instead hold your shares of our common stock in "street name" through a broker, bank or other nominee, you must provide a legal proxy executed in your favor from your broker, bank or other nominee in order to be able to vote in person at the special meeting. Upon verification of your legal proxy, you will be provided a ballot to vote at the special meeting. Attending the meeting in person does not itself constitute a vote on any proposal.

Providing Voting Instructions by Proxy

        To ensure that your shares of our common stock are voted at the special meeting, we recommend that you provide voting instructions promptly by proxy, even if you plan to attend the special meeting in person.

        If you are a stockholder of record, you may provide voting instructions by proxy using one of the methods described below.

        To vote over the Internet, go to the web address [                        ] and follow the instructions for voting. Have your proxy card available when you access the web page. If you vote over the Internet, please do not mail your proxy card.

        To vote by telephone, dial [            ] in the United States or [            ] for international callers from any touch-tone telephone and follow the instructions. Have your proxy card available when you call. If you vote by telephone, please do not mail your proxy card.

        To vote by mail, mark your proxy card, date and sign it and return it in the postage-prepaid envelope. You should not return your stock certificate or send documents representing our common stock with the proxy card. If the merger is completed, the paying agent for the merger will send you a letter of transmittal and related materials and instructions for exchanging your shares of our common stock for the merger consideration.

        If you vote by proxy (regardless of whether you vote over the Internet, by telephone or by mail), your votes must be received by 11:59 p.m., Eastern Time, on [                        ], 2018 to be counted.

        Your proxy card will count as a "vote" if you sign, date and return your proxy card without indicating how you wish to vote with respect to a proposal. In this case, your proxy will be voted "FOR" such proposal.

        A failure to vote or an abstention will have the same effect as voting "AGAINST" the proposal to adopt the merger agreement. A failure to vote will not have the effect of either a vote "FOR" or "AGAINST" the other two proposals, but an abstention will have the same effect as voting "AGAINST" the other two proposals.

        If you hold your shares in "street name" through a broker, bank or other nominee, you should follow the directions provided by your broker, bank or other nominee regarding how to instruct your broker, bank or other nominee to vote your shares. Without those instructions, your shares will not be voted on any of the proposals, which will have the same effect as voting "AGAINST" the proposal to adopt the merger agreement, but, assuming a quorum is present, will not have the effect of either a vote "FOR" or a vote "AGAINST" on the other two proposals.

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        Brokers, banks and other nominees that hold shares of our common stock in "street name" for their customers do not have discretionary authority to vote the shares with respect to the proposal to adopt the merger agreement, the advisory (non-binding) proposal to approve certain compensation that may be paid or become payable to our named executive officers in connection with the merger, or the adjournment of the special meeting, if necessary or appropriate, including to solicit additional proxies. Accordingly, if brokers, banks or other nominees do not receive specific voting instructions from the beneficial owner of such shares, they may not vote such shares with respect to these proposals. Therefore, unless you attend the special meeting in person with a properly executed legal proxy from your broker, bank or other nominee, your failure to provide instructions to your broker, bank or other nominee will result in your shares of our common stock not being present at the meeting and not being voted on any of the proposals, which will have the effect of a vote "AGAINST" with respect to the proposal to adopt the merger agreement.

Revocation of Proxies

        Any person giving a proxy pursuant to this solicitation has the power to revoke and change it at any time before it is voted. If you are a stockholder of record, you may revoke your proxy by:

Please note that only your last-dated proxy will count. Attending the special meeting without taking one of the actions described above will not in itself revoke your proxy.

        Please note that if you hold your shares in "street name" and you have instructed a broker, bank or other nominee to vote your shares, you should instead follow the instructions received from your broker, bank or other nominee to revoke your prior voting instructions.

Abstentions

        An abstention occurs when a stockholder attends a meeting, either in person or represented by proxy, but abstains from voting. Abstentions will be included in the calculation of the number of shares of our common stock present or represented at the special meeting for purposes of determining whether a quorum has been achieved. Abstaining from voting will have the same effect as a vote "AGAINST" all three proposals.

Special Committee's and Board of Directors' Recommendation

        The special committee of our board, after considering various factors described in the section entitled "The Merger (Proposal 1)—Reasons for the Recommendation of the Special Committee and our Board," unanimously (i) determined that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and its stockholders, (ii) approved and declared advisable the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement, and (iii) recommended that our Board approve the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement.

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        Our board, after considering various factors described in the section entitled "The Merger (Proposal 1)—Reasons for the Recommendation of the Special Committee and our Board," unanimously (upon the recommendation of the special committee of our board) (i) determined that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and its stockholders; (ii) approved and declared advisable the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement; (iii) approved the execution, delivery and performance by Endocyte of the merger agreement and the consummation of the transactions contemplated thereby, including the merger; and (iv) recommended that the holders of Endocyte common stock adopt the merger agreement and directed that the merger agreement be submitted to Endocyte's stockholders at a special meeting of stockholders of Endocyte.

        Our Board unanimously recommends that you vote (1) "FOR" the proposal to adopt the merger agreement, (2) "FOR" the advisory (non-binding) proposal to approve certain compensation that may be paid or become payable to the named executive officers of Endocyte in connection with the merger, and (3) "FOR" the proposal to adjourn the special meeting, if necessary or appropriate, including to solicit additional proxies.

List of Stockholders

        A list of stockholders entitled to vote at the special meeting will be available for examination by any stockholder for any purpose germane to the special meeting, both at the special meeting and for ten days prior to the special meeting, by contacting our Corporate Secretary at our offices at 8910 Purdue Road, Suite 250, Indianapolis, Indiana 46268.

Solicitation of Proxies

        Our board is soliciting your proxy, and we will bear the cost of this solicitation of proxies. This includes the charges and expenses of brokerage firms and others for forwarding solicitation material to beneficial owners of our outstanding common stock. We have retained MacKenzie Partners, Inc. ("MacKenzie"), a proxy solicitation firm, to assist our board in the solicitation of proxies for the special meeting, and we expect to pay MacKenzie $25,000, plus reimbursement of out-of-pocket expenses. We have also agreed to indemnify MacKenzie against losses arising out of its provision of these services on our behalf. Directors, officers and employees of ours may also solicit proxies by telephone, by email, by mail, on the Internet or in person. They will not be paid any additional amounts for soliciting proxies.

Other Business

        We are not currently aware of any business to be acted upon at the special meeting other than the matters discussed in this proxy statement. Under our by-laws, business transacted at the special meeting is limited to matters relating to the purposes stated in the notice of the special meeting, which is provided at the beginning of this proxy statement. The grant of a proxy will confer discretionary authority on the persons named as proxies on the proxy card to vote in accordance with their best judgment on procedural matters incident to the conduct of the special meeting.

Notice Regarding the Availability of Proxy Materials for the Special Meeting to be Held on [                        ], 2018

        The proxy statement is available at [                                    ].

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THE MERGER (PROPOSAL 1)

        The description of the merger in this section and elsewhere in this proxy statement is qualified in its entirety by reference to the complete text of the merger agreement, a copy of which is attached as Annex A and is incorporated by reference into this proxy statement. This summary does not purport to be complete and may not contain all of the information about the merger that is important to you. You are encouraged to read the merger agreement carefully and in its entirety.

Certain Effects of the Merger

        If the proposal to adopt the merger agreement is approved by our stockholders and the other conditions to the closing of the merger are either satisfied or waived, Merger Sub will be merged with and into Endocyte, and the separate corporate existence of Merger Sub will cease. Endocyte will be the surviving corporation in the merger and will continue its corporate existence as a Delaware corporation and a wholly owned subsidiary of Novartis.

        Upon the terms and subject to the conditions of the merger agreement, at the effective time, each share of our common stock issued and outstanding immediately before the effective time (other than excluded shares and appraisal shares) will be converted into the right to receive $24.00 in cash, without interest, less any applicable withholding taxes. At the effective time of the merger, our current stockholders will cease to have ownership interests in Endocyte or rights as its stockholders. Therefore, our current stockholders will not participate in any of our future earnings or growth and will not benefit from any appreciation in our value.

        At the effective time, each Endocyte stock option that is outstanding and unexercised immediately prior to the effective time, whether vested or unvested, will (i) if the exercise price of such option is less than the merger consideration, be canceled, with the holder of such stock option becoming entitled to receive an amount in cash, without interest, equal to (a) the excess of the merger consideration over the exercise price of the option, multiplied by (b) the number of shares of our common stock subject to such option as of immediately prior to the effective time (subject to any applicable withholding taxes); or (ii) if the exercise price of such option is equal to or greater than the merger consideration, be canceled without any consideration being payable. In addition, at the effective time, each Endocyte RSU that is outstanding and not settled immediately prior to the effective time, whether vested or unvested, will be canceled and converted into the right to receive an amount in cash, without interest, equal to the merger consideration multiplied by the number of shares of our common stock subject to such RSU as of immediately prior to the effective time (subject to any applicable withholding taxes).

        Our common stock is currently registered under the Exchange Act and is quoted on the Nasdaq Global Market under the symbol "ECYT." As a result of the merger, Endocyte will cease to be a publicly traded company and will be a wholly owned subsidiary of Novartis. Following the consummation of the merger, our common stock will be delisted from the Nasdaq Global Market and deregistered under the Exchange Act, and Endocyte will no longer be required to file periodic reports with the SEC with respect to our common stock, in each case in accordance with applicable law, rules and regulations.

Effects on Endocyte if the Merger is Not Completed

        If the proposal to adopt the merger agreement is not approved by our stockholders or if the merger is not consummated for any other reason, our stockholders will not receive any payment for their shares of common stock. Instead, we will remain a public company, our common stock will continue to be listed and traded on the Nasdaq Global Market and registered under the Exchange Act and we will continue to file periodic reports with the SEC. In addition, if the merger is not completed, we expect that management will operate the business in a manner similar to that in which it is being operated today and that our stockholders will continue to be subject to the same risks and

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opportunities as they currently are, including, among other things, general industry, economic and market conditions. Accordingly, if the merger is not consummated, there can be no assurance as to the effect of these risks and opportunities on the future value of your shares of our common stock. From time to time, our board will evaluate and review our business operations, properties, dividend policy and capitalization, among other things, make such changes as are deemed appropriate and continue to seek to identify strategic alternatives to maximize stockholder value. If the proposal to adopt the merger agreement is not approved by our stockholders or if the merger is not consummated for any other reason, there can be no assurance that any other transaction acceptable to us will be offered or that our business, prospects or results of operations will not be adversely impacted.

        If the merger agreement is terminated, under specified circumstances, we may be required to pay Novartis a termination fee, or Novartis may be required to pay us a reverse termination fee, as described under "The Merger Agreement—Termination Fees and Expense Reimbursement."

Background of the Merger

        The following chronology summarizes the key meetings and events that led to the signing of the merger agreement. The following chronology does not purport to catalogue every conversation among the special committee, our board or the representatives of Endocyte or Novartis or any other parties.

        In the ordinary course of Endocyte's business, our board and management team review and discuss Endocyte's long-term business plan and regularly assess Endocyte's performance, strategies, risks and opportunities. As part of these ongoing efforts, our board and management team have periodically considered strategic alternatives to enhance stockholder value. In particular, our board and management team have considered a number of potential partnering and licensing relationships with third parties and other strategic transactions, including at times exploring a potential sale of Endocyte with the goal of enhancing stockholder value.

        Since Endocyte's inception, Endocyte has focused on the development of targeting ligand conjugate technology candidates. In June 2017, Endocyte discontinued clinical development of EC1456, its second-generation folate-targeted product candidate, and narrowed the focus of its phase 1 clinical development of EC1169, a PSMA-targeted product candidate, to include only the cohort of taxane-exposed mCRPC patients, which completed enrollment in October 2017. In the fourth quarter of 2017, Endocyte determined not to invest further resources in the development of EC1169 beyond the completion of the phase 1 taxane-exposed cohort. In addition, in June 2017, Endocyte reduced its workforce by approximately 40% to align resources to focus on its highest value opportunities while maintaining key capabilities. In the third quarter of 2017, the closing price for Endocyte common stock reached a low of $1.17 per share.

        On September 29, 2017, Endocyte entered into a development and license agreement (the "ABX license agreement") with ABX advanced biochemical compounds—Biomedizinische Forschungsreagenzien GmbH ("ABX"), pursuant to which Endocyte acquired exclusive worldwide rights to develop and commercialize PSMA-617 agents, including the drug candidate known as 177Lu-PSMA-617, a radioligand therapeutic. As consideration for the exclusive license, on September 29, 2017, Endocyte made an upfront cash payment of approximately $11.9 million to ABX, consisting of $12.0 million less an immaterial expense reimbursement amount, and issued to ABX 2,000,000 shares of our common stock and warrants to purchase, in the aggregate, 4,000,000 shares of our common stock. The ABX license agreement obligates Endocyte to pay ABX regulatory milestone payments of up to $25.0 million, sales milestone payments of up to $135.0 million, and tiered royalties based on percentages of net sales beginning in the mid-teens and not to exceed the mid-twenties. Endocyte and ABX publicly announced the licensing of PSMA-617 from ABX to Endocyte on October 2, 2017. Endocyte's closing stock price on October 2, 2017 was $3.63 per share.

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        On October 18, 2017, Prakash Raman, the then Global Head of Oncology Business Development and Licensing at Novartis, and Nigel Sheail, Global Head of Mergers & Acquisitions and Business Development & Licensing at Novartis, spoke by telephone with Michael Sherman, Endocyte's Chief Executive Officer, Michael Andriole, Endocyte's Chief Financial Officer, and Matt Call, Endocyte's Vice President of Business Development. On that telephone call, Messrs. Raman and Sheail expressed an interest in learning more about PSMA-617. The parties agreed to stay in contact, although no formal follow-up meetings or calls were scheduled.

        On November 15, 2017, Mr. Sherman spoke with Mr. Sheail by telephone to discuss the potential strategic fit between Novartis and Endocyte. They agreed to meet in-person at an industry conference in January 2018 to continue their conversation.

        On January 8, 2018, representatives of Novartis, including Messrs. Sheail and Raman, met in-person with representatives of Endocyte, including Messrs. Sherman, Andriole and Call, to further discuss Novartis' interest in PSMA-617. The Endocyte representatives provided an update on Endocyte's program developments since October 2017, including clinical trial plans. The Endocyte representatives also presented information regarding the key attributes of Endocyte's CAR-T cell therapy program.

        Also on January 8, 2018, Messrs. Andriole and Call had an in-person meeting with executives from a pharmaceutical and biotechnology company (referred to in this proxy statement as "Party A") to discuss a potential partnership between Party A and Endocyte with respect to PSMA-617 in certain geographies outside of the United States. Party A indicated shortly thereafter that it was not interested in any such partnership with respect to PSMA-617.

        On February 26, 2018, Endocyte issued press releases announcing the design of its Phase 3 VISION trial for 177Lu-PSMA-617 and an agreement between Endocyte and a third party for clinical supply of no-carrier-added Lutetium for the manufacture of 177Lu-PSMA-617 for use in Endocyte's Phase 3 VISION trial.

        On February 28, 2018, Endocyte announced that it had priced an underwritten public offering of our common stock at a public offering price of $4.20 per share, pursuant to which Endocyte received aggregate net proceeds of approximately $80.9 million, after deducting underwriting discounts and commissions and offering expenses. This offering closed on March 2, 2018.

        On March 16, 2018, Messrs. Raman and Sheail spoke by telephone with Messrs. Sherman and Andriole to discuss the potential for a strategic fit between Endocyte and Novartis and various possible transactions in which Novartis and Endocyte might engage, including a potential acquisition of Endocyte by Novartis. Messrs. Raman and Sheail expressed a potential interest in delivering a transaction proposal to Endocyte management. Messrs. Raman and Sheail also discussed with Mr. Sherman the anticipated timing of U.S. Food and Drug Administration ("FDA") approval of 177Lu-PSMA-617.

        On March 16, 2018, following the telephone call between Messrs. Raman and Sheail and Messrs. Sherman and Andriole, Mr. Andriole informed a representative of Centerview, Endocyte's financial advisor, of the potential of an offer from Novartis to acquire Endocyte. Endocyte determined to select Centerview as its financial advisor based on Centerview's reputation and experience and in consideration of Centerview's existing relationships with Novartis that Centerview had previously disclosed orally to Endocyte.

        On March 22, 2018, our board held a telephonic update call, with representatives of Faegre Baker Daniels LLP ("FaegreBD"), Endocyte's outside legal counsel, in attendance. Mr. Sherman discussed with our board Novartis' interest in a potential acquisition of Endocyte. During that update call, a representative of FaegreBD advised the directors of their fiduciary duties in connection with evaluating a potential change of control transaction.

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        On April 20, 2018, Mr. Raman informed Mr. Sherman that members of Novartis management had considered a potential acquisition of Endocyte and that a formal written proposal would be forthcoming on or around April 27, 2018.

        On April 27, 2018, Messrs. Raman and Sheail called Mr. Sherman and proposed a non-binding offer for an all-cash acquisition of Endocyte by Novartis at a price of $12.50 per share of our common stock (the "April 27 Non-Binding Offer"), subject to Novartis' satisfactory completion of due diligence and other customary conditions, and indicated that a letter to that effect would be sent the following week. Mr. Sherman indicated that he would discuss the April 27 Non-Binding Offer with our board, but that he did not believe our board would be receptive to a transaction at that price. The closing price per share of our common stock on April 26, 2018, the last full trading day prior to the April 27 Non-Binding Offer, was $9.33.

        On April 28, 2018, at the direction of Endocyte management, a representative of Centerview had a preliminary call with representatives of Novartis to discuss the April 27 Non-Binding Offer that had been communicated orally to Mr. Sherman the previous day.

        On April 30, 2018, at the direction of Endocyte management, a Centerview representative discussed the April 27 Non-Binding Offer with Mr. Sheail and informed Mr. Sheail that Endocyte would be holding a regularly scheduled board meeting on May 3, 2018.

        On April 30, 2018, Mr. Sheail had a telephone call with Mr. Sherman. Mr. Sherman informed Mr. Sheail that he had discussed the April 27 Non-Binding Offer with Centerview and that Mr. Sherman was supportive of presenting a proposal to our board. Mr. Sherman proposed, however, that Novartis revise its proposal to increase its offer price and that Novartis memorialize the revised proposal in a letter to be sent to Mr. Sherman before the May 3, 2018 meeting of our board. In his conversation with Mr. Sheail, Mr. Sherman indicated that he did not believe that our board would be interested in a transaction at the price offered in the April 27 Non-Binding Offer, but that our board may be willing to provide Novartis with limited initial due diligence subject to entering into a confidentiality agreement.

        Also on April 30, 2018, following the telephone call between Mr. Sheail and Mr. Sherman, Mr. Sheail, in separate phone calls, informed both a Centerview representative and Mr. Sherman that Novartis would increase its proposed non-binding offer price to $13.00 per share of our common stock and memorialize the revised proposal in a letter to be sent to Mr. Sherman before the May 3, 2018 meeting of our board.

        On April 30, 2018, following the prior discussions between Mr. Sheail and each of Mr. Sherman and a Centerview representative, Mr. Sheail sent a letter to Mr. Sherman reflecting a non-binding offer for an all-cash acquisition of Endocyte by Novartis at a price of $13.00 per share of our common stock (the "April 30 Non-Binding Offer"), subject to Novartis' satisfactory completion of due diligence and other customary conditions. The closing price per share of our common stock on April 27, 2018, the last full trading day prior to the April 30 Non-Binding Offer, was $9.40.

        On May 3, 2018, Endocyte and Novartis entered into a confidentiality agreement (which did not include a standstill provision) and scheduled an in-person meeting to discuss the April 30 Non-Binding Offer to be held in London, England on May 4, 2018.

        Also on May 3, 2018, our board held a regularly scheduled meeting. Messrs. Andriole and Call and Dave McAvoy, Endocyte's general counsel, attended the meeting, as did representatives of FaegreBD and Centerview. Mr. Sherman provided an overview of the April 30 Non-Binding Offer. Representatives of FaegreBD summarized the fiduciary duties of the directors in connection with their review and consideration of the proposal and any potential acquisition of Endocyte. Representatives of Centerview presented a preliminary financial analysis of the April 30 Non-Binding Offer. Representatives of Centerview discussed with our board their historic relationship with Novartis. In

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recognition of the strong strategic fit between Novartis and Endocyte, our board expressed support for management to follow through with the scheduled meeting the next day in London, England.

        On May 4, 2018, members of Novartis' management team, including Messrs. Raman and Sheail, and a representative of PJT Partners Inc. ("PJT Partners"), Novartis' financial advisor, met with Messrs. Sherman and Andriole and a Centerview representative to discuss the April 30 Non-Binding Offer. Endocyte management explained its view of Endocyte's value and the assumptions underlying that view, and communicated that the April 30 Non-Binding Offer did not fully reflect that value. Endocyte management also presented certain information relating to Endocyte's business and operations. The Novartis representatives expressed continued interest in Endocyte and indicated that they would continue to assess their valuation of Endocyte including based on information presented by Endocyte at the meeting.

        On May 7, 2018 and May 8, 2018, representatives of Novartis and PJT Partners had several calls with a Centerview representative regarding, among other matters, potential transaction timing, certain due diligence matters and information relating to Endocyte's business and operations. The representatives of Novartis and PJT Partners and the Centerview representative also discussed the potential for certain of the information about Endocyte's business and operations to increase Novartis' valuation of Endocyte and result in Novartis increasing its proposed offer.

        On May 10, 2018, a PJT Partners representative informed a representative of Centerview that Novartis was considering providing a revised non-binding proposal with an increased offer price in the coming days.

        On May 11, 2018, in light of Philip Low's arrangements with Novartis over the past three years relating to scientific and therapeutic matters in connection with Dr. Low's work, which were wholly unrelated to the merger, as described further in the section entitled "The Merger (Proposal 1)—Interests of Endocyte's Directors and Executive Officers in the Merger—Certain Arrangements with Novartis," our board adopted resolutions appointing a special committee comprising all Endocyte directors other than Dr. Low. The special committee was authorized to consider and take action with respect to, and manage and oversee, a potential strategic transaction involving Endocyte.

        On May 11, 2018, a telephone call was held between representatives of Novartis, Messrs. Sherman and Andriole, Centerview representatives and PJT Partners representatives, to discuss certain due diligence matters.

        On May 15, 2018, a representative of PJT Partners informed a representative of Centerview that a potential revised non-binding proposal from Novartis may be communicated in the coming days.

        On May 18, 2018, Messrs. Sheail and Raman called Mr. Sherman to communicate Novartis' increased non-binding offer for an all-cash acquisition of Endocyte by Novartis at a price of $18.00 per share of our common stock (the "May 18 Non-Binding Offer"), subject to Novartis' satisfactory completion of due diligence and other customary conditions. Messrs. Sheail and Raman requested that Endocyte negotiate with Novartis on an exclusive basis so that Novartis could complete confirmatory due diligence quickly. Mr. Sherman communicated that he would update the special committee on the May 18 Non-Binding Offer. The closing price per share of our common stock on May 17, 2018, the last full trading day prior to the May 18 Non-Binding Offer, was $13.51.

        On May 18, 2018, following the call between Messrs. Sheail and Raman and Mr. Sherman, a PJT representative and a Centerview representative held a telephone call to discuss the May 18 Non-Binding Offer.

        On May 21, 2018, a meeting of the special committee was held to review the May 18 Non-Binding Offer. Messrs. Andriole, Call and McAvoy, and representatives of FaegreBD and Centerview, attended the meeting. A FaegreBD representative reminded the members of the special committee of the role

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and mandate of the special committee. Representatives of Centerview discussed with our board that Centerview had performed certain financial advisory services for Novartis on an ongoing basis with respect to matters unrelated to Endocyte. Centerview subsequently provided written disclosure to our board reflecting such discussion. Mr. Sherman updated the special committee on the interactions with Novartis since the last board meeting. The special committee discussed potential benefits as well as risks associated with exploring a sale of Endocyte at that time, and a Centerview representative discussed with the special committee Centerview's preliminary financial analysis of the May 18 Non-Binding Offer. The special committee and Endocyte management reviewed and discussed management's valuation model and the assumptions underlying the model. The special committee determined that the May 18 Non-Binding Offer was inadequate, but that it would be in the best interests of Endocyte and its stockholders to allow Novartis and its advisors to undertake a due diligence review of Endocyte on the basis that Novartis may increase its proposal as a result of its due diligence review.

        On May 22, 2018, Mr. Sherman called Messrs. Raman and Sheail to convey that the special committee had determined that the May 18 Non-Binding Offer was inadequate, but if Novartis believed it could identify additional value in the due diligence process, Endocyte would allow Novartis access to due diligence materials in an electronic data room over the coming weeks and would not provide similar due diligence access to any other third parties for a limited period of time given the accelerated timetable. Mr. Sherman and Messrs. Raman and Sheail also discussed potential timing for a transaction.

        On May 22, 2018, following the discussion between Mr. Sherman and Messrs. Raman and Sheail, a telephone call between a representative of Centerview and a representative of PJT Partners was held to discuss the May 18 Non-Binding Offer and expectations for due diligence.

        Also on May 22, 2018, Mr. Raman had a telephone call with Mr. Andriole to discuss a potential revised confidentiality agreement and certain due diligence matters. A representative of Novartis subsequently sent to Endocyte a draft revised confidentiality agreement that included a standstill provision.

        On May 23, 2018, representatives of each of Endocyte, Novartis, Centerview and PJT Partners had a telephone call regarding certain due diligence matters and transaction process including potential process for drafting and negotiating a merger agreement.

        Also on May 23, 2018, a representative of Cravath, Swaine & Moore LLP ("Cravath"), Novartis' outside legal counsel, discussed the terms of the confidentiality agreement with representatives of FaegreBD.

        Also on May 23, 2018, Centerview provided a report to our board and the special committee regarding Centerview's relationship with Novartis.

        On May 24, 2018, Endocyte and Novartis entered into the revised confidentiality agreement that included a standstill provision that falls away upon execution of a merger agreement with a third party. Endocyte subsequently granted data room access to Novartis and its advisors.

        On May 30, 2018, Cravath sent an initial draft of a merger agreement to FaegreBD.

        On June 3, 2018, Messrs. Sherman and Andriole met with representatives of Novartis, including Mr. Raman, for dinner during a scientific conference, to discuss the proposed transaction.

        On June 4, 2018, representatives of FaegreBD sent a revised draft of the merger agreement to Cravath.

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        Later on June 4, 2018, Mr. Raman called Mr. Sherman to inform him that Novartis had reservations about proceeding with the proposed transaction at that time due to ongoing regulatory and clinical dynamics.

        Also on June 4, 2018, the special committee held a meeting, with Mr. Andriole and representatives of FaegreBD attending. At the meeting, Mr. Sherman described Novartis' reservations with acquiring Endocyte as communicated to him by Mr. Raman. The special committee discussed this development and determined that, while Endocyte management should explore whether Novartis no longer has a continued interest at that time in pursuing a potential acquisition of Endocyte, it would be in the best interests of Endocyte and its stockholders for the management team to focus on executing Endocyte's clinical programs in the absence of any such continued interest from Novartis.

        On June 5, 2018, at the direction of Endocyte management, a representative of Centerview contacted Mr. Sheail and a representative of PJT Partners to discuss Novartis' reservations about proceeding with the proposed transaction at that time.

        On June 8, 2018, at the direction of Endocyte management, a Centerview representative proposed to Mr. Sheail and a representative of PJT Partners that Endocyte management hold a telephonic meeting with Novartis representatives to discuss any outstanding questions Novartis had regarding due diligence matters.

        On June 11, 2018, at the direction of Endocyte management, a representative of Centerview sent to Mr. Sheail and a representative of PJT Partners certain information prepared by Endocyte management to address Novartis' questions in advance of a telephonic meeting later that day.

        On June 12, 2018, on a telephone conference with Novartis representatives, Endocyte management responded to Novartis' questions regarding various items.

        During the period between June 12, 2018 and June 14, 2018, representatives of Centerview informed Endocyte management that two pharmaceutical and biotechnology companies (referred to in this proxy statement as "Party B" and "Party C"), each with an interest in new modalities in cancer treatment, including radio-ligand therapy, may have an interest in a potential acquisition of Endocyte. Based on Party B's and Party C's respective stated interest in the types of therapeutics under development by Endocyte, representatives of Centerview discussed with Endocyte management whether Centerview should propose that Party B and Party C contact Endocyte management directly regarding a potential acquisition of Endocyte. With the concurrence of Endocyte management, representatives of Centerview suggested that each of Party B and Party C contact Endocyte management to convey any interest directly.

        On June 18, 2018, a representative of Party C contacted Mr. Sherman to indicate Party C's interest in an acquisition of Endocyte. They agreed that an in-person meeting between the respective management teams of Endocyte and Party C should occur. The parties and their respective legal counsel began negotiating a confidentiality agreement.

        On June 20, 2018, an introductory call was held between representatives of Party B and Messrs. Sherman and Andriole. The parties and their respective legal counsel began negotiating the terms of a confidentiality agreement.

        On June 22, 2018, Mr. Raman emailed Mr. Sherman to further confirm its decision not to proceed with an acquisition of Endocyte at that time.

        On June 25, 2018, Party C and Endocyte entered into a confidentiality agreement containing a customary standstill provision that falls away upon execution of a merger agreement with a third party.

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        On June 26, 2018, Messrs. Sherman, Andriole and Call had an in-person meeting with representatives of Party C to provide a management presentation and general overview of Endocyte's drug candidates.

        On June 27, 2018, Endocyte and Party B entered into a confidentiality agreement, which did not contain a standstill provision.

        Later on June 27, 2018, Messrs. Sherman, Andriole and Call held a telephone conference with representatives of Party B to provide a general overview of Endocyte's drug candidates.

        On June 29, 2018, representatives of Centerview engaged in ordinary course discussions with representatives of a pharmaceutical and biotechnology company (referred to in this proxy statement as "Party D"), including with respect to Party D's interest in the high growth oncology industry. Based on Party D's interest in high growth, first-in-class oncology products and, at the prior suggestion of Endocyte management, during the course of such discussions, representatives of Centerview disclosed to Party D that Endocyte could be open to a potential strategic transaction with Party D.

        Later on June 29, 2018, Party B conveyed via email to representatives of Endocyte that it was interested in commencing a due diligence investigation of Endocyte.

        On June 30, 2018, Party C was given access to Endocyte's electronic data room.

        On July 2, 2018, Party B was given access to Endocyte's electronic data room.

        On July 2, 2018, Party D conveyed to representatives of Centerview that it was not interested in pursuing an acquisition of Endocyte.

        Also on July 2, 2018, representatives of Party C and members of Endocyte's management team had a telephone call to discuss certain matters relating to the manufacture and supply of 177Lu-PSMA-617.

        Later on July 2, 2018, the special committee held a meeting, with Messrs. Andriole and McAvoy, and representatives of FaegreBD and Centerview, in attendance. A representative of FaegreBD reminded the members of the special committee of their fiduciary duties in connection with their review of a strategic transaction. Mr. Sherman reported on communications with, and the current status of the due diligence being performed by, each of Party B and Party C. The Centerview representative then discussed with the special committee the transaction process to date, including possible interest from other potential acquirers. The special committee authorized Centerview to contact other potential acquirers of Endocyte to determine their potential interest in a transaction with Endocyte. The special committee approved the formal engagement of Centerview as financial advisor to Endocyte, and Endocyte and Centerview executed an engagement letter on July 3, 2018.

        On July 9, 2018 and July 16, 2018, Centerview provided written reports to the special committee regarding its historical and ongoing relationships with potential acquirers other than Novartis that might be contacted in connection with a potential sale of Endocyte.

        On July 10, 2018 and July 11, 2018, telephonic discussions were held between representatives of Endocyte and Party B relating to certain due diligence matters.

        On July 12, 2018, a telephonic discussion was held between representatives of Endocyte and Party C relating to certain due diligence matters.

        Also on July 12, 2018, at the direction of the special committee, representatives of Centerview contacted four additional parties that were considered to be potentially interested strategic acquirers by reason of having either an active clinical program in prostate cancer or expertise in radioligand therapies. Each of the four parties, after completing a preliminary evaluation of Endocyte's technologies, determined not to proceed with a potential acquisition of Endocyte. Endocyte did not enter into a confidentiality agreement with any of these parties.

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        On each of July 13, 2018 and July 17, 2018, representatives of Endocyte and Party B held a telephone call regarding certain manufacturing and supply matters.

        On July 19, 2018, our board held a meeting, with Messrs. Andriole and McAvoy and representatives of FaegreBD in attendance. Mr. Andriole updated our board on the status of a potential strategic transaction, including the status of due diligence being conducted by Party B and Party C, outreach efforts to determine possible interest from other potential strategic acquirers, expected timing for any potential offers and other related matters. The board then reviewed and discussed the reports by Centerview relating to their historical and ongoing relationships with potential acquirers of Endocyte.

        On July 30, 2018, a representative of Party C conveyed to a Centerview representative that Party C was working to revise its sales forecast of 177Lu-PSMA-617 and intended to provide feedback to Endocyte on such forecast.

        Also on July 30, 2018, Party B informed Endocyte that it was not interested in further pursuing an acquisition of Endocyte.

        On August 14, 2018, Party C communicated to a representative of Centerview that Party C was no longer interested in pursuing an acquisition of Endocyte. At this time, Endocyte was no longer in discussions with any party concerning a potential acquisition of Endocyte.

        On September 10, 2018, Endocyte publicly announced that the FDA supported Endocyte using radiographic progression-free survival as a regulatory endpoint for full approval in Endocyte's VISION trial of 177Lu-PSMA-617, which potentially accelerated the time to pivotal clinical trial data by one year, to the end of 2019, and potentially increased the probability of technical success in the trial.

        Also on September 10, 2018, Endocyte filed a preliminary prospectus with the SEC relating to the issuance of additional shares of our common stock.

        On September 11, 2018, Endocyte announced that it had priced an underwritten public offering of shares of our common stock at a public offering price of $18.50 per share, pursuant to which Endocyte received aggregate net proceeds of approximately $188.9 million, after deducting underwriting discounts and commissions and offering expenses. This offering closed on September 14, 2018.

        On September 13, 2018, David Gilman, Global Head of Oncology Business Development and Licensing and Portfolio Management at Novartis, contacted Mr. Sherman indicating that Novartis may have a renewed interest in a potential transaction with Endocyte in light of the recent announcement of the new regulatory endpoint for Endocyte's clinical trial. Mr. Sherman agreed to share supporting documentation regarding such new regulatory endpoint with Novartis in advance of a subsequent call to be scheduled between representatives of Novartis and Endocyte.

        On each of September 14, 2018 and September 18, 2018, Mr. Gilman contacted Mr. Sherman to discuss a potential transaction between Novartis and Endocyte, including ongoing analysis that Novartis was working on in connection with a potential transaction.

        On September 21, 2018, representatives of Novartis, including Messrs. Sheail and Gilman, called Messrs. Sherman and Andriole to indicate that Novartis would like to re-engage with Endocyte with respect to a potential acquisition of Endocyte. Mr. Sheail proposed a non-binding offer for an all-cash acquisition of Endocyte by Novartis at a price of $23.00 per share of our common stock (the "September 21 Non-Binding Offer"), subject to Novartis' satisfactory completion of due diligence and other customary conditions. Mr. Sherman noted that he would inform the special committee of the September 21 Non-Binding Offer. The September 21 Non-Binding Offer was subsequently confirmed in writing by a letter from Ms. Keren Haruvi, Global Head of Mergers and Acquisitions at Novartis, to Endocyte. The closing price per share of our common stock on September 20, 2018, the last full trading day prior to the September 21 Non-Binding Offer, was $17.63.

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        The special committee met on September 23, 2018, with Messrs. Andriole, Call and McAvoy and representatives from FaegreBD and Centerview in attendance. A representative from FaegreBD reminded the special committee members of their fiduciary duties in connection with their review of a potential sale of Endocyte. Mr. Sherman reported that Novartis had reinitiated contact with Endocyte to communicate a non-binding proposal to acquire Endocyte at an increased offer price. Mr. Sherman also provided the special committee with an update on communications with other potential buyers of Endocyte, all of which had declined to submit a proposal to acquire Endocyte. A representative from Centerview discussed a preliminary financial analysis of the September 21 Non-Binding Offer. Mr. Andriole and the Centerview representative provided a detailed review of management's valuation model, which had been revised as compared to an earlier version prepared at the time of the May 18 Non-Binding Offer to reflect updates to Endocyte's business and operations since that time. Management's valuation model is described in more detail in the section below entitled "Certain Endocyte Unaudited Prospective Financial Information." The special committee discussed the material risks, uncertainties and opportunities facing Endocyte if it were to remain a stand-alone company, and determined that it was in the best interests of Endocyte and its stockholders to re-engage in discussions with Novartis. The special committee authorized Endocyte management to re-engage in discussions with Novartis regarding Novartis' proposal. The special committee instructed Endocyte management to counter Novartis' proposal with a price of $27.00 per share of our common stock and to offer Novartis an exclusivity period of two weeks.

        On September 23, 2018, Mr. Sherman contacted representatives of Novartis to inform them of the counterproposal of $27.00 per share of our common stock and a two-week exclusivity period. The closing price per share of our common stock on September 21, 2018, the last full trading day prior to the counterproposal, was $17.53.

        On September 24, 2018, a Centerview representative received a call from a representative of Party C to discuss the FDA's support of radiographic progression-free survival as a regulatory endpoint for full approval in Endocyte's VISION trial of 177Lu-PSMA-617. The Party C representative confirmed that Party C was still not interested in pursuing an acquisition of Endocyte at that time.

        On September 25, 2018, Messrs. Sheail and Gilman held a telephone call with Mr. Sherman to submit a revised non-binding offer for an all-cash acquisition of Endocyte by Novartis at a price of $24.00 per share of our common stock (the "September 25 Non-Binding Offer"), subject to Novartis' satisfactory completion of due diligence and other customary conditions. Mr. Sherman conveyed that he expected that Novartis would find additional value beyond $24.00 per share as it completed its due diligence review of Endocyte. Novartis was subsequently granted access to Endocyte's electronic data room. The closing price per share of our common stock on September 24, 2018, the last full trading day prior to the September 25 Non-Binding Offer, was $18.24.

        On September 26, 2018, Centerview provided updated disclosure regarding its relationship with Novartis.

        During the following weeks, representatives of each of Endocyte, Novartis, Centerview, FaegreBD and Cravath held a series of calls regarding various due diligence matters in the course of Novartis performing due diligence on Endocyte.

        On October 8, 2018, representatives of Cravath sent a revised draft of the merger agreement to representatives of FaegreBD.

        Between October 8, 2018 and the execution of the merger agreement on October 17, 2018, representatives of FaegreBD and Cravath had a series of telephone calls to negotiate the terms of the merger agreement.

        Also on October 8, 2018, the special committee held a meeting, with Mr. Andriole and representatives of FaegreBD in attendance. Messrs. Sherman and Andriole reported on the status of

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Novartis' due diligence review. Representatives of FaegreBD provided an overview of the merger agreement and reminded the members of the special committee of their fiduciary duties in considering a potential transaction, and reviewed updated information regarding Centerview's historical and ongoing relationships with Novartis, which relationships had previously been disclosed in writing to the board in May 2018. In light of the increased likelihood that Endocyte would enter into a transaction with Novartis, the special committee determined to engage a second financial advisor that did not have material investment banking relationships with Novartis. The special committee determined, based on Jefferies' familiarity with Endocyte and its business and Jefferies' experience in mergers and acquisition transactions similar to the proposed transaction with Novartis, to direct management to engage Jefferies as a second financial advisor to provide additional financial perspectives to our board and the special committee regarding any potential transaction involving Novartis.

        On October 10, 2018, Mr. Sheail and Mr. Sherman had a telephonic discussion regarding the transaction process and potential timing for entering into a transaction.

        On October 11, 2018, representatives of FaegreBD delivered a revised draft of the merger agreement to representatives of Cravath.

        On October 12, 2018, Mr. Sheail and Mr. Sherman discussed the status of Novartis' due diligence review and the transaction process, including recent changes in stock market prices and the potential impact of such changes on the proposed merger consideration.

        Also on October 12, 2018, the special committee held a meeting with Messrs. Andriole, Call and McAvoy, and representatives of FaegreBD in attendance. Messrs. Sherman and Andriole updated the special committee on the status of Novartis' due diligence. A representative of FaegreBD reviewed for the special committee members the nature and scope of their fiduciary duties in connection with consideration of a transaction. A representative of FaegreBD also provided an update on the negotiations relating to the merger agreement. Mr. Andriole reported on the process of engaging Jefferies as a second financial advisor in accordance with the prior direction of the special committee, including that Jefferies had provided certain information for our board and the special committee that indicated that Jefferies had not provided financial advisory or financing services to Novartis during the prior two years. Subsequent to this special committee meeting, Endocyte engaged Jefferies as a financial advisor.

        On October 13, 2018, representatives of Cravath sent a revised draft of the merger agreement to FaegreBD.

        On October 15, 2018, Mr. Sheail and Mr. Sherman had a telephone call to discuss the status of due diligence and merger agreement negotiations. On this call, Mr. Sheail reaffirmed the $23.00 per share offer price included in the September 21 Non-Binding Offer and indicated that at that time and based on its valuation and due diligence analysis, Novartis would not increase its offer price to $24.00 per share or more. Mr. Sheail also made a proposal to reach agreement on a number of outstanding issues under the merger agreement. Mr. Sherman responded that he would discuss Mr. Sheail's proposal with the special committee. Mr. Sherman also indicated that Endocyte desired entering into a transaction, if any, in a timely manner in light of serious disruption to Endocyte's business that could occur in the event of a leak. Mr. Sheail's proposal as discussed orally by telephone was subsequently confirmed in writing, and later that day Cravath provided a revised merger agreement to FaegreBD reflecting the terms described by Mr. Sheail.

        On October 15, 2018, the special committee met with Messrs. Andriole and Call, and representatives of FaegreBD and representatives of Centerview, to discuss the $23.00 per share price and the revised merger agreement. A representative of FaegreBD reminded the special committee members of their fiduciary duties in connection with consideration of a potential transaction. After discussion, the special committee determined that it was in the best interests of Endocyte and its

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stockholders to continue working with Novartis to reach a mutually agreed transaction. The special committee authorized Endocyte management to further negotiate with Novartis to obtain transaction terms favorable to Endocyte including an increased offer price.

        On October 16, 2018, Mr. Sheail and Mr. Sherman held several conversations regarding Novartis' proposal and the terms of the merger agreement, and agreed in principle (subject to the approval of each party's board of directors and the Endocyte special committee) to an increase in the offer price per share from $23.00 to $24.00.

        On October 16, 2018, representatives of FaegreBD sent a revised draft of the merger agreement to representatives of Cravath. Representatives of Cravath and FaegreBD had a telephone call to discuss and resolve any outstanding issues in the merger agreement. Later that day, representatives of Cravath sent a further revised draft of the merger agreement to representatives of FaegreBD.

        Early on October 17, 2018, representatives of FaegreBD sent to Cravath a revised draft of the merger agreement.

        Later on October 17, 2018, Mr. Sheail and Mr. Sherman reached final agreement on terms of the merger agreement, and representatives of FaegreBD and Cravath then finalized the merger agreement.

        Shortly thereafter on October 17, 2018, the special committee and our board held a joint meeting with representatives of FaegreBD, Messrs. Andriole, Call and McAvoy and, for portions of the meeting, representatives of Centerview and Jefferies, in attendance. Representatives of FaegreBD reviewed with the special committee and our board their fiduciary duties as well as certain key legal terms of the merger agreement. Representatives of Centerview reviewed with the special committee and our board Centerview's financial analysis of the merger consideration of $24.00 per share, and rendered to the special committee and our board an oral opinion, which was subsequently confirmed by delivery of a written opinion dated October 17, 2018 that, as of such date and based upon and subject to various assumptions made, procedures followed, matters considered, and qualifications and limitations upon the review undertaken in preparing its opinion, the merger consideration to be paid to the holders of shares of our common stock (other than certain shares as specified in such opinion) pursuant to the merger agreement was fair, from a financial point of view, to such holders. Jefferies reviewed its financial analysis of the $24.00 per share merger consideration with our board and the special committee and rendered an oral opinion, confirmed by delivery of a written opinion dated October 17, 2018, to our board and the special committee to the effect that, as of that date and based on and subject to various assumptions made, procedures followed, matters considered and limitations and qualifications on the review undertaken as described in the opinion, the $24.00 per share merger consideration to be received by holders of Endocyte common stock (other than as specified in such opinion) pursuant to the merger agreement was fair, from a financial point of view, to such holders. Following additional discussion and consideration of the merger agreement and the transactions contemplated by the merger agreement, including the merger, the special committee unanimously: (i) determined that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and its stockholders, (ii) approved and declared advisable the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement, and (iii) recommended that our board approve the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement. Subsequently, our board (upon the unanimous affirmative recommendation of the special committee) unanimously: (a) determined that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and its stockholders; (b) approved and declared advisable the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger

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agreement; (c) authorized and approved the execution, delivery and performance by Endocyte of the merger agreement and the consummation of the transactions contemplated thereby, including the merger; and (d) recommended that the holders of shares of Endocyte common stock adopt the merger agreement and directed that the merger agreement be submitted to Endocyte's stockholders at a special meeting of stockholders of Endocyte. Representatives of FaegreBD also reviewed with our board a proposed amendment to Endocyte's bylaws regarding an exclusive forum bylaw. Following discussion, our board determined that the exclusive forum bylaw was in the best interests of Endocyte and its stockholders, and unanimously approved the exclusive forum bylaw. The compensation committee of our board also approved certain employment compensation, severance and other employee benefit arrangements with respect to the employees of Endocyte.

        Later in the day on October 17, 2018, Endocyte, Novartis, and Merger Sub executed the merger agreement.

        Before the opening of trading on the Nasdaq Global Market on October 18, 2018, Endocyte issued a press release announcing the execution of the merger agreement.

Reasons for the Recommendation of the Special Committee and our Board

        The special committee and our board carefully considered the merger agreement and the transactions contemplated by the merger agreement, including the merger, and consulted with Endocyte's management, as well as with Endocyte's outside legal and financial advisors. The special committee and our board took into account numerous factors, including, but not limited to, the material factors listed below. After careful consideration, including analysis by each of the special committee and our board of possible alternatives to the proposed transaction and the risks associated with such possible alternatives, the special committee, at a meeting described above on October 17, 2018, unanimously: (i) determined that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and its stockholders; (ii) approved and declared advisable the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement; and (iii) recommended that our board approve the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement. Subsequently, our board (upon the unanimous affirmative recommendation of the special committee), at a meeting described above on October 17, 2018, unanimously: (a) determined that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and its stockholders; (b) approved and declared advisable the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement; (c) authorized and approved the execution, delivery and performance by Endocyte of the merger agreement and the consummation of the transactions contemplated thereby, including the merger; and (d) recommended that the holders of Endocyte's common stock adopt the merger agreement and directed that the merger agreement be submitted to Endocyte's stockholders at a special meeting of stockholders of Endocyte. In connection with their respective determinations, the special committee and our board considered and evaluated a number of factors and benefits, including, but not limited to, the following material factors and benefits, each of which the special committee and our board believed supported their unanimous determinations:

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        The special committee and our board also considered in their deliberations a variety of uncertainties, risks and other potentially countervailing factors concerning the merger agreement and the transactions contemplated by the merger agreement, including the merger, including, but not limited to, the following:

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        In addition, the special committee and our board was aware of the fact that certain of Endocyte's officers and directors may have financial interests in the transactions contemplated by the merger agreement, including the merger, that are different from, or in addition to, those of Endocyte's stockholders generally, including those interests that are a result of employment and compensation arrangements with Endocyte. See "The Merger (Proposal 1)—Interests of Endocyte's Directors and Executive Officers in the Merger".

        The foregoing discussion of the information and factors considered by the special committee and our board is not meant to be exhaustive, but rather includes the material factors, information and analyses considered by the special committee and our board in reaching their respective recommendations. The special committee and our board each evaluated the various factors listed above in light of their knowledge of the business, financial condition and prospects of Endocyte and considered the views of Endocyte's management, as well as Endocyte's outside legal and financial advisors. In light of the number and variety of factors that the special committee and our board considered, the special committee and our board did not find it practicable to quantify, rank or otherwise assign relative weights to the foregoing factors and did not undertake to make any specific determination as to whether any particular factor, or any aspect of any particular factor, was favorable or unfavorable to the ultimate determination of the special committee and our board. Rather, each of the special committee's and our board's determination and recommendation was based upon the

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totality of the information considered. In addition, individual members of the special committee and our board may have given different weight or merit to different factors.

        The special committee and our board concluded that, overall, the potential benefits of the merger agreement and the merger to Endocyte's stockholders outweighed the uncertainties, risks and other potentially countervailing factors concerning the merger agreement and the merger.

        This explanation of the special committee's and our board's reasons for recommending the adoption of the merger agreement and other information presented in this section is forward-looking in nature and, therefore, should be read in light of the factors described in the section of this proxy statement entitled "Cautionary Statement Concerning Forward-Looking Statements".

Certain Endocyte Unaudited Prospective Financial Information

        Endocyte does not, as a matter of course, publicly disclose long-term projections or internal projections of its future financial performance, revenues, earnings, financial condition or other results given, among other reasons, the uncertainty of the underlying assumptions and estimates. However, in connection with the special committee's and our board's evaluation of the merger, certain non-public unaudited prospective financial information, including certain analyses and risk-adjusted financial forecasts and projections relating to Endocyte for fiscal years 2018 through 2035 (the "Projections"), were prepared by our management and provided to the special committee and our board. The Projections were also provided to Endocyte's financial advisors, Centerview and Jefferies, which were directed to use and rely upon the Projections in connection with their respective financial analyses and opinions summarized under "The Merger (Proposal 1)Opinion of Centerview Partners LLC" and "The Merger (Proposal 1)Opinion of Jefferies LLC," respectively.

        The Projections were not prepared with a view to public disclosure or toward compliance with generally accepted accounting principles as applied in the United States, which we refer to as GAAP, the published guidelines of the SEC regarding projections and forward-looking statements or the guidelines established by the American Institute of Certified Public Accountants for preparation and presentation of prospective financial information. Furthermore, our independent auditor has not examined, reviewed, compiled or otherwise performed any procedures with respect to the Projections, and accordingly assumes no responsibility for, and expresses no opinion or other form of assurance on, the Projections. The Projections included in this proxy statement have been prepared by, and are the responsibility of, Endocyte management. The Projections were prepared solely for internal use and are subjective in many respects. By including the Projections in this proxy statement, neither Endocyte nor any of its affiliates, officers, directors, advisors or other representatives has made or makes any representation to any person regarding the information included in the Projections or the ultimate performance of Endocyte or any of its affiliates compared to the information contained in the Projections. Endocyte has not made and makes no representation to Novartis or any Endocyte stockholder, in the merger agreement or otherwise, concerning the Projections or regarding Endocyte's actual performance compared to the Projections or that the Projections will be achieved. Endocyte urges all of its stockholders not to place undue reliance on the Projections and to review Endocyte's most recent SEC filings for a description of Endocyte's reported financial results.

        Although a summary of the Projections is presented with numerical specificity, the Projections reflect numerous variables, assumptions and estimates as to future events (including those related to industry performance and general business, economic, market and financial conditions and additional matters specific to Endocyte's business) that are inherently subjective and uncertain and are beyond the control of our management, but that our management believed were reasonable at the time the Projections were prepared, taking into account relevant information available to management at the time. In particular, although Endocyte has no active clinical trial in the pre-taxane setting for 177Lu-PSMA-617, management nevertheless ascribed net present value to this potential indication given

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the likelihood of commencing a Phase 3 clinical study with registrative intent. Given standard industry probabilities for pre-clinical/early stage programs, current values for those programs were determined by management to be negative or neutral.

        While the Projections were prepared in good faith, the information included in the Projections is not fact and should not be relied upon as necessarily indicative of actual future results, nor can any assurance be made regarding future events. Important factors that may affect actual results and cause the Projections not to be achieved include general economic, competitive, regulatory and financial market conditions; certain accounting assumptions; changes in actual or projected cash flows; competitive pressures; changes in tax law; as well as matters specific to Endocyte's business and the risks and uncertainties described under the section entitled "Cautionary Statement Concerning Forward-Looking Statements", all of which are difficult to predict and many of which are outside Endocyte's control. Endocyte's stockholders are urged to review Endocyte's SEC filings for a description of risk factors with respect to Endocyte's business. In addition, the Projections do not take into account any circumstances or events occurring after the date that they were prepared and do not give effect to the merger. As a result, there can be no assurance that the Projections will be realized, and actual results may be materially better or worse than those contained in the Projections. The inclusion of this information should not be regarded as an indication that Endocyte or any of its affiliates, officers, directors, advisors or other representatives, or any other recipient of this information considered, or now considers, the Projections to be material information of Endocyte or necessarily predictive of actual future results nor should it be construed as financial guidance, and it should not be relied upon as such.

        The summary of the Projections is not included in this proxy statement in order to induce any stockholder to vote in favor of the proposal to adopt the merger agreement or any of the other proposals to be voted on at the special meeting or to influence any stockholder to make any investment decision with respect to the merger, including whether or not to seek appraisal rights with respect to shares of our common stock. The summary of the Projections is included in this proxy statement only because such information was provided to the special committee and our board and Endocyte's financial advisors.

        The Projections should be evaluated, if at all, in conjunction with the historical financial statements and other information regarding Endocyte contained in our public filings with the SEC. The Projections were reviewed by Endocyte's management with, and considered by, the Endocyte special committee and board in connection with their evaluation and approval of the merger.

        The Projections are forward-looking statements. For information on factors that may cause Endocyte's future results to materially vary, see the section entitled "Cautionary Statement Concerning Forward-Looking Statements".

        Except to the extent required by applicable law, we do not intend, and expressly disclaim any responsibility, to update or otherwise revise or reconcile the Projections to reflect circumstances existing after the date when Endocyte prepared the Projections or to reflect the occurrence of future events or changes in general economic or industry conditions, even in the event that any of the assumptions underlying the Projections are shown not to be appropriate. Since the Projections cover multiple years, such information by its nature becomes less predictive with each successive year.

        In light of the foregoing factors and the uncertainties inherent in the Projections, our stockholders are cautioned not to place undue reliance on the Projections included in this proxy statement.

        Certain of the measures included in the Projections may be considered non-GAAP financial measures, as noted below. Non-GAAP financial measures should not be considered in isolation from, or as a substitute for or superior measure to, financial information presented in compliance with GAAP. Endocyte's stockholders should also note that these non-GAAP financial measures presented in

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this proxy statement have no standardized meaning prescribed by GAAP, and therefore have limits in their usefulness. Because of the non-standardized definitions, the non-GAAP financial measures as used by Endocyte in this proxy statement and the accompanying footnotes may be calculated differently from, and therefore may not be comparable to, similarly titled amounts used by other companies.

        Our management determined that it would be appropriate to risk adjust the Projections since the results of the Phase 3 VISION trial of 177Lu-PSMA-617 were unknown and the potential approval of 177Lu-PSMA-617 remained uncertain. As such, the following Projections reflect risk-adjustments made by our management based on industry oncology benchmarks and our management's experience:

 
  2018E   2019E   2020E   2021E   2022E   2023E   2024E   2025E   2026E   2027E   2028E   2029E   2030E   2031E   2032E   2033E   2034E   2035E  

Net Revenue

              $ 221   $ 432   $ 673   $ 844   $ 937   $ 1,030   $ 1,054   $ 1,056   $ 1,056   $ 1,082   $ 1,109   $ 1,143   $ 1,178   $ 1,025   $ 220  

Total Gross Profit(1)

          $ (3 ) $ 60   $ 257   $ 394   $ 493   $ 549   $ 606   $ 622   $ 626   $ 658   $ 677   $ 696   $ 720   $ 745   $ 665   $ 191  

Operating Income (after taxes)(2)

  $ (44 ) $ (105 ) $ (102 ) $ (1 ) $ 155   $ 250   $ 323   $ 363   $ 405   $ 415   $ 417   $ 439   $ 451   $ 464   $ 480   $ 497   $ 437   $ 107  

(Less): D in NWC

                (11 )   (9 )   (10 )   (6 )   (2 )   (2 )   (1 )   (0 )   (0 )   (1 )   (1 )   (2 )   (2 )   6     33  

(Less): Capital Expenditures

    (0 )   (0 )   (1 )   (0 )   (1 )   (0 )   (2 )   (0 )   (2 )   (0 )   (0 )   (0 )   (0 )   (0 )   (0 )   (0 )   (0 )   (0 )

Plus: D&A

    1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1     1  

Unlevered Free Cash Flow(3)

  $ (43 ) $ (104 ) $ (102 ) $ (11 ) $ 146 (4) $ 241 (4) $ 315   $ 362   $ 400   $ 415   $ 417   $ 440   $ 451   $ 463   $ 479   $ 496   $ 443   $ 140  

Note: Dollars in millions; figures may reflect rounding.

(1)
Total Gross Profit, as presented herein, reflects Net Revenue, less product cost of goods sold, less royalty payments, and less milestone payments.

(2)
Operating Income (after taxes), as presented herein, reflects Total Gross Profit, less tax expense (excluding the impact of net operating losses), less research and development expenses, less sales and marketing expenses, and less other selling, general and administrative expenses.

(3)
Unlevered Free Cash Flow, as presented herein, reflects Operating Income (after taxes), less increases (decreases) in net working capital, less capital expenditures, and plus depreciation and amortization.

(4)
Excludes impact of net operating losses; inclusive of the impact of net operating losses, unlevered free cash flow in 2022 and 2023 would be $200 and $309, respectively.

Opinion of Centerview Partners LLC

        Endocyte retained Centerview as a financial advisor to Endocyte, the special committee and our board in connection with the transactions contemplated by the merger agreement. In connection with this engagement, the special committee and our board requested that Centerview evaluate the fairness, from a financial point of view, to the holders of shares (other than (i) shares that are owned by Endocyte, Novartis, Merger Sub or any direct or indirect wholly owned subsidiary of Novartis and (ii) shares that are outstanding immediately prior to the effective time of the merger and that are held by any person who is entitled to demand and properly demands appraisal of such shares pursuant to, and who complies in all respects with, Section 262 of the DGCL (the shares referred to in clauses (i) and (ii), together with any shares held by any affiliate of Endocyte or Novartis are referred to in this section "—Opinion of Centerview Partners LLC," as "Excluded Shares")) of the merger consideration of $24.00 per share in cash, without interest, to be paid to such holders pursuant to the merger agreement. On October 17, 2018, Centerview rendered to the special committee and our board its oral opinion, which was subsequently confirmed by delivery of a written opinion dated October 17, 2018 that, as of such date and based upon and subject to the various assumptions made, procedures followed, matters considered, and qualifications and limitations upon the review undertaken by Centerview in preparing its opinion, the $24.00 per share merger consideration proposed to be paid to the holders of shares (other than Excluded Shares) pursuant to the merger agreement was fair, from a financial point of view, to such holders.

        The full text of Centerview's written opinion, dated October 17, 2018, which describes the various assumptions made, procedures followed, matters considered, and qualifications and limitations upon the

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review undertaken by Centerview in preparing its opinion, is attached as Annex C and is incorporated herein by reference. The summary of the written opinion of Centerview set forth below is qualified in its entirety to the full text of Centerview's written opinion attached as Annex C. Centerview's financial advisory services and opinion were provided for the information and assistance of the special committee and our board (in their capacity as directors and not in any other capacity) in connection with and for purposes of their consideration of the transactions contemplated by the merger agreement, and Centerview's opinion addressed only the fairness, from a financial point of view, as of the date thereof, to the holders of shares (other than Excluded Shares) of the $24.00 per share merger consideration to be paid to such holders pursuant to the merger agreement. Centerview's opinion did not address any other term or aspect of the merger agreement or the transactions contemplated thereby and does not constitute a recommendation to any stockholder of Endocyte or any other person as to how such stockholder or other person should vote with respect to the merger or otherwise act with respect to the transactions contemplated by the merger agreement or any other matter.

        The full text of Centerview's written opinion should be read carefully in its entirety for a description of the various assumptions made, procedures followed, matters considered, and qualifications and limitations upon the review undertaken by Centerview in preparing its opinion.

        In connection with rendering the opinion described above and performing its related financial analyses, Centerview reviewed, among other things:

        Centerview also participated in discussions with members of the senior management and representatives of Endocyte regarding their assessment of the Internal Data. In addition, Centerview reviewed publicly available financial and stock market data, including valuation multiples, for Endocyte and compared that data with similar data for certain other companies, the securities of which are publicly traded, in lines of business that Centerview deemed relevant. Centerview also compared certain of the proposed financial terms of the transactions contemplated by the merger agreement with the financial terms, to the extent publicly available, of certain other transactions that Centerview deemed relevant, and conducted such other financial studies and analyses and took into account such other information as Centerview deemed appropriate.

        Centerview assumed, without independent verification or any responsibility therefor, the accuracy and completeness of the financial, legal, regulatory, tax, accounting and other information supplied to, discussed with, or reviewed by Centerview for purposes of its opinion and, with Endocyte's consent, Centerview relied upon such information as being complete and accurate. In that regard, Centerview assumed, at Endocyte's direction, that the Internal Data (including, without limitation, the Projections) were reasonably prepared on bases reflecting the best currently available estimates and judgments of the management of Endocyte as to the matters covered thereby and Centerview relied, at Endocyte's direction, on the Internal Data for purposes of Centerview's analysis and opinion. Centerview expressed no view or opinion as to the Internal Data or the assumptions on which it was based. In addition, at

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Endocyte's direction, Centerview did not make any independent evaluation or appraisal of any of the assets or liabilities (contingent, derivative, off-balance-sheet or otherwise) of Endocyte, nor was Centerview furnished with any such evaluation or appraisal, and was not asked to conduct, and did not conduct, a physical inspection of the properties or assets of Endocyte. Centerview assumed, at Endocyte's direction, that the final executed merger agreement would not differ in any respect material to Centerview's analysis or opinion from the Draft Merger Agreement reviewed by Centerview. Centerview also assumed, at Endocyte's direction, that the transactions contemplated by the merger agreement will be consummated on the terms set forth in the merger agreement and in accordance with all applicable laws and other relevant documents or requirements, without delay or the waiver, modification or amendment of any term, condition or agreement, the effect of which would be material to Centerview's analysis or Centerview's opinion and that, in the course of obtaining the necessary governmental, regulatory and other approvals, consents, releases and waivers for the transactions contemplated by the merger agreement, no delay, limitation, restriction, condition or other change will be imposed, the effect of which would be material to Centerview's analysis or Centerview's opinion. Centerview did not evaluate and did not express any opinion as to the solvency or fair value of Endocyte, or the ability of Endocyte to pay its obligations when they come due, or as to the impact of the transactions contemplated by the merger agreement on such matters, under any state, federal or other laws relating to bankruptcy, insolvency or similar matters. Centerview is not a legal, regulatory, tax or accounting advisor, and Centerview expressed no opinion as to any legal, regulatory, tax or accounting matters.

        Centerview's opinion expressed no view as to, and did not address, Endocyte's underlying business decision to proceed with or effect the transactions contemplated by the merger agreement, or the relative merits of such transactions as compared to any alternative business strategies or transactions that might be available to Endocyte or in which Endocyte might engage. Centerview's opinion was limited to and addressed only the fairness, from a financial point of view, as of the date of Centerview's written opinion, to the holders of the shares (other than Excluded Shares) of the $24.00 per share merger consideration to be paid to such holders pursuant to the merger agreement. For purposes of its opinion, Centerview was not asked to, and Centerview did not, express any view on, and its opinion did not address, any other term or aspect of the merger agreement or the transactions contemplated thereby, including, without limitation, the structure or form of such transactions, or any other agreements or arrangements contemplated by the merger agreement or entered into in connection with or otherwise contemplated by such transactions, including, without limitation, the fairness of such transactions or any other term or aspect of such transactions to, or any consideration to be received in connection therewith by, or the impact of such transactions on, the holders of any other class of securities, creditors or other constituencies of Endocyte or any other party. In addition, Centerview expressed no view or opinion as to the fairness (financial or otherwise) of the amount, nature or any other aspect of any compensation to be paid or payable to any of the officers, directors or employees of Endocyte or any party, or class of such persons in connection with the transactions contemplated by the merger agreement, whether relative to the $24.00 per share merger consideration to be paid to the holders of shares of our common stock (other than Excluded Shares) pursuant to the merger agreement or otherwise. Centerview's opinion was necessarily based on financial, economic, monetary, currency, market and other conditions and circumstances as in effect on, and the information made available to Centerview as of, the date of Centerview's written opinion, and Centerview does not have any obligation or responsibility to update, revise or reaffirm its opinion based on circumstances, developments or events occurring after the date of Centerview's written opinion. Centerview's opinion does not constitute a recommendation to any stockholder of Endocyte or any other person as to how such stockholder or other person should vote with respect to the merger or otherwise act with respect to the transactions contemplated by the merger agreement or any other matter.

        Centerview's financial advisory services and its written opinion were provided for the information and assistance of the special committee and our board (in their capacity as directors and not in any

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other capacity) in connection with and for purposes of their consideration of the transactions contemplated by the merger agreement. The issuance of Centerview's opinion was approved by the Centerview Partners LLC Fairness Opinion Committee.

Summary of Centerview Financial Analysis

        The following is a summary of the material financial analyses prepared and reviewed with the special committee and our board in connection with Centerview's opinion, dated October 17, 2018. The summary set forth below does not purport to be a complete description of the financial analyses performed or factors considered by, and underlying the opinion of, Centerview, nor does the order of the financial analyses described represent the relative importance or weight given to those financial analyses by Centerview. Centerview may have deemed various assumptions more or less probable than other assumptions, so the reference ranges resulting from any particular portion of the analyses summarized below should not be taken to be Centerview's view of the actual value of Endocyte. Some of the summaries of the financial analyses set forth below include information presented in tabular format. In order to fully understand the financial analyses, the tables must be read together with the text of each summary, as the tables alone do not constitute a complete description of the financial analyses performed by Centerview. Considering the data in the tables below without considering all financial analyses or factors or the full narrative description of such analyses or factors, including the methodologies and assumptions underlying such analyses or factors, could create a misleading or incomplete view of the processes underlying Centerview's financial analyses and its opinion. In performing its analyses, Centerview made numerous assumptions with respect to industry performance, general business and economic conditions and other matters, many of which are beyond the control of Endocyte or any other parties to the transactions contemplated by the merger agreement. None of Endocyte, Novartis, Merger Sub or Centerview or any other person assumes responsibility if future results are materially different from those discussed. Any estimates contained in these analyses are not necessarily indicative of actual values or predictive of future results or values, which may be significantly more or less favorable than as set forth below. In addition, analyses relating to the value of Endocyte do not purport to be appraisals or reflect the prices at which Endocyte may actually be sold. Accordingly, the assumptions and estimates used in, and the results derived from, the financial analyses are inherently subject to substantial uncertainty. Except as otherwise noted, the following quantitative information, to the extent that it is based on market data, is based on market data as it existed on or before October 16, 2018 (the last trading day prior to the preparation of the financial analysis presented by Centerview at the October 17, 2018 meetings of the special committee and our board) and is not necessarily indicative of current market conditions.

Selected Public Company Analysis

        Centerview reviewed certain financial information of Endocyte and compared it to corresponding financial information of certain publicly traded companies that Centerview selected based on its experience and professional judgment (which are referred to as the "selected companies" in this summary of Centerview's opinion). Although none of the selected companies is directly comparable to Endocyte, the companies listed below were chosen by Centerview, among other reasons, because they are publicly traded biopharmaceutical companies with oncology-focused, clinical stage assets and certain operational, business and/or financial characteristics that, for the purposes of Centerview's analysis, may be considered similar to those of Endocyte.

        However, because none of the selected companies is exactly the same as Endocyte, Centerview believed that it was inappropriate to, and therefore did not, rely solely on the quantitative results of the selected public company analysis. Accordingly, Centerview also made qualitative judgments, based on its experience and professional judgment, concerning differences between the operational, business and/or financial characteristics of Endocyte and the selected companies, which could affect the public

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trading values of each, in order to provide a context in which to consider the results of the quantitative analysis.

        Using publicly available information obtained from SEC filings and other data sources as of October 16, 2018, Centerview calculated, financial multiples for each selected company. With respect to each of the selected companies, Centerview calculated the company's enterprise value (calculated as the equity value (determined using the treasury stock method and taking into account outstanding in-the-money options, warrants and restricted stock units) plus the book value of debt and certain liabilities less cash and cash equivalents), which is referred to, with respect to the selected companies, as "Enterprise Value", as a multiple of Wall Street research analyst consensus estimated revenues for calendar year 2023.

        The results of this analysis are summarized below:

Selected Companies
  Enterprise
Value / 2023E Revenue

Mirati Therapeutics, Inc. 

  2.5x

G1 Therapeutics, Inc. 

  3.3x

Iovance Biotherapeutics, Inc. 

  1.6x

Deciphera Pharmaceuticals, Inc. 

  2.0x

ImmunoGen, Inc. 

  1.2x

MacroGenics, Inc. 

  0.9x

Kura Oncology, Inc. 

  2.1x

TG Therapeutics, Inc. 

  0.9x

CytomX Therapeutics, Inc. 

  0.5x

High

 

3.3x

Median

  1.6x

Low

  0.5x

        Based on its analysis and other considerations that Centerview deemed relevant in its professional judgment and experience, Centerview applied a range of 1.0x to 2.0x multiples of estimated 2023 revenues derived from the selected companies, to Endocyte's estimated calendar year 2023 revenue of $673mm, based on the Projections, which resulted in a range of implied values per share of approximately $11.71 to $19.46. Centerview then compared this range to the $24.00 per share merger consideration proposed to be paid to the holders of shares of our common stock (other than Excluded Shares) pursuant to the merger agreement.

Discounted Cash Flow Analysis

        Centerview performed a discounted cash flow analysis of Endocyte based on the Projections and the calculations of risk adjusted, after-tax unlevered free cash flows set forth in "The Merger (Proposal 1)Certain Endocyte Unaudited Prospective Financial Information". A discounted cash flow analysis is a traditional valuation methodology used to derive a valuation of an asset or set of assets by calculating the "present value" of estimated future cash flows of the asset or set of assets. "Present value" refers to the current value of future cash flows and is obtained by discounting those future cash flows by a discount rate that takes into account macroeconomic assumptions and estimates of risk, the opportunity cost of capital, expected returns and other appropriate factors.

        In performing this analysis, Centerview calculated a range of equity values for Endocyte by (a) discounting to present value as of September 30, 2018 using discount rates ranging from 13.0% to 15.0% (reflecting Centerview's analysis of Endocyte's weighted average cost of capital) and the mid-year convention: (i) the forecasted risk adjusted, after-tax unlevered free cash flows of Endocyte over the period beginning on September 30, 2018 and ending on December 31, 2035 utilized by

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Centerview as set forth in "The Merger (Proposal 1)Certain Endocyte Unaudited Prospective Financial Information", (ii) an implied terminal value of Endocyte, calculated by Centerview applying a perpetuity growth rate of (80%) to Endocyte's after-tax unlevered free cash flows for the terminal year (as set forth in "The Merger (Proposal 1)Certain Endocyte Unaudited Prospective Financial Information") and (iii) net present value of tax savings from usage of net operating losses and future losses and (b) adding to the foregoing results Endocyte's net cash balance as of September 30, 2018, as set forth in the Internal Data. Centerview divided the result of the foregoing calculations by the number of fully-diluted outstanding shares (determined using the treasury stock method and taking into account outstanding in-the-money options, warrants and restricted stock units) as of October 16, 2018 based on the Internal Data to derive a range of implied values per share of approximately $17.63 to $20.20 per share. Centerview compared this range to the $24.00 per share merger consideration to be paid to the holders of shares of our common stock (other than Excluded Shares) pursuant to the merger agreement.

Other Factors

        Centerview noted for the special committee and our board certain additional factors solely for informational purposes, including, among other things, the following:

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        The selected transactions considered in this analysis are summarized below (dollars in millions):

 
   
   
  Premium  
Date Announced
  Target   Acquiror   1 Day   30 Day
VWAP
 
05/10/18   ARMO BioSciences, Inc.   Eli Lilly and Company     67.7 %   78.5 %
04/11/18   Wilson Therapeutics AB   Alexion Pharmaceuticals Inc.     70.3 %   59.9 %
04/09/18   AveXis, Inc.   Novartis AG     88.1 %   71.9 %
01/31/18   Cascadian Therapeutics, Inc.   Seattle Genetics, Inc.     69.5 %   138.6 %
01/22/18   Juno Therapeutics, Inc.   Celgene Corp.     90.8 %   78.6 %
01/05/18   TiGenix NV   Takeda Pharmaceutical Company Ltd.     50.3 %   73.7 %
12/22/17   Ignyta Inc.   Roche Holding AG     73.6 %   71.3 %
07/24/17   NeuroDerm Ltd.   Mitsubishi Tanabe Pharma Corporation     79.3 %   66.2 %
09/20/16   Tobira Therapeutics, Inc.   Allergan plc     517.6 %   525.3 %
09/14/16   Vitae Pharmaceuticals, Inc.   Allergan plc     159.3 %   157.2 %
01/19/16   Biotie Therapies Corp.   Acorda Therapeutics, Inc.     93.9 %   82.7 %
11/02/15   Dyax Corp.   Shire plc     35.5 %   51.2 %
07/14/15   Receptos, Inc.   Celgene Corp.     44.6 %   47.3 %
09/28/14   Ambit Biosciences Corporation   Daiichi Sankyo Company Limited     82.9 %   98.0 %
09/05/13   Astex Pharmaceuticals, Inc.   Otsuka Pharmaceutical Co., Ltd.     27.2 %   41.9 %
04/24/13   Prolor Biotech, Inc.   OPKO Health, Inc.     20.1 %   26.6 %

High

 

 

 

 

 

 

517.6

%

 

525.3

%
Median             72.0 %   72.8 %
Low             20.1 %   26.6 %

        Based on the analysis above and other considerations that Centerview deemed relevant in its experience and professional judgment, Centerview applied (i) a range of 30% to 80% to Endocyte's closing stock price on October 16, 2018 of $15.95, which resulted in an implied price range of approximately $20.74 to $28.71 per share and (ii) a range of 40% to 95% to Endocyte's 30-day VWAP on October 16, 2018 of $17.75, which resulted in an implied price range of approximately $24.84 to $34.60 per share.

General

        The preparation of a financial opinion is a complex analytical process involving various determinations as to the most appropriate and relevant methods of financial analysis and the application of those methods to the particular circumstances and, therefore, a financial opinion is not readily susceptible to summary description. In arriving at its opinion, Centerview did not draw, in isolation, conclusions from or with regard to any factor or analysis that it considered. Rather, Centerview made its determination as to fairness on the basis of its experience and professional judgment after considering the results of all of the analyses.

        Centerview's financial analyses and opinion were only one of many factors taken into consideration by the special committee and our board in their evaluation of the transactions contemplated by the merger agreement. Consequently, the analyses described above should not be viewed as determinative of the views of the special committee of our board, our board or management of Endocyte with respect to the $24.00 per share merger consideration to be paid to the holders of the shares of our common stock (other than Excluded Shares) pursuant to the merger agreement or as to whether the special

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committee and our board would have been willing to determine that a different consideration was fair. The consideration for the transactions contemplated by the merger agreement was determined through arm's-length negotiations between Endocyte and Novartis and was approved by the special committee and our board. Centerview provided advice to Endocyte during these negotiations. Centerview did not, however, recommend any specific amount of consideration to Endocyte, the special committee or our board, or that any specific amount of consideration constituted the only appropriate consideration for the transactions contemplated by the merger agreement.

        Centerview is a securities firm engaged directly and through affiliates and related persons in a number of investment banking, financial advisory and merchant banking activities. In the two years prior to the date of its written opinion, except for its involvement in the transactions contemplated by the merger agreement, Centerview was not engaged to provide financial advisory or other services to Endocyte, and Centerview did not receive any compensation from Endocyte. In the two years prior to the date of its written opinion, Centerview was engaged, and is currently engaged, to provide certain financial advisory services to Novartis unrelated to Endocyte and the transactions contemplated by the merger agreement, including in connection with Novartis's pending sale of its Sandoz division's U.S. dermatology and generic oral solids portfolios to Aurobindo Pharma U.S.A., Inc. Centerview has not received, but anticipates that in the future it will receive, compensation from Novartis ranging from approximately $15 million to $20 million for such services (contingent upon consummation of any transaction to which such services relate). Centerview may provide additional financial advisory and other services to or with respect to Endocyte or Novartis or their respective affiliates in the future, for which Centerview may receive compensation. Certain (i) of Centerview's and Centerview affiliates' directors, officers, members and employees, or family members of such persons, (ii) of Centerview's affiliates or related investment funds and (iii) investment funds or other persons in which any of the foregoing may have financial interests or with which they may co-invest, may at any time acquire, hold, sell or trade, in debt, equity and other securities or financial instruments (including derivatives, bank loans or other obligations) of, or investments in, Endocyte, Novartis or any of their respective affiliates, or any other party that may be involved in the transactions contemplated by the merger agreement.

        The special committee and our board selected Centerview as their financial advisor in connection with the transactions contemplated by the merger agreement based on Centerview's reputation and experience. Centerview is an internationally recognized investment banking firm that has substantial experience in transactions similar to the transactions contemplated by the merger agreement.

        In connection with Centerview's services as a financial advisor to the special committee and our board, Endocyte has agreed to pay Centerview an aggregate fee of approximately $33.6 million, $1.5 million of which was payable upon the rendering of Centerview's opinion and approximately $32.1 million of which is payable contingent upon consummation of the transactions contemplated by the merger agreement. In addition, Endocyte has agreed to reimburse certain of Centerview's expenses arising, and to indemnify Centerview against certain liabilities that may arise, out of Centerview's engagement.

Opinion of Jefferies LLC

        Endocyte has retained Jefferies as a financial advisor to Endocyte in connection with the merger. In connection with this engagement, Endocyte requested that Jefferies evaluate the fairness, from a financial point of view, of the $24.00 per share merger consideration to be received by holders of Endocyte common stock (other than, to the extent applicable, Novartis, Merger Sub and their respective affiliates) pursuant to the merger agreement. At a meeting of the board and the special committee held on October 17, 2018, Jefferies rendered an oral opinion, confirmed by delivery of a written opinion dated October 17, 2018, to the board and the special committee to the effect that, as of that date and based on and subject to the various assumptions made, procedures followed, matters considered and limitations and qualifications on the review undertaken as described in its opinion, the

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$24.00 per share merger consideration to be received by holders of Endocyte common stock (other than, to the extent applicable, Novartis, Merger Sub and their respective affiliates) pursuant to the merger agreement was fair, from a financial point of view, to such holders.

        The full text of Jefferies' opinion, which describes the various assumptions made, procedures followed, matters considered and limitations and qualifications on the review undertaken by Jefferies, is attached as Annex D to this proxy statement and is incorporated herein by reference. Jefferies' opinion was provided for the use and benefit of the board and the special committee (in their respective capacities as such) in their evaluation of the per share merger consideration from a financial point of view and did not address any other aspect of the merger or any other matter. The opinion did not address the relative merits of the merger as compared to any alternative transaction or opportunity that might be available to Endocyte, nor did it address the underlying business decision by Endocyte to engage in the merger. Jefferies' opinion does not constitute a recommendation as to how any securityholder should vote or act with respect to the merger or any other matter. The following summary is qualified in its entirety by reference to the full text of Jefferies' opinion.

        In arriving at its opinion, Jefferies, among other things:

reviewed a draft, dated October 17, 2018, of the merger agreement;

reviewed certain publicly available financial and other information regarding Endocyte;

reviewed certain information furnished to Jefferies by the management of Endocyte relating to the business, operations and prospects of Endocyte, including probability-weighted and tax-affected financial forecasts and estimates provided by the management of Endocyte;

held discussions with members of the senior management of Endocyte concerning the matters described in the second and third bullets immediately above;

reviewed the stock trading price history and implied trading multiples for Endocyte and compared them with those of certain publicly traded companies that Jefferies deemed relevant in evaluating Endocyte; and

conducted such other financial studies, analyses and investigations as Jefferies deemed appropriate.

        In its review and analysis and in rendering its opinion, Jefferies assumed and relied upon, but did not assume any responsibility to independently investigate or verify, the accuracy and completeness of all financial and other information that was supplied or otherwise made available by Endocyte or that was publicly available to Jefferies (including, without limitation, the information described above) or otherwise reviewed by Jefferies. Jefferies relied on assurances of the management and other representatives of Endocyte that they were not aware of any facts or circumstances that would make such information incomplete, inaccurate or misleading. In its review, Jefferies did not obtain an independent evaluation or appraisal of any of the assets or liabilities (contingent, derivative, off-balance sheet or otherwise), nor did Jefferies conduct a physical inspection of any of the properties or facilities, of Endocyte or any other entity and Jefferies was not furnished with, and assumed no responsibility to obtain, any such evaluations, appraisals or physical inspections.

        With respect to the financial forecasts and estimates (including as to potential net operating loss carryforwards of Endocyte on a standalone basis) provided to and reviewed by Jefferies, Jefferies noted that projecting future results of any company is inherently subject to uncertainty. However, Jefferies was advised, and Jefferies assumed, that the financial forecasts and estimates relating to Endocyte that Jefferies was directed to utilize for purposes of its analyses and opinion were reasonably prepared on bases reflecting the best currently available estimates and good faith judgments of the management of Endocyte as to the future financial performance of Endocyte and the other matters covered thereby. Jefferies expressed no opinion as to any financial forecasts or estimates or the assumptions on which they were based. Jefferies relied upon the assessments of the management of Endocyte as to, among

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other things, (i) the potential impact on Endocyte of market, competitive and other conditions, trends and developments in and prospects for, and governmental, regulatory and legislative matters relating to or affecting, the biopharmaceutical industry, and the oncology sector thereof, including with respect to third-party coverage and reimbursement for pharmaceutical products and the availability of raw materials used in such products, (ii) the product candidates, technology and intellectual property of Endocyte and associated regulatory approval processes and risks (including, without limitation, with respect to the research, development and commercialization of, and use and indications for, such product candidates, and the validity and duration of licenses and patents), and (iii) existing and future agreements and arrangements with, and the ability to attract, retain and/or replace, key employees, suppliers and manufacturers, and other commercial and collaboration relationships, of Endocyte. Jefferies assumed that there would not be any developments with respect to any such matters that would be meaningful in any respect to Jefferies' analyses or opinion.

        Jefferies' opinion was based on economic, monetary, regulatory, market and other conditions existing and which could be evaluated as of the date of Jefferies' opinion. Jefferies expressly disclaimed any undertaking or obligation to advise any person of any change in any fact or matter affecting its opinion of which Jefferies becomes aware after the date of its opinion. As Endocyte was aware, the credit, financial and stock markets, the industry in which Endocyte operates and the securities of Endocyte have experienced and continue to experience volatility and Jefferies expressed no view or opinion as to any potential effects of such volatility on Endocyte or the merger.

        Jefferies made no independent investigation of, and Jefferies expressed no view or opinion as to, any legal, regulatory, accounting or tax matters affecting or relating to Endocyte or the merger and Jefferies assumed the correctness in all respects meaningful to its analyses and opinion of all legal, regulatory, accounting and tax advice given to Endocyte, the board and/or the special committee, including, without limitation, with respect to changes in, and the impact of, tax or other laws, regulations and governmental and legislative policies affecting Endocyte or the merger and legal, regulatory, accounting and tax consequences to Endocyte or its securityholders of the terms of, and transactions contemplated by, the merger agreement and related documents. Jefferies assumed that the merger would be consummated in accordance with its terms without waiver, modification or amendment of any material term, condition or agreement and in compliance with all applicable laws, documents and other requirements and that, in the course of obtaining the necessary governmental, regulatory or third-party approvals, consents, waivers and releases for the merger, including with respect to any divestitures or other requirements, no delay, limitation, restriction or condition would be imposed or occur that would have an adverse effect on Endocyte or the merger or that otherwise would be meaningful in any respect to Jefferies' analyses or opinion. Jefferies also assumed that the final merger agreement, when signed by the parties thereto, would not differ from the draft reviewed by Jefferies in any respect meaningful to Jefferies' analyses or opinion.

        Jefferies' opinion was provided for the use and benefit of the board and the special committee (in their respective capacities as such) in their evaluation of the per share merger consideration from a financial point of view. Jefferies was not requested to, and Jefferies did not, participate in the negotiation or structuring of the merger nor was Jefferies requested to, and Jefferies did not, solicit third-party indications of interest in the acquisition of all or a part of Endocyte or any alternative transaction. Jefferies' opinion did not address the relative merits of the transactions contemplated by the merger agreement as compared to any alternative transaction or opportunity that might be available to Endocyte, nor did it address the underlying business decision by Endocyte to engage in the merger or the terms of the merger agreement or the documents referred to therein, including the form or structure of the merger or any term, aspect or implication of any agreements, arrangements or understandings entered into in connection with, or contemplated by or resulting from, the merger or otherwise. Jefferies' opinion was limited to the fairness, from a financial point of view, of the per share merger consideration to holders of Endocyte common stock (to the extent expressly specified in such

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opinion) without regard to individual circumstances of specific holders that may distinguish such holders or the securities of Endocyte held by such holders, and Jefferies was not asked to, and Jefferies' opinion did not, address the fairness, financial or otherwise, of any consideration to the holders of any class of securities, creditors or other constituencies of Endocyte or any other party. Jefferies expressed no view or opinion as to the prices at which shares of Endocyte common stock or any other securities of Endocyte may trade or otherwise be transferable at any time. Furthermore, Jefferies did not express any view or opinion as to the fairness, financial or otherwise, of the amount or nature of any compensation or other consideration payable to or to be received by any officers, directors or employees, or any class of such persons, in connection with the merger relative to the per share merger consideration or otherwise. The issuance of Jefferies' opinion was authorized by Jefferies' fairness committee.

        In connection with rendering its opinion to the board and the special committee, Jefferies performed a variety of financial and comparative analyses, including those described below. The following summary is not a complete description of all analyses performed and factors considered by Jefferies in connection with its opinion. The preparation of a financial opinion is a complex process involving subjective judgments and is not necessarily susceptible to partial analysis or summary description. With respect to the selected public companies analysis summarized below, no company used as a comparison was identical or directly comparable to Endocyte. These analyses necessarily involved complex considerations and judgments concerning financial and operating characteristics and other factors that could affect the public trading, acquisition or other values of the companies concerned.

        Jefferies believes that its analyses and the summary below must be considered as a whole and that selecting portions of its analyses and factors or focusing on information presented in tabular format, without considering all analyses and factors or the narrative description of the analyses, could create a misleading or incomplete view of the processes underlying Jefferies' analyses and opinion. Jefferies did not draw, in isolation, conclusions from or with regard to any one factor or method of analysis for purposes of its opinion, but rather arrived at its ultimate opinion based on the results of all analyses undertaken by it and assessed as a whole.

        The estimates of the future performance of Endocyte in or underlying Jefferies' analyses are not necessarily indicative of future results or values, which may be significantly more or less favorable than those estimates. In performing its analyses, Jefferies considered industry performance, general business and economic conditions and other matters, many of which were beyond the control of Endocyte. Estimates of the financial value of companies or businesses do not purport to be appraisals or necessarily reflect the prices at which companies, businesses or securities actually may be sold or acquired. Accordingly, the estimates used in, and the implied reference ranges resulting from, any particular analysis described below are inherently subject to substantial uncertainty and should not be taken as Jefferies' view of the actual value of Endocyte or its business or securities.

        The per share merger consideration was determined through negotiations between Endocyte and Novartis, and the decision by Endocyte to enter into the merger agreement was solely that of the board. Jefferies' opinion and financial analyses were only one of many factors considered by the board and the special committee in their evaluation of the per share merger consideration and should not be viewed as determinative of the views of the board, the special committee or Endocyte's management with respect to the merger or the consideration payable in the merger.

Financial Analyses

        The summary of the financial analyses described in this section entitled "—Financial Analyses" is a summary of the material financial analyses reviewed with the board and the special committee and performed by Jefferies in connection with its opinion. The financial analyses summarized below include

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information presented in tabular format. In order to fully understand Jefferies' financial analyses, the tables must be read together with the text of each summary. The tables alone do not constitute a complete description of the financial analyses. Considering the data below without considering the full narrative description of the financial analyses, including the methodologies and assumptions underlying the analyses, could create a misleading or incomplete view of Jefferies' financial analyses. For purposes of the financial analyses described below, the term "Endocyte forecasts" means the probability-weighted and tax-affected financial forecasts and estimates of Endocyte's management.

        Selected Public Companies Analysis.    Jefferies reviewed publicly available financial, stock market and operating information of Endocyte and the following ten selected U.S. publicly traded companies in the oncology sector of the biopharmaceutical industry that Jefferies considered generally relevant for purposes of analysis (which are referred to as the "selected companies" in this section):

Array BioPharma Inc.

Atara Biotherapeutics, Inc.

Blueprint Medicines Corporation

Clovis Oncology, Inc.

CytomX Therapeutics, Inc.

Deciphera Pharmaceuticals, Inc.

ImmunoGen, Inc.

Immunomedics, Inc.

Mirati Therapeutics, Inc.

Progenics Pharmaceuticals, Inc.

        Jefferies reviewed, among other information, enterprise values of the selected companies, calculated as fully diluted equity values based on closing stock prices on October 16, 2018 plus total debt and preferred equity (as applicable) less cash and cash equivalents and short-term investments, as a multiple of calendar year 2022 and calendar year 2023 estimated revenue. Financial data of the selected companies were based on publicly available research analysts' estimates, public filings and other publicly available information. Financial data of Endocyte was based on publicly available research analysts' estimates and the Endocyte forecasts.

        The overall low to high calendar year 2022 and calendar year 2023 estimated revenue multiples observed for the selected companies were 1.17x to 6.26x (with a median of 3.06x) and 0.64x to 4.19x (with a median of 2.00x), respectively. Jefferies then applied selected ranges derived from the selected companies of calendar year 2022 and calendar year 2023 estimated revenue multiples of 2.75x to 3.25x and 1.75x to 2.25x, respectively, to corresponding data of Endocyte based on the Endocyte forecasts. This analysis indicated the following approximate implied per share equity value reference ranges for Endocyte, as compared to the per share merger consideration:

Implied Per Share Equity Value Reference Ranges Based on:    
 
CY2022E Revenue   CY2023E Revenue   Per Share
Merger
Consideration
 
$17.60 - $20.03   $17.49 - $21.28   $ 24.00  

        Discounted Cash Flow Analysis.    Jefferies performed a discounted cash flow analysis of Endocyte by calculating the estimated present value of the standalone unlevered, after-tax free cash flows that Endocyte was forecasted to generate during the calendar years ending December 31, 2019 through December 31, 2035 based on the Endocyte forecasts (inclusive of Endocyte's net operating loss

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carryforwards). For purposes of this analysis, stock-based compensation was treated as a cash expense. The implied terminal value of Endocyte was derived by applying to Endocyte's unlevered after-tax free cash flow for the calendar year ending 2035 (normalized in the terminal year) a selected range of perpetuity growth rates of 0.0% to (10.0%). The present values (as of January 1, 2019) of the cash flows and terminal values were then calculated using a selected discount rate range of 13.2% to 14.2%. This analysis indicated the following approximate implied per share equity value reference range for Endocyte, as compared to the per share merger consideration:

Implied Per Share Equity Value Reference Range   Per Share
Merger
Consideration
$19.73 - $21.73   $24.00

Certain Additional Information

        Jefferies observed certain additional information that was not considered part of Jefferies' financial analysis with respect to its opinion but was noted for informational purposes, including the implied premiums paid or proposed to be paid in 24 selected mergers and acquisition transactions in the biopharmaceutical industry; applying a selected range of implied premiums of approximately 39.8% to 81.5% (reflecting the overall 25th and 75th percentile implied premiums derived from such transactions based on the closing stock prices of the target companies involved in such transactions one trading day prior to public announcement of such transactions or prior to market speculation of a potential acquisition of the target company, as applicable) to the closing price of Endocyte common stock on October 16, 2018 of $15.95 per share indicated an approximate implied equity value reference range for Endocyte of $22.30 to $28.95 per share.

Miscellaneous

        Endocyte agreed to pay Jefferies for its financial advisory services with respect to its opinion in connection with the merger a fee of $2 million, payable upon delivery of Jefferies' opinion to the board and the special committee. In addition, Endocyte agreed to reimburse Jefferies for expenses, including fees and expenses of counsel, incurred in connection with Jefferies' engagement and to indemnify Jefferies and related parties against liabilities, including liabilities under federal securities laws, arising out of or in connection with the services rendered and to be rendered by Jefferies under its engagement.

        As the board and the special committee were aware, Jefferies and its affiliates in the past provided and in the future may provide financial advisory and/or financing services to Endocyte and its affiliates unrelated to the merger, for which services Jefferies and its affiliates received and would expect to receive compensation, including, during the two-year period prior to the date of Jefferies' opinion, having acted as joint bookrunning manager for certain public offerings of Endocyte common stock, for which services Jefferies and its affiliates received an aggregate fee of approximately $7.5 million. As the board and the special committee also were aware, although Jefferies and its affiliates had not provided financial advisory or financing services to Novartis during the two-year period prior to the date of Jefferies' opinion for which Jefferies and its affiliates received compensation, Jefferies and its affiliates may provide such services to Novartis and/or its affiliates in the future, for which services Jefferies and its affiliates would expect to receive compensation. In addition, Jefferies maintains a market in the securities of Endocyte and, in the ordinary course of business, Jefferies and its affiliates may trade or hold securities of Endocyte, Novartis and their respective affiliates for Jefferies' own account and for the accounts of Jefferies' customers and, accordingly, may at any time hold long or short positions in those securities.

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        Jefferies was selected as Endocyte's financial advisor in connection with the merger because, among other things, Jefferies is an internationally recognized investment banking firm with substantial experience in merger and acquisition transactions and based on its familiarity with Endocyte and its business. Jefferies is regularly engaged in the valuation of businesses and their securities in connection with mergers and acquisitions, leveraged buyouts, negotiated underwritings, competitive bids, secondary distributions of listed and unlisted securities and private placements.

Financing of the Merger

        The merger is not conditioned on any financing arrangements or contingencies. We anticipate that the total amount of funds necessary to consummate the merger and the related transactions, including the funds needed to (i) pay our stockholders the amounts due to them under the merger agreement; (ii) make payments in respect of Endocyte's outstanding equity-based awards pursuant to the merger agreement; and (iii) pay all fees and expenses related to the merger will be funded through cash on hand available to Novartis.

Interests of Endocyte's Directors and Executive Officers in the Merger

        When considering the recommendation of our board that you vote for the proposal to adopt the merger agreement, you should be aware that our directors and executive officers may have interests in the merger that are different from, or in addition to, your interests as a stockholder. Our board was aware of these interests in approving the merger agreement and the merger and in recommending that the merger agreement be adopted by our stockholders.

Treatment of Director and Executive Officer Common Stock

        As is the case for our stockholders generally, our directors and executive officers will be entitled to receive $24.00 in cash, without interest, and subject to any applicable withholding taxes, for each share of our common stock that they own at the effective time. For information regarding beneficial ownership of our common stock by each of our current directors, our named executive officers and all directors and executive officers as a group, see the section entitled "Security Ownership of Certain Beneficial Owners and Management" beginning on page 102.

Treatment of Equity Awards

        Stock Options.    At the effective time of the merger, each option to purchase shares of our common stock that is outstanding and unexercised immediately prior to the effective time, whether vested or unvested, will (i) if the exercise price of such option is less than the merger consideration, be canceled, with the holder of such stock option becoming entitled to receive an amount in cash, without interest, equal to (a) the excess of the merger consideration over the exercise price of the option, multiplied by (b) the number of shares of our common stock subject to such option as of immediately prior to the effective time (subject to any applicable withholding taxes); or (ii) if the exercise price of such option is equal to or greater than the merger consideration, be canceled without any consideration being payable.

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        The following table sets forth, based on vested and unvested stock options outstanding as of October 29, 2018, the cash proceeds that each of our directors and executive officers would receive at the effective time of the merger in respect of such stock options based on the excess, if any, of the merger consideration of $24.00 over the applicable per share exercise price:

Name
  Number of
Stock Options
  Total Option
Consideration(1)
 

Executive Officers:

             

Michael A. Sherman

    951,071   $ 18,621,330  

Michael T. Andriole

    150,000   $ 3,227,500  

Alison A. Armour, M.D. 

    205,000   $ 4,197,750  

Christopher P. Leamon, Ph.D. 

    489,266   $ 8,921,151  

Katherine K. Parker

    166,500   $ 3,223,570  

Philip S. Low, Ph.D. 

    518,204   $ 9,501,688  

Erik C. Chelius

    124,893   $ 2,401,757  

Beth A. Taylor

    149,115   $ 2,821,881  

Non-Employee Directors:

             

John C. Aplin, Ph.D. 

    129,706   $ 2,180,033  

Colin Goddard

    108,000   $ 1,826,425  

Marc D. Kozin

    114,000   $ 1,925,425  

Patrick Machado

    42,000   $ 702,705  

Fred A. Middleton

    129,706   $ 2,180,033  

Lesley Russell, M.B., Ch.B. 

    122,000   $ 2,001,985  

Dawn Svoronos

    42,000   $ 553,980  

(1)
Amounts do not reflect withholding of applicable taxes.

        Restricted Stock Units.    At the effective time, each RSU that is outstanding and not settled immediately prior to the effective time, whether vested or unvested, will be canceled and converted into the right to receive an amount in cash, without interest, equal to the merger consideration multiplied by the number of shares of our common stock subject to such RSU as of immediately prior to the effective time (subject to any applicable withholding taxes).

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        The following table sets forth, based on RSUs outstanding as of October 29, 2018, the cash proceeds that each of our directors and executive officers would receive at the effective time of the merger in respect of such RSUs based on the merger consideration of $24.00 per share:

Name
  Number of
RSUs
  Total RSU
Consideration(1)
 

Executive Officers:

             

Michael A. Sherman

    135,626   $ 3,255,024  

Michael T. Andriole

    100,000   $ 2,400,000  

Alison A. Armour, M.D. 

    67,500   $ 1,620,000  

Christopher P. Leamon, Ph.D. 

    60,000   $ 1,440,000  

Katherine K. Parker

    40,000   $ 960,000  

Philip S. Low, Ph.D. 

    60,000   $ 1,440,000  

Erik C. Chelius

    34,047   $ 817,128  

Beth A. Taylor

    38,750   $ 930,000  

Non-Employee Directors:

             

John C. Aplin, Ph.D. 

    3,300   $ 79,200  

Colin Goddard

    3,300   $ 79,200  

Marc D. Kozin

    3,300   $ 79,200  

Patrick Machado

    5,800   $ 139,200  

Fred A. Middleton

    3,300   $ 79,200  

Lesley Russell, M.B., Ch.B. 

    3,300   $ 79,200  

Dawn Svoronos

    7,050   $ 169,200  

(1)
Amounts do not reflect withholding of applicable taxes.

Employee Stock Purchase Plan

        Three of our executive officers (Mr. Leamon, Dr. Low and Ms. Parker) are participants in the current offering period under the ESPP. The current offering period is scheduled to end on December 14, 2018 (the trading day immediately preceding the normal purchase date of December 15, 2018, which is not a trading day), at which time, assuming that the effective time of the merger has not yet occurred, shares of our common stock will be issued to the participants in the ESPP pursuant to the terms of the ESPP and such shares will be treated like all other outstanding shares of our common stock in the merger. In such case, the number of shares issued to each participant under the ESPP will be determined by dividing (i) the accumulated amount of payroll deductions that the participant has contributed to his or her ESPP account during the current offering period (the "ESPP Contributions") by (ii) 85% of the lower of (a) the closing price of a share of our common stock on the first day of the current offering period, which was $14.52, or (b) the closing price of a share of our common stock on December 14, 2018.

        In the event the effective time occurs on or prior to December 14, 2018, then each participant in the current offering period would be entitled to receive, reasonably promptly following the effective time, an amount in cash equal to the merger consideration of $24.00 per share of our common stock, multiplied by the result obtained by dividing (x) the ESPP Contributions as of the effective time by (y) 85% of the lower of (A) $14.52 or (B) the closing price of a share of our common stock on the date on which the effective time occurs.

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Payments Upon Termination or Change of Control Provisions

Change in Control and Severance Agreements

        We have entered into Change in Control and Severance Agreements with each of our executive officers, other than Dr. Low.

        The agreements provide that if the executive's employment is terminated by us without Cause (as defined below), or if he or she resigns for Good Reason (as defined below), prior to a Change in Control (as defined below) or after 12 months following a Change in Control, he or she will be entitled to:

        If the executive is terminated by the Company without Cause, or if he or she resigns for Good Reason, within 12 months following a Change in Control (a double trigger circumstance), he or she will be entitled to:

        The foregoing severance benefits will be subject to the executive providing us with an executed release of claims that becomes effective and irrevocable, and the executive's full compliance with the non-competition, non-interference, non- solicitation and non-disparagement provisions of the agreement and with the confidential information, non-disclosure and invention assignment agreements executed by the executive or the provisions of the agreement.

        Each agreement provides that during the period of the executive's employment with us and for two years after the termination of the executive's employment for any reason:

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        Each agreement provides that in the event the executive breaches any of the non-competition, non-interference, non-solicitation or non-disparagement provisions of the agreement, or any of the confidential information, non-disclosure or invention assignment agreements executed by the executive and/or any provisions of the agreement, the executive will forfeit his or her right to receive any severance payments or other benefits under the agreement and the executive will be obligated to pay to us an amount equal to the amount of any severance compensation received by the executive under the agreement, less $500.

        For the purposes of the agreements, "Cause," "Change in Control" and "Good Reason" are defined as follows:

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        In order for an event to qualify as Good Reason, the executive must not terminate employment with us without first providing us with written notice of the acts or omissions constituting the grounds for "Good Reason" within 90 days of the initial existence of the grounds for "Good Reason" and a reasonable cure period of not less than 30 days following the date of such notice.

        The Change in Control and Severance Agreements provide for a net-best arrangement relating to the "golden parachute" excise tax under Section 4999 of the Code. Pursuant to this provision, the amount of severance and any other merger-related payments and benefits that the executive officer otherwise would be entitled to receive will be reduced to the extent necessary to avoid the excise tax, but only if such reduction would result in the executive officer retaining a greater amount of such payments and benefits on an after-tax basis than had no reduction been made. The amounts set forth in the table below under "—Quantification of Payments and Benefits to Endocyte Named Executive Officers" does not take into account any such reduction.

Future Compensation Actions

        In connection with the merger agreement, Endocyte and Novartis agreed that, prior to the closing of the merger, they will consult and cooperate in good faith regarding actions intended to mitigate adverse consequences to our executives under Section 4999 of the Code, or to Endoctye under Section 280G of the Code, that could arise in connection with the merger. In addition, following the consultation and cooperation described in the preceding sentence, but prior to the closing of the merger, Endocyte may provide for reimbursement of excise taxes incurred, which excise tax reimbursement may not exceed $5.0 million in the aggregate for all of our executives. As of the date of this proxy statement, no mitigation strategies or actions have been agreed upon or taken. The amounts set forth in the table below under "—Quantification of Payments and Benefits to Endocyte Named Executive Officers" do not take into account any such mitigation actions or reimbursement arrangements.

        In addition, prior to the effective time, we are permitted to determine and pay cash bonus amounts to our employees, including executive officers, pursuant to our 2018 cash bonus program, as long as such determination is made in the ordinary course of business consistent with past practice. We estimate that the total amount of such cash bonus payouts will not exceed $3.6 million. The determination of such bonus payment amounts, and the payment of such bonuses, have not been made as of the date of this proxy statement, and the amounts set forth in the table below under

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"—Quantification of Payments and Benefits to Endocyte Named Executive Officers" do not take into account any such bonus payments.

Quantification of Payments and Benefits to Endocyte Named Executive Officers

        For purposes of this proxy statement, our named executive officers consist of (i) Michael A. Sherman, President and Chief Executive Officer; (ii) Michael T. Andriole, Chief Financial Officer; (iii) Alison A. Armour, M.D., Chief Medical Officer; (iv) Christopher P. Leamon, Ph.D., Vice President of Research; and (v) Katherine K. Parker, Vice President of Human Resources. The compensation that may be paid or become payable to our named executive officers in connection with the merger is subject to approval, on an advisory (non-binding) basis, by our stockholders, as described below in the section entitled "Advisory Vote on Named Executive Officer Merger-Related Compensation (Proposal 2)" on page 99.

        The table below and its footnotes show the estimated amounts of payments and benefits that each named executive officer would receive in connection with the merger, assuming that the merger was consummated and each such executive officer's employment was terminated by Endocyte without Cause or by the named executive officer with Good Reason (each of which we refer to as a "qualifying termination"), assuming the merger and a qualifying termination occur on October 29, 2018. The amounts reflected in the table and the footnotes are determined using a per-share price for our common stock of $24.00, as specified in the merger agreement.

        The calculations in the table below do not include amounts the named executive officers would have been entitled to receive regardless of whether the effective time has occurred, that were vested as of October 29, 2018, or amounts under contracts, agreements, plans or arrangements to the extent they do not discriminate in scope, terms or operation in favor of an officer and that are available generally to all of our salaried employees. The amounts in the table below also do not reflect the value arising from certain compensation actions that may occur before the closing of the merger, such as actions taken to mitigate or reimburse adverse tax consequences under Section 280G and Section 4999 of the Code or payment of annual bonus compensation for 2018, as described above under "—Payments Upon Termination or Change of Control ProvisionsFuture Compensation Actions."

        The estimated amounts below are based on multiple assumptions that may not actually occur, including assumptions described in this proxy statement. In addition, certain amounts will vary depending on the actual date of closing of the merger. As a result, the actual amounts, if any, to be received by an applicable individual may differ in material respects from the amounts set forth below.


Golden Parachute Compensation

Named Executive Officers
  Cash
Payment(1)
  Equity
Awards(2)
  Perquisites/
Benefits(3)
  Total  

Michael A. Sherman

  $ 1,548,800   $ 12,556,487   $ 44,351   $ 14,149,638  

Michael T. Andriole

  $ 735,420   $ 5,083,000   $ 50,324   $ 5,868,744  

Alison A. Armour, M.D. 

  $ 780,207   $ 4,126,950   $ 42,122   $ 4,949,279  

Christopher P. Leamon, Ph.D. 

  $ 735,204   $ 3,504,375   $ 38,851   $ 4,278,430  

Katherine K. Parker

  $ 369,222   $ 2,284,625   $ 40,610   $ 2,694,457  

(1)
The amounts shown in this column represent the aggregate cash severance that each named executive officer would receive upon a qualifying termination within 12 months following the effective time of the merger (double-trigger payments) and were determined based on the sum of (i) base salaries in effect on October 29, 2018 and represent an amount equal to the following percentage of the named executive officer's base salary: (a) for Mr. Sherman, 200%; (b) for Mr. Andriole and Drs. Armour and Leamon, 150%; and (c) for Ms. Parker, 100% and (ii) the

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    following percentage of the target bonus amount for 2018 for each named executive officer: (a) for Mr. Sherman, 200%; (b) for Mr. Andriole and Drs. Armour and Leamon, 150%; and (c) for Ms. Parker, 100%, as follows:

Named Executive Officers
  Cash Severance Payment   Cash Bonus Payment  

Michael A. Sherman

  $ 968,000   $ 580,800  

Michael T. Andriole

  $ 525,300   $ 210,120  

Alison A. Armour, M.D. 

  $ 557,291   $ 222,916  

Christopher P. Leamon, Ph.D. 

  $ 525,146   $ 210,058  

Katherine K. Parker

  $ 273,498   $ 95,724  
(2)
The amounts shown in this column represent the aggregate merger consideration that each named executive officer would receive with respect to unvested stock options and RSUs, all of which will vest and be paid in connection with the merger (single-trigger payments), as described in the section entitled "The Merger Agreement—Treatment of Equity Awards." These amounts are determined as of October 29, 2018.
Named Executive Officers
  Stock Options   RSUs   Total  

Michael A. Sherman

  $ 9,301,463   $ 3,255,024   $ 12,556,487  

Michael T. Andriole

  $ 2,683,000   $ 2,400,000   $ 5,083,000  

Alison A. Armour, M.D. 

  $ 2,506,950   $ 1,620,000   $ 4,126,950  

Christopher P. Leamon, Ph.D. 

  $ 2,064,375   $ 1,440,000   $ 3,504,375  

Katherine K. Parker

  $ 1,324,625   $ 960,000   $ 2,284,625  
(3)
The amounts shown in this column represent a payment amount equal to 140% of the COBRA continuation coverage amount for continued coverage under our medical, dental and vision plans for the named executive officer and his or her eligible dependents that would be paid upon a qualifying termination within 12 months following the effective time of the merger (double-trigger payments) for the following period: (i) for Mr. Sherman, 24 months; (ii) for Mr. Andriole and Drs. Armour and Leamon, 18 months; and (iii) for Ms. Parker, 12 months.

Certain Arrangements with Novartis

        Over the past three years, Philip S. Low, Ph.D., our Chief Science Officer and an Endocyte director, has had limited interactions with Novartis relating to scientific and therapeutic matters that are wholly unrelated to the merger. Such interactions included Dr. Low meeting with Novartis personnel on six occasions to discuss specific aspects of Dr. Low's work, as well as one speaking engagement by Dr. Low at a conference jointly sponsored by Novartis and the Juvenile Diabetes Research Institute. In connection with the meetings, Dr. Low received fees of approximately $5,000 in the aggregate and was reimbursed for his travel expenses for some of those meetings. Each of Dr. Low and Novartis agreed not to disclose any confidential information to the other in connection with those meetings.

Indemnification of and Insurance for Directors and Executive Officers

        Under the merger agreement, Novartis has agreed to cause the surviving corporation to assume the obligations with respect to all rights to indemnification, advancement of expenses and exculpation from liabilities, for acts or omissions occurring at or prior to the effective time existing in favor of our current or former directors or officers as provided in our certificate of incorporation, our bylaws or any indemnification agreement between such indemnified person and us, without further action, as of the effective time. Such obligations will survive the merger, will continue in full force and effect in accordance with their terms and will not be impaired by any modification of such terms in any amendment or restatement of our certificate of incorporation or bylaws following the effective time.

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        Novartis has also agreed to obtain, or cause the surviving corporation to obtain, at or prior to the effective time, a prepaid (or "tail") directors' and officers' liability insurance policy in respect of acts or omissions occurring at or prior to the effective time, covering each person currently covered by our directors' and officers' liability insurance policies, with coverage for six years following the effective time, on terms with respect to such coverage and amounts no less favorable to the insureds than those of such policy in effect on the date of the merger agreement, up to coverage for an annual premium that does not exceed 300% of the most recent annual premium paid by us for such insurance for our current fiscal year.

        Novartis and the surviving corporation are required to make proper provision for the continuation of these rights in connection with certain future corporate transactions.

Material U.S. Federal Income Tax Consequences of the Merger

        The following is a general discussion of the material U.S. federal income tax consequences of the merger to U.S. holders (as defined below) of our common stock whose shares are exchanged for cash pursuant to the merger. This discussion does not address U.S. federal income tax consequences with respect to holders other than U.S. holders. This discussion is based on the provisions of the U.S. Internal Revenue Code of 1986, as amended (the "Code"), applicable U.S. Treasury Regulations, judicial opinions and administrative rulings and published positions of the Internal Revenue Service (the "IRS"), each as in effect as of the date hereof. These authorities are subject to change or differing interpretations, possibly on a retroactive basis, and any such change or interpretation could affect the accuracy of the statements and conclusions set forth in this discussion. This discussion is for general information purposes only and does not purport to be a complete analysis of all potential tax consequences. This discussion does not address any tax consequences arising under the unearned income Medicare contribution tax pursuant to the Health Care and Education Reconciliation Act of 2010, nor does it address any tax considerations under state, local or foreign laws or U.S. federal laws other than those pertaining to the U.S. federal income tax. This discussion is not binding on the IRS or the courts and, therefore, could be subject to challenge, which could be sustained. No ruling will be sought from the IRS with respect to the merger.

        For purposes of this discussion, the term "U.S. holder" means a beneficial owner of our common stock that is for U.S. federal income tax purposes:

        This discussion applies only to U.S. holders of shares of our common stock who hold such shares as a capital asset within the meaning of Section 1221 of the Code (generally, property held for investment). Further, this discussion does not purport to consider all aspects of U.S. federal income taxation that may be relevant to a U.S. holder in light of its particular circumstances, or that may apply to U.S. holders subject to special treatment under U.S. federal income tax laws (including, for example, insurance companies, dealers or brokers in securities or foreign currencies, traders in securities who elect the mark-to-market method of accounting, holders subject to the alternative minimum tax, U.S. holders that have a functional currency other than the U.S. dollar, tax-exempt organizations,

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tax-qualified retirement plans, banks and other financial institutions, mutual funds, certain expatriates, S corporations, or other pass-through entities, or investors in such S corporations or other pass-through entities, real estate investment trusts, regulated investment companies, U.S. holders who hold shares of our common stock as part of a hedge, straddle, constructive sale, conversion or other integrated transaction, U.S. holders who will hold (actually or constructively) an equity interest in Novartis immediately after the merger, and U.S. holders who acquired their shares of our common stock through the exercise of employee stock options or other compensation arrangements).

        If a partnership (including for this purpose any entity or arrangement treated as a partnership for U.S. federal income tax purposes) holds shares of our common stock, the tax treatment of a partner in such partnership will generally depend on the status of the partners and the activities of the partnership. If you are, for U.S. federal income tax purposes, a partner in a partnership holding shares of our common stock, you should consult your tax advisor.

        This summary of U.S. federal income tax consequences is for general information purposes only and is not tax advice. Holders of our common stock are urged to consult their own tax advisors to determine the particular tax consequences to them of the merger, including the applicability and effect of the alternative minimum tax, the unearned income Medicare contribution tax and any other U.S. federal, or state, local, foreign or other tax laws.

        The receipt of cash by U.S. holders in exchange for shares of our common stock pursuant to the merger will be a taxable transaction for U.S. federal income tax purposes. In general, for U.S. federal income tax purposes, a U.S. holder who receives cash in exchange for shares of our common stock pursuant to the merger will recognize capital gain or loss in an amount equal to the difference, if any, between (1) the amount of cash received and (2) the U.S. holder's adjusted tax basis in such shares.

        Any such gain or loss will be long-term capital gain or loss if a U.S. holder's holding period in the shares of our common stock surrendered in the merger is greater than one year as of the date of the merger. Long-term capital gains of certain non-corporate holders, including individuals, are generally subject to U.S. federal income tax at preferential rates. The deductibility of capital losses is subject to limitations. If a U.S. holder acquired different blocks of our common stock at different times and different prices, such U.S. holder must determine its adjusted tax basis, gain or loss and holding period separately with respect to each block of our common stock.

        Payments made in exchange for shares of our common stock pursuant to the merger may be subject, under certain circumstances, to information reporting and backup withholding (currently at a rate of 24%). To avoid backup withholding, a U.S. holder that does not otherwise establish an exemption should complete and return to the applicable withholding agent a properly completed and executed IRS Form W-9, certifying that such U.S. holder is a U.S. person, that the taxpayer identification number provided is correct, and that such U.S. holder is not subject to backup withholding.

        Backup withholding is not an additional tax. Any amounts withheld under the backup withholding rules may be refunded or credited against a holder's U.S. federal income tax liability, if any, provided that such holder furnishes the required information to the IRS in a timely manner.

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Regulatory Approvals

        HSR Waiting Period.    Under the HSR Act and the rules promulgated thereunder, certain transactions, including the merger, may not be completed until notifications have been given and information furnished to the Antitrust Division and the FTC and all statutory waiting period requirements have been satisfied. Completion of the merger is subject to the expiration or termination of the applicable waiting period under the HSR Act.

        Under the HSR Act, the merger may not be completed until the expiration of a 30 calendar day waiting period, which begins when Novartis and Endocyte file Premerger Notification and Report Forms under the HSR Act with the FTC and the Antitrust Division, unless such waiting period is earlier terminated by the FTC and the Antitrust Division. Novartis and Endocyte will file their Premerger Notification and Report Forms on or before October 31, 2018 in connection with the merger, and the waiting period is expected to expire 30 calendar days after such filings. If prior to the expiration or termination of the waiting period either the FTC or the Antitrust Division issues a request for additional information or documentary material from Novartis or Endocyte (commonly called a second request), the waiting period with respect to the merger would be extended until the 30th calendar day following the date of Novartis' and Endocyte's substantial compliance with that request. After that time, absent Novartis' and Endocyte's agreement, the acquisition can be blocked only by court order. The FTC and the Antitrust Division may terminate the applicable waiting period at any time before its expiration.

        Committee on Foreign Investment in the United States Review.    The merger will be reviewed by the Committee on Foreign Investment in the United States. Under the rules governing the CFIUS process, the President of the United States, on the recommendation of CFIUS, may prohibit or suspend certain transactions, including the merger, of persons engaged in interstate commerce in the United States by foreign persons. This prohibition or suspension may occur if the President of the United States finds that there is credible evidence that leads the President of the United States to believe that the proposed transaction might threaten to impair the national security of the United States, and that applicable laws do not provide adequate authority to protect the national security of the United States. Alternatively, CFIUS may resolve any concerns about a transaction's potential impact by agreeing to mitigation measures with the parties prior to clearing the transaction.

        Endocyte, Novartis and Merger Sub intend to file jointly a required declaration with CFIUS on or before November 13, 2018. Following acceptance of the required declaration for review by CFIUS, a 30 calendar day declaration review period will begin. At or prior to the expiration of this declaration review period, CFIUS may conclude all action under Section 721, inform the parties that CFIUS is unable to complete action under Section 721, request a joint voluntary notice pursuant to 31 C.F.R. Part 801.501 or unilaterally initiate a review of the merger pursuant to 31 C.F.R. Part 801.504. If CFIUS does not conclude all action during the 30 calendar day declaration review period and requests a joint voluntary notice (or unilaterally initiates a review of the merger), CFIUS will have up to 105 additional calendar days to review and investigate the merger. At any time during either the review or investigation period, CFIUS can conclude all action by determining that there are no unresolved national security concerns. If CFIUS is unable to reach a conclusion regarding what to recommend or otherwise believes that the President of the United States should make the determination, CFIUS must submit a report to the President of the United States requesting the President of the United States to make the determination regarding disposition of the merger. After receiving the report from CFIUS, the President of the United States would have 15 calendar days to determine whether to take action regarding the merger, including its suspension or prohibition. At any time during this process, Endocyte, Novartis and Merger Sub may voluntarily withdraw and refile the joint voluntary notice to permit additional time to address concerns raised by CFIUS. Although neither Endocyte nor Novartis believes that the President of the United States will prohibit or suspend the merger, there can be no assurance on this.

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        Other Required Regulatory Approvals.    Completion of the merger is also subject to the receipt of certain antitrust or competition approvals of other jurisdictions if such approvals are required to complete the merger. Novartis and Endocyte are not presently aware of any such applicable approvals that are required under antitrust or other competition laws of other jurisdictions that would require Novartis and Endocyte to make any filings thereunder in order to complete the merger.

        In connection with the merger, Endocyte may seek to obtain consents of, and provide notices to, governmental agencies that have issued licenses or certificates or granted applications to Endocyte.

        At any time (regardless of whether before or after the expiration or termination of the statutory waiting periods under the HSR Act, or before or after the effective time), the Antitrust Division or the FTC, or foreign governmental authorities, may take action under applicable antitrust laws, including seeking to enjoin the completion of the merger, to rescind the merger or to conditionally permit completion of the merger subject to regulatory conditions or other remedies. In addition, U.S. state attorneys general could take action under applicable antitrust laws as they deem necessary or desirable in the public interest, including, without limitation, seeking to enjoin the completion of the merger or permitting completion subject to regulatory conditions. Private parties may also seek to take legal action under applicable antitrust laws to challenge the merger under some circumstances. Although neither Endocyte nor Novartis believes that the merger will violate the antitrust laws, there can be no assurance that a challenge to the merger on antitrust grounds will not be made or, if such a challenge is made, that it would not be successful.

Exclusive Forum Bylaw

        On October 17, 2018, our board of directors approved an amendment to our amended and restated bylaws, effective as of such date, in order to add an exclusive forum provision for the adjudication of certain disputes. The amendment, set forth in a new Article XI of the bylaws, provides that, unless Endocyte consents in writing to the selection of an alternative forum, the Court of Chancery of the State of Delaware (or, if the Court of Chancery lacks subject matter jurisdiction, any state court located within the State of Delaware or, if all such state courts lack subject matter jurisdiction, the federal district court for the District of Delaware) will be the sole and exclusive forum for (i) any derivative action or proceeding brought on behalf of Endocyte, (ii) any action or proceeding asserting a claim of breach of a fiduciary duty owed by any director, officer or other employee of Endocyte to Endocyte or its stockholders, (iii) any action or proceeding asserting a claim arising pursuant to, or seeking to enforce any right, obligation or remedy under, any provision of the laws of the State of Delaware (including the DGCL), Endocyte's amended and restated certificate of incorporation or the bylaws (as each may be amended from time to time), (iv) any action or proceeding as to which the DGCL confers jurisdiction on the Court of Chancery of the State of Delaware or (v) any action or proceeding asserting a claim governed by the internal affairs doctrine.

Delisting and Deregistration of Endocyte Common Stock

        If the merger is completed, our common stock will be delisted from the Nasdaq Global Market and deregistered under the Exchange Act.

The Merger Agreement Proposal

        We are asking you to approve a proposal to adopt the merger agreement. For a detailed discussion of the terms and conditions of the merger agreement, see the section entitled "The Merger Agreement." A copy of the merger agreement is attached to this proxy statement as Annex A.

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Vote Required and Board Recommendation

        Under Delaware law, approval of the proposal to adopt the merger agreement requires the affirmative vote of the holders of a majority of the outstanding shares of our common stock entitled to vote thereon. Abstentions and broker non-votes, if any, will have the same effect as a vote "AGAINST" the proposal.

        After considering various factors described in the section entitled "The Merger (Proposal 1)—Reasons for the Recommendation of the Special Committee and our Board," our board (upon the unanimous affirmative recommendation of the special committee of our board) determined that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and our stockholders and recommended that Endocyte stockholders vote in favor of the proposal to adopt the merger agreement. Accordingly, our board unanimously recommends that you vote "FOR" the proposal to adopt the merger agreement.

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THE MERGER AGREEMENT

        The following is a summary of the material provisions of the merger agreement, a copy of which is attached to this proxy statement as Annex A and which is incorporated by reference into this proxy statement. This summary does not purport to be complete and may not contain all of the information about the merger agreement that is important to you. We encourage you to read carefully the merger agreement in its entirety, as the rights and obligations of the parties thereto are governed by the express terms of the merger agreement and not by this summary or any other information contained in this proxy statement.

Explanatory Note Regarding the Merger Agreement

        The following summary of the merger agreement, and the copy of the merger agreement attached as Annex A to this proxy statement, are intended to provide information regarding the terms of the merger agreement and are not intended to provide any factual information about Endocyte or modify or supplement any factual disclosures about Endocyte in its public reports filed with the SEC. In particular, the merger agreement and the related summary are not intended to be, and should not be relied upon as, disclosures regarding any facts and circumstances relating to Endocyte. The merger agreement contains representations and warranties by and covenants of Endocyte, Novartis and Merger Sub that were made only for purposes of that agreement and as of specified dates. The representations, warranties and covenants in the merger agreement were made solely for the benefit of the parties to the merger agreement, may be subject to limitations agreed upon by the contracting parties, including being qualified by confidential disclosures and being made for the purposes of allocating contractual risk between the parties to the merger agreement instead of establishing these matters as facts, and may be subject to contractual standards of materiality or material adverse effect applicable to the contracting parties that generally differ from those applicable to investors. In addition, information concerning the subject matter of the representations, warranties and covenants may change after the date of the merger agreement, which subsequent information may or may not be fully reflected in Endocyte's public disclosures. The representations, warranties and covenants in the merger agreement and any descriptions thereof should be read in conjunction with the disclosures in Endocyte's periodic and current reports, proxy statements and other documents filed with the SEC. See the section entitled "Where You Can Find Additional Information." Moreover, the description of the merger agreement below does not purport to describe all of the terms of such agreement and is qualified in its entirety by reference to the full text of such agreement, a copy of which is attached hereto as Annex A and is incorporated herein by reference.

        Additional information about Endocyte may be found elsewhere in this proxy statement and Endocyte's other public filings. See the section entitled "Where You Can Find Additional Information."

Structure of the Merger; Certificate of Incorporation; Bylaws; Directors and Officers

        At the effective time, Merger Sub will merge with and into Endocyte, and the separate corporate existence of Merger Sub will cease. Endocyte will be the surviving corporation in the merger and will continue its corporate existence as a Delaware corporation and a wholly owned subsidiary of Novartis.

        At the effective time, the certificate of incorporation of the surviving corporation will be amended and restated in its entirety to be identical to the certificate of incorporation of Merger Sub as in effect immediately prior to the effective time (except that references to the name of Merger Sub will be replaced by references to Endocyte, Inc.), until thereafter amended in accordance with applicable law and the applicable provisions therein. Also at the effective time, the bylaws of the surviving corporation will be amended and restated in their entirety to be identical to the bylaws of Merger Sub as in effect immediately prior to the effective time (except that references to the name of Merger Sub will be replaced by references to Endocyte, Inc.), until thereafter amended in accordance with applicable law and the applicable provisions therein.

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        At the effective time, the individuals holding positions as directors of Merger Sub immediately before the effective time will become the initial directors of the surviving corporation, and the individuals holding positions as officers of Endocyte immediately before the effective time will be the initial officers of the surviving corporation, in each case until the earlier of their resignation or removal or until their respective successors are duly elected or appointed and qualified, as the case may be.

When the Merger Becomes Effective

        The closing of the merger will take place at 10:00 a.m. (New York City time) at the offices of Cravath, 825 Eighth Avenue, New York, New York 10019, no later than the third business day after the satisfaction (or, to the extent permitted by law, waiver by the party entitled thereto) of the conditions set forth in the merger agreement (other than those conditions that by their nature are to be satisfied at the closing, but subject to the satisfaction (or, to the extent permitted by law, waiver by the party entitled thereto) of such conditions), or at such other place, time and date as is agreed in writing by Novartis, Merger Sub and Endocyte.

        On the closing date, Novartis, Merger Sub and Endocyte will cause a certificate of merger to be filed with the Secretary of State of the State of Delaware. The merger will become effective at the time the certificate of merger is duly filed with the Secretary of State of the State of Delaware or at such other time as Novartis and Endocyte agree and specify in the certificate of merger.

        As of the date of the filing of this proxy statement, the parties expect to complete the merger in the first half of 2019. However, completion of the merger is subject to the satisfaction or waiver of the conditions to the completion of the merger, and factors outside the control of Endocyte or Novartis may delay the completion of the merger, or prevent it from being completed at all. There can be no assurances as to whether or when the merger will be completed, or that it will be completed as currently proposed, or at any particular time.

Effect of the Merger on our Common Stock

        At the effective time, each issued and outstanding share of our common stock (other than shares of our common stock owned by Endocyte, Novartis or Merger Sub immediately prior to the effective time ("excluded shares") and any shares of our common stock held by any Endocyte stockholder who properly demands and perfects appraisal rights under, and complies in all respects with, Section 262 of the DGCL, and has not validly withdrawn, waived or lost such rights ("appraisal shares")), will be converted automatically into the right to receive the merger consideration. The merger consideration will be $24.00 per share in cash, without interest and less any applicable withholding taxes.

        At the effective time, each excluded share will be automatically canceled and retired and will cease to exist, and no consideration will be delivered in exchange therefor.

        Shares of our common stock that are outstanding immediately prior to the effective time and that are held by any person who is entitled to demand and properly demands appraisal of such shares pursuant to, and who complies in all respects with, Section 262 of the DGCL, will not be converted into the right to receive the merger consideration, but instead, at the effective time, by virtue of the merger and without any action on the part of the holder thereof, will be canceled and retired and will cease to exist and will represent the right to receive only those rights provided under Section 262. If any such holder fails to perfect or otherwise waives, withdraws or loses the right to appraisal under Section 262 or a court of competent jurisdiction determines that such holder is not entitled to the relief provided by Section 262, then the rights of such holder pursuant to Section 262 will cease and such appraisal shares will be deemed to have been converted as of the effective time into, and will represent only the right to receive, the merger consideration. Endocyte has agreed to serve prompt notice to Novartis of any demands received by Endocyte for appraisal of any shares of our common stock, any withdrawals of any such demands or any other instruments received by Endocyte relating to the rights

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of appraisal of the holders of shares of our common stock, and Novartis will have the right to participate in and direct all negotiations and proceedings with respect to such demands. Endocyte has agreed that, prior to the effective time, it will not make any payment with respect to, or settle or offer to settle, or otherwise negotiate any such demands, or agree to do any of the foregoing, without the prior written consent of Novartis.

        At the effective time, each outstanding share of capital stock of Merger Sub will be converted into and become one validly issued, fully paid and nonassessable share of common stock of the surviving corporation.

Treatment of Endocyte Equity Awards; Employee Stock Purchase Plan

        Stock Options.    At the effective time, each stock option that is outstanding and unexercised immediately prior to the effective time, whether vested or unvested, will (i) if the exercise price of such stock option is less than the merger consideration, be canceled, with the holder of such stock option becoming entitled to receive an amount in cash, without interest, equal to (a) the excess of the merger consideration over the exercise price of the stock option, multiplied by (b) the number of shares of our common stock subject to such stock option as of immediately prior to the effective time (subject to any applicable withholding taxes); or (ii) if the exercise price of such stock option is equal to or greater than the merger consideration, be canceled without any consideration being payable.

        Restricted Stock Units.    At the effective time, each RSU that is outstanding and not settled immediately prior to the effective time, whether vested or unvested, will be canceled and converted into the right to receive an amount in cash, without interest, equal to the merger consideration multiplied by the number of shares of our common stock subject to such RSU as of immediately prior to the effective time (subject to any applicable withholding taxes).

        2010 Employee Stock Purchase Plan.    If the effective time occurs on or before the end of the ESPP current offering period, then reasonably promptly following the effective time (but in any event not later than three business days thereafter), the surviving corporation will pay, through the surviving corporation's payroll, to each participant in the current offering period an amount in cash equal to (i) the merger consideration multiplied by (ii) the result obtained by dividing (A) the amount of the payroll deductions credited to such participant's account pursuant to the ESPP as of the effective time by (B) the purchase price (as defined in the ESPP, with the last day of the applicable purchase period being deemed to be the date on which the effective time occurs), net of any applicable taxes withheld. If the effective time occurs after the last day of the current offering period, we will issue shares of our common stock to participants in the ESPP pursuant to the terms of the ESPP for the current offering period and such shares will be treated like all other outstanding common stock in the merger. In addition, we have agreed that, during the term of the merger agreement, we will not permit any further offering periods to commence under the ESPP, and we will not allow participants in the ESPP to increase their payroll deductions from those in effect on the date of the merger agreement or allow anyone who is not a participant in the ESPP as of the date of the merger agreement to become a participant. We will terminate the ESPP effective as of the effective time, and if the effective time has not occurred by the end of the current offering period, then we will suspend the ESPP until the effective time.

Treatment of Outstanding Warrant

        There is an outstanding warrant to purchase 442,000 shares of our common stock at an exercise price of $1.39, held by Cambridge Isotope Laboratories, Inc. Pursuant to the terms of the merger agreement and the warrant, the warrant will be automatically exercised immediately prior to the effective time, and the holder of the warrant will participate in the merger as a holder of our common stock on the same terms as other holders of our common stock, but the holder's aggregate

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consideration received in the merger will be reduced by the aggregate exercise price then in effect for the shares purchasable under the warrant.

Payment for Common Stock in the Merger

        At or immediately after the effective time, Novartis will take all steps necessary to enable and will cause the surviving corporation to provide to a bank or trust company reasonably acceptable to Endocyte (the "paying agent"), cash necessary to pay for the shares of our common stock converted into the right to receive the merger consideration pursuant to the merger agreement (such cash, the "exchange fund"). Promptly, and in any event no later than five business days after the effective time, the paying agent will mail to each holder of record of a certificate or book-entry share that immediately prior to the effective time represents outstanding shares of our common stock whose shares were converted into the right to receive the merger consideration (1) a letter of transmittal and (2) instructions for effecting the surrender of certificates or book-entry shares formerly representing shares of our common stock in exchange for the merger consideration. Upon (1) in the case of certificates, surrender of such certificates (or if lost, stolen or destroyed, the making of an affidavit and, if required, the posting of a bond) together with a duly executed letter of transmittal to the paying agent, or (2) in the case of book-entry shares, receipt of an "agent's message" by the paying agent, and delivery to the paying agent of such other documents as may reasonably be required by the paying agent, the holder of such certificates or book-entry shares, as applicable, will be entitled to receive the merger consideration in exchange for each share of our common stock theretofore represented by such certificates or book-entry shares.

        Any portion of the exchange fund that remains undistributed to the holders of certificates or book-entry shares for one year after the effective time will be delivered to Novartis upon demand, and any former holder of our common stock entitled to payment of merger consideration who has not yet complied with the provisions for exchange may thereafter look only to Novartis for payment of its claim for merger consideration. Further, if any certificate or book-entry share has not been surrendered immediately prior to the date on which the merger consideration in respect of such certificate or book-entry share would otherwise escheat to or become the property of any governmental entity, any merger consideration related to such certificate or book-entry share will, to the extent permitted by applicable law, become the property of the surviving corporation, free and clear of all claims or interest of any person previously entitled thereto.

Representations and Warranties; Material Adverse Effect

        The merger agreement contains representations and warranties made by Endocyte, subject to certain exceptions in the merger agreement, in the confidential disclosure letter delivered in connection with the merger agreement and in certain of Endocyte's public filings, as to, among other things:

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        The merger agreement also contains representations and warranties made by Novartis and Merger Sub, subject to certain exceptions in the merger agreement, as to, among other things:

        Some of the representations and warranties in the merger agreement are qualified by materiality or knowledge qualifications or a "material adverse effect" qualification with respect to either Endocyte or Novartis, as discussed below.

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        For purposes of the description of the merger agreement, a "material adverse effect with respect to Endocyte" means any change, event, effect, development or occurrence that (i) has a material adverse effect on the business, assets, financial condition or results of operations of Endocyte, or (ii) prevents or materially impairs or delays the consummation of the merger and the other transactions contemplated by the merger agreement or the ability of Endocyte to perform its obligations under the merger agreement; provided, however, that with respect to clause (i) only, none of the following will be deemed either alone or in combination to constitute, and except as otherwise provided for below none of the following will be taken into account in determining whether there has been, a material adverse effect with respect to Endocyte: any change, event, effect, development or occurrence to the extent resulting from or arising in connection with:

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except (A) in the case of any of the first through fifth bullet points above, to the extent that Endocyte is disproportionately affected thereby as compared with other participants in the industries in which Endocyte operates (in which case the incremental disproportionate impact or impacts may be taken into account in determining whether there has been material adverse effect with respect to Endocyte) and (B) in the case of any of the last three bullet points above, to the extent that any such change, event, effect, development or occurrence results from (I) any action taken (or the failure to take any action) by or at the direction of Endocyte constituting fraud, gross negligence or violation of applicable law or (II) any willful and material failure on the part of Endocyte to comply with the approved clinical protocol for the development of any pharmaceutical product (in which case such change, event, effect, development or occurrence may be taken into account in determining whether there has been a material adverse effect with respect to Endocyte).

        For purposes of the description of the merger agreement, a "material adverse effect with respect to Novartis" means any change, effect, event, fact, development or occurrence that prevents or materially impairs or delays the consummation of the merger and the other transactions contemplated by the merger agreement or the ability of Novartis or Merger Sub to perform its obligations under the merger agreement.

Conduct of Business Pending the Merger

        The merger agreement provides that, from the date of the merger agreement to the effective time, except as set forth in the disclosure letter, or as otherwise expressly contemplated by the merger agreement or required by applicable law or with the prior written consent of Novartis, we will conduct our businesses in the ordinary course of business consistent with past practice, and we will use reasonable best efforts to preserve our present organization, assets, employees, governmental entity authorizations, contractors and relationships with customers, distributors, strategic partners, governmental entities, licensors, licensees and others having material business dealings with us.

        The merger agreement further provides that, from the date of the merger agreement to the effective time, except as set forth in the disclosure letter, or as otherwise expressly contemplated by the merger agreement or required by applicable law or with the prior written consent of Novartis, we will not:

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No Solicitation; Alternative Proposals

        Under the terms of the merger agreement, subject to certain exceptions described below, Endocyte has agreed that it will not, and will cause each of its affiliates not to, and will instruct and use its reasonable best efforts to cause its and their respective directors, officers, employees, financial advisors, legal counsel and other agents, advisors or representatives (collectively, "representatives") not to, directly or indirectly:

        For purposes of the merger agreement:

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        We have also agreed that we will, and will cause each of our affiliates to, and will instruct and use our reasonable best efforts to cause our and their respective representatives to, immediately:

The merger agreement provides that we will not, and will cause each of our affiliates not to, and will instruct and use our reasonable best efforts to cause our and their respective representatives not to, release any person from, or waive, amend or modify any provision of, or grant any permission under any "standstill" provision or similar provision with respect to any of our capital stock in any agreement to which we or any of our affiliates is a party. However, our board or any committee thereof is permitted to grant waivers of, and not to enforce, any "standstill" or similar provision to the extent that (i) our board or any committee thereof determines in good faith (after consultation with our outside

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counsel) that the failure to take such action would be inconsistent with our directors' fiduciary duties under applicable law and (ii) any such action by our board or any committee thereof does not violate any other provision of the merger agreement. Under the merger agreement, we released Novartis and Merger Sub and their respective affiliates from the "standstill" provisions contained in the confidentiality agreement between us and Novartis.

        Notwithstanding these restrictions or anything to the contrary in any other provision of the merger agreement, if at any time prior to the time the requisite stockholder vote is obtained, we or any of our affiliates or representatives receives a bona fide, written takeover proposal that did not result from a breach of the merger agreement, then in response to such takeover proposal:

Under the merger agreement, we must notify Novartis prior to (i) contacting any such person or group under the first bullet point above, and (ii) furnishing any information and/or entering into any discussions or negotiations described in the two bullet points above.

        During the period from the date of the merger agreement to the effective time, we are also required to promptly (and in no event later than 24 hours after our knowledge of the receipt thereof):

From and after such notification, we are to keep Novartis fully informed on a reasonably prompt basis of any material developments, discussions or negotiations regarding, or changes to the material terms

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and conditions of, any such takeover proposal or inquiry, including providing to Novartis promptly, and in no event later than 24 hours after receipt thereof, unredacted copies of any additional proposals, counterproposals, draft agreements and material written documents and correspondence exchanged between us or any of our affiliates or our or their representatives, on the one hand, and the person or group or its representatives making such takeover proposal or inquiry, on the other hand, in connection with such takeover proposal or inquiry.

Change in Company Recommendation

        As described in "The Merger (Proposal 1)—Reasons for the Recommendation of the Special Committee and our Board" beginning on page 40, and subject to the provisions described below, our board has unanimously recommended that our stockholders vote "FOR" the proposal to adopt the merger agreement. We refer in this proxy statement to the following recommendation as the "company recommendation": our board and its special committee (i) determining that the merger agreement and the transactions contemplated by the merger agreement, including the merger, are fair to and in the best interests of Endocyte and its stockholders, (ii) approving and declaring advisable the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement, and (iii) recommending (A) in the case of the special committee, that our board approve the merger agreement and the transactions contemplated by the merger agreement, including the merger, in each case on the terms and subject to the conditions set forth in the merger agreement and (B) in the case of our board, that the holders of shares of our common stock adopt the merger agreement and directing that the merger agreement be submitted to our stockholders at the special stockholders meeting.

        The merger agreement provides that, except as described below, our board or any committee thereof may not:

        Notwithstanding anything to the contrary set forth in the merger agreement, prior to obtaining stockholder approval of the adoption of the merger agreement, our board or any committee thereof may:

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provided, however, that our board and each committee thereof will not, and will cause Endocyte not to, take any action set forth in the bullet points immediately above unless, prior to taking such action:

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provided, further, that any purported termination of the merger agreement pursuant to this sentence will be void and of no force and effect unless such termination is in accordance with the merger agreement and we pay to Novartis the termination fee of $73.5 million prior to or concurrently with such termination.

        Notwithstanding the foregoing, nothing contained in the merger agreement prohibits us from taking and disclosing to our stockholders a position required by Rule 14e-2(a) or Rule 14d-9 promulgated under the Exchange Act, in each case after commencement of a tender offer (within the meaning of Rule 14d-2 promulgated under the Exchange Act). Furthermore, no disclosure that our board or any committee thereof may determine (after consultation with our outside counsel) that we are required to make under applicable law will constitute a violation of the merger agreement. However, in no event will our board or any committee thereof make an adverse recommendation change except in accordance with the merger agreement.

Efforts to Obtain Regulatory Approvals

        Under the merger agreement, each party is required to use its reasonable best efforts to take, or cause to be taken, all actions and to do, or cause to be done, and to assist and cooperate with the other parties in doing, all things necessary, proper or advisable to consummate and make effective, as promptly as practicable, the transactions contemplated by the merger agreement, including:

except with respect to consents, registrations, declarations, filings, instruments and proceedings relating to or under the HSR Act, Section 721 or any other required regulatory approval, which are addressed below.

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        Under the merger agreement, each party is also required to use its reasonable best efforts to take, or cause to be taken, all appropriate actions, and to do, or cause to be done, all things necessary, proper or advisable under applicable law or otherwise to:

Without limiting the generality of the foregoing and subject to the next paragraph, Novartis agrees that, other than with respect to any required regulatory approval under Section 721, its obligation to use its reasonable best efforts pursuant to this provision includes (i) defending or contesting any proceeding challenging this merger agreement or the consummation of the transactions contemplated thereby, including seeking to have any stay, temporary restraining order, preliminary injunction or permanent injunction entered by any governmental entity vacated or reversed and (ii) proposing, negotiating, effecting or agreeing to effect or executing any settlements, undertakings, consent decrees, stipulations or other agreements with any governmental entity or with any other person, except that Novartis will not be required to take any such action described in clause (ii) that is not conditioned upon the closing of the merger. Further, each party agrees to make an appropriate filing, if necessary, as promptly as reasonably practicable, but in any event (A) pursuant to the HSR Act no later than 10 Business Days following the date of the merger agreement and (B) pursuant to Section 721 no later than the first Business Day immediately following November 10, 2018. In addition, each party agrees to make the appropriate filings pursuant to any other required regulatory approval as promptly as reasonably practicable following the date of the merger agreement, and in all cases, to supply as promptly as reasonably practicable to the applicable governmental entity any additional information and documentary material that may be requested pursuant to the HSR Act, Section 721 or the other such required regulatory approval.

        The merger agreement provides that nothing contained therein will require Novartis, Merger Sub or any of their respective subsidiaries to, and Endocyte will not, without the prior written consent of Novartis, propose, negotiate, effect or agree to, or execute any settlements, undertakings, consent decrees, stipulations or other agreements with any governmental entity or with any other person obligating Novartis, any of its subsidiaries or Endocyte to, (i) sell, divest, license or otherwise convey or hold separate any asset or business of Novartis, Endocyte or any of their respective subsidiaries, (ii) terminate any existing relationship, contractual right or obligation of Novartis, any of its subsidiaries or Endocyte, (iii) create any relationship, contractual right or obligation of Novartis, any of its subsidiaries or Endocyte or (iv) implement any limitations or restrictions on the ability of Novartis, Merger Sub or any of their respective subsidiaries to hold and exercise full rights of ownership of any equity interests in the surviving corporation, including the right to vote such equity interests, or to effectively control the business or operations of Endocyte, other than, in the case of clauses (i), (ii) or (iii), any such sale, divestiture, license, conveyance or hold separate, or termination or creation of any relationship, contractual right or obligation, that is exclusively related to any radioligand therapy product under development by Novartis solely for the treatment of prostate cancer as of the date of the merger agreement (any such product, a "permitted product"); provided that the terms and conditions of such sale, divestiture, license, conveyance or hold separate, or termination or creation of any relationship, contractual right or obligation, that is exclusively related to a permitted product would not (A) materially impair the anticipated benefits of the transactions contemplated by the merger agreement to Novartis and its subsidiaries (other than, for the avoidance of doubt, any such benefit

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related to such permitted product), (B) have a material adverse effect on any product currently marketed or under development by Novartis (other than, for the avoidance of doubt, such permitted product) and (C) be on terms and conditions that are unreasonably burdensome to Novartis (a "permitted antitrust action") (each action or condition described in clauses (i)-(iv), other than a permitted antitrust action, a "burdensome condition").

        Under the merger agreement, Novartis and Endocyte also agree to:

In addition, the merger agreement provides that Novartis will control and lead all communications and strategy for dealing with the FTC, the DOJ and any other governmental entity with respect to the HSR Act, Section 721 and any other required regulatory approval, and will control and lead the defense strategy for dealing with any proceedings challenging the merger agreement or the consummation of the transactions contemplated thereby that are brought by or relate to the FTC, the DOJ or any other governmental entity with respect to the HSR Act, Section 721 or any other required regulatory approval.

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Endocyte Stockholders' Meeting

        Under the merger agreement, we agreed to take all necessary actions in accordance with applicable law, our certificate of incorporation and our bylaws and the rules and regulations of The Nasdaq Stock Market, to duly call, give notice of, convene and hold a meeting of our stockholders for the purpose of obtaining stockholder approval of the proposal to adopt the merger agreement, as soon as reasonably practicable after the SEC confirms that it will not review or that it has no further comments on the preliminary proxy statement. Subject to the merger agreement, we will take all lawful action necessary to solicit and obtain the stockholder approval of the proposal to adopt the merger agreement, including engaging a proxy solicitation firm for the purpose of assisting in the solicitation of proxies for the special meeting.

        We may, after consultation with Novartis, adjourn, recess or postpone the special stockholders meeting only (i) to the extent required by applicable law to ensure that any required supplement or amendment to the proxy statement is provided to our stockholders of the Company within a reasonable amount of time in advance of the meeting, (ii) to the extent required by a court of competent jurisdiction in connection with any proceedings, or (iii) if, as of the time for which the stockholders meeting is originally scheduled, there are insufficient shares of our common stock represented (either in person or by proxy) to constitute a quorum necessary to conduct the business of our stockholder meeting, in each case for the minimum duration necessary to remedy the circumstances giving rise to such adjournment, recess or postponement (and in any event, unless otherwise required by applicable law or a court of competent jurisdiction, not beyond the earlier of (A) the date that is 30 days after the date that the stockholders meeting was originally scheduled (or, if applicable, 30 days after the newly scheduled date for any such originally scheduled stockholders meeting that is adjourned, recessed or postponed in accordance with the merger agreement), and (B) three business days prior to the Outside Date).

        Notwithstanding anything to the contrary in the merger agreement (including any adverse recommendation change), unless the merger agreement has been terminated in accordance with its terms prior to the time of the stockholders meeting, the stockholders meeting will be convened and the merger agreement will be submitted to our stockholders at the meeting for the purpose of obtaining the stockholder approval of the proposal to adopt the merger agreement, and nothing contained in the merger agreement will be deemed to relieve Endocyte of these obligations.

Employee Matters

        The merger agreement provides for the following treatment with respect to those employees of Endocyte who continue to be employed by the surviving corporation or one of its subsidiaries after the effective time, whom we refer to as the "continuing employees":

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Indemnification and Insurance

        Under the merger agreement, Novartis has agreed to cause the surviving corporation to assume the obligations with respect to all rights to indemnification, advancement of expenses and exculpation from liabilities, for acts or omissions occurring at or prior to the effective time existing in favor of our current or former directors or officers as provided in our certificate of incorporation, our bylaws or any indemnification agreement between such indemnified person and us, without further action, as of the effective time. Such obligations will survive the merger, will continue in full force and effect in accordance with their terms and will not be impaired by any modification of such terms in any amendment or restatement of our certificate of incorporation or bylaws following the effective time.

        Novartis has also agreed to obtain, or cause the surviving corporation to obtain, at or prior to the effective time, a prepaid (or "tail") directors' and officers' liability insurance policy in respect of acts or omissions occurring at or prior to the effective time, covering each person currently covered by our directors' and officers' liability insurance policies, with coverage for six years following the effective time, on terms with respect to such coverage and amounts no less favorable to the insureds than those of such policy in effect on the date of the merger agreement, up to coverage for an annual premium that does not exceed 300% of the most recent annual premium paid by us for such insurance for our current fiscal year.

        In the event Novartis or the surviving corporation or any of their respective successors or assigns (i) consolidates with or merges into any other person and is not the continuing or surviving corporation or entity of such consolidation or merger or (ii) transfers all or substantially all of its properties and assets to any person, then, and in each such case, Novartis or the surviving corporation will make proper provision so that the successors and assigns of Novartis or the surviving corporation, as the case may be, or at Novartis' option, Novartis, will assume the indemnification and insurance obligations set forth above.

Coordination on Litigation

        The merger agreement requires us to promptly advise Novartis of any proceeding commenced or, to our knowledge, threatened by, a stockholder or holder of any of our equity interests, against us or our directors or executive officers relating to the merger or any of the other transactions contemplated by the merger agreement, and we are to keep Novartis reasonably informed, consult with Novartis

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regarding and give Novartis the opportunity to participate in the defense and settlement of any such proceeding. The merger agreement provides that we and our representatives may not agree to or propose any settlement of any such proceeding without Novartis' prior written consent.

Other Covenants and Agreements

        The merger agreement also contains additional covenants, including, among others, covenants relating to the filing of this proxy statement, access to information, obtaining required consents and regulatory approvals, making necessary notifications and filings, public announcements relating to the merger and tax matters.

Conditions to Completion of the Merger

        Each party's obligation to effect the merger is subject to the satisfaction (or, to the extent permitted by applicable law, waiver by the parties entitled thereto) on or prior to the closing date of the following conditions:

        The obligations of Novartis and Merger Sub to effect the merger are subject to the satisfaction (or, to the extent permitted by law, waiver by Novartis and Merger Sub) on or prior to the closing date of the following additional conditions:

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        The obligation of Endocyte to effect the merger is subject to the satisfaction (or, to the extent permitted by law, waiver by Endocyte) on or prior to the closing date of the following additional conditions:

Termination

        In general, the merger agreement may be terminated at any time prior to the effective time, whether before or after approval of the proposal to adopt the merger agreement by our stockholders (except as otherwise expressly noted), in the following ways:

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Fees and Expenses

        Except as otherwise provided in the merger agreement (including the termination fees and expense reimbursement discussed below), all costs and expenses incurred in connection with the merger agreement, the merger and the other transactions contemplated by the merger agreement are to be paid by the party incurring such fees or expenses, whether or not the merger and the other transactions contemplated by the merger agreement are consummated.

Termination Fees and Expense Reimbursement

        The merger agreement provides that Endocyte will pay Novartis a termination fee of $73.5 million if:

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        The amount of this termination fee will be reduced by the amount, if any, of Novartis' expenses that Endocyte previously and actually pays pursuant to the following provision. The merger agreement also provides that in the event that either Novartis or Endocyte terminates the merger agreement due to the reason that our stockholders do not approve the proposal to adopt the merger agreement at the special meeting, then we will pay to Novartis promptly all reasonable out-of-pocket fees and expenses (including all due diligence fees, all filing and printing fees and all fees and expenses of counsel, accountants, investment bankers, experts and consultants) incurred by Novartis, Merger Sub or their respective affiliates in connection with the merger agreement and the transactions contemplated thereby, except that we will not be obligated to pay for any such expenses in excess of $5.0 million.

        The merger agreement provides that Novartis will pay Endocyte a reverse termination fee of $150.0 million if:

        In no event will either Endocyte or Novartis be required to pay its respective termination fee more than once.

        In the event that Endocyte pays a termination fee, it will constitute the sole and exclusive monetary damages remedy of Novartis and Merger Sub against Endocyte and its current, former or future directors, officers, employees and affiliates for any loss suffered as a result of the failure of the merger or the other transactions contemplated by the merger agreement to be consummated or for a breach or failure to perform under the merger agreement or otherwise (so long as any termination of the merger agreement by Endocyte was in accordance with the applicable provision of the merger agreement), and none of Endocyte or any of its current, former or future directors, officers employees or affiliates will have any further monetary liability or obligation relating to or arising out of the

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merger agreement, the merger or the other transactions contemplated by the merger agreement, except for claims in connection with fraud or willful and material breach of the merger agreement by Endocyte.

        In the event that Novartis pays a reverse termination fee, it will constitute the sole and exclusive monetary damages remedy of Endocyte against Novartis and Merger Sub and their respective current, former or future directors, officers, employees and affiliates for any loss suffered as a result of the failure of the merger or the other transactions contemplated by the merger agreement to be consummated or for a breach or failure to perform under the merger agreement or otherwise (so long as any termination of the merger agreement by Novartis was in accordance with the applicable provision of the merger agreement), and none of Novartis or Merger Sub or any of their respective current, former or future directors, officers, employees or affiliates will have any further liability or obligation relating to or arising out of the merger agreement, the merger or the other transactions contemplated by the merger agreement, except for claims in connection with fraud or willful and material breach of the merger agreement by Novartis or Merger Sub.

Amendment and Modification

        The merger agreement may be amended, modified and supplemented in any and all respects only by an instrument in writing signed on behalf of each of the parties. However, there may be no amendment, modification or supplement to the merger agreement (i) after receipt of approval by our stockholders of the adoption of the merger agreement which requires further approval by our stockholders without the further approval of such stockholders or (ii) after the effective time of the merger.

Extensions and Waivers

        At any time prior to the effective time, the parties (treating Novartis and Merger Sub as one party for this purpose) may (i) extend the time for the performance of any of the obligations or other acts of the other party, (ii) waive any inaccuracies in the representations and warranties of the other party contained in the merger agreement or in any document delivered pursuant to the merger agreement or (iii) waive compliance by the other party with any of the agreements or conditions contained in the merger agreement. Any agreement on the part of a party to an extension or waiver with respect to the merger agreement will be valid only if set forth in an instrument in writing signed on behalf of such party.

Governing Law

        The merger agreement will be governed by and construed in accordance with the laws of the State of Delaware (regardless of the laws that might otherwise govern under applicable principles of conflicts of laws thereof).

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ADVISORY VOTE ON NAMED EXECUTIVE OFFICER MERGER-RELATED COMPENSATION
(PROPOSAL 2)

        As required by Section 14A of the Exchange Act and the applicable SEC rules issued thereunder, we are providing our stockholders with a separate advisory (non-binding) vote to approve certain compensation that may be paid or become payable to our named executive officers in connection with the merger, as described in the table entitled "Quantification of Payments and Benefits to Endocyte Named Executive Officers" under "The Merger (Proposal 1)—Interests of Endocyte's Directors and Executive Officers in the Merger," including the footnotes to the table and related narrative discussion. Accordingly, we are requesting that our stockholders approve the following resolution on an advisory (non-binding) basis:

        The vote on the named executive officer merger-related compensation proposal is a vote separate and apart from the vote on the proposal to adopt the merger agreement. Accordingly, you may vote to adopt the merger agreement and vote not to approve the named executive officer merger-related compensation proposal and vice versa. Because the vote on the named executive officer merger-related compensation proposal is advisory only, it will not be binding on either Endocyte or Novartis. Accordingly, if the merger agreement is adopted and the merger is completed, the merger-related compensation will be payable, subject only to the conditions applicable thereto under the applicable compensation agreements and arrangements, regardless of the outcome of the non-binding, advisory vote of our stockholders.

        The above resolution approving the merger-related compensation of our named executive officers on an advisory basis requires the affirmative vote of a majority of the voting power of the shares of our common stock present in person or represented by proxy at the special meeting and entitled to vote thereon.

        Our board unanimously recommends that the stockholders of Endocyte vote "FOR" the named executive officer merger-related compensation proposal.

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AUTHORITY TO ADJOURN THE SPECIAL MEETING (PROPOSAL 3)

        Our stockholders may be asked to vote on a proposal to adjourn the special meeting, if necessary or appropriate, including to solicit additional proxies if there are insufficient votes at the time of the special meeting to approve the proposal to adopt the merger agreement.

        We do not anticipate calling a vote on this proposal if the proposal to adopt the merger agreement is approved by at least a majority of the outstanding shares of our common stock as of the record date.

        The vote on the adjournment proposal is a vote separate and apart from the vote on the proposal to adopt the merger agreement. Accordingly, you may vote to approve the proposal to adopt the merger agreement and vote not to approve the adjournment proposal and vice versa.

        Approval of the adjournment proposal requires the affirmative vote of a majority of the voting power of the shares of our common stock present in person or represented by proxy at the special meeting and entitled to vote thereon.

        Our board unanimously recommends that the stockholders of Endocyte vote "FOR" the adjournment proposal, if a vote on such proposal is called.

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MARKET PRICE OF ENDOCYTE'S COMMON STOCK

        Our common stock is traded on the Nasdaq Global Market under the symbol "ECYT."

        The following table sets forth the high and low intraday sale prices per share of our common stock, as reported on the Nasdaq Global Market, for the periods indicated:

 
  High   Low  

Fiscal year ending December 31, 2018

             

Fourth quarter (through October 30, 2018)

  $ 23.73   $ 14.50  

Third quarter

  $ 20.85   $ 13.47  

Second quarter

  $ 15.45   $ 8.03  

First quarter

  $ 11.54   $ 2.81  

Fiscal year ended December 31, 2017

             

Fourth quarter

  $ 6.55   $ 1.63  

Third quarter

  $ 1.55   $ 1.17  

Second quarter

  $ 2.98   $ 1.43  

First quarter

  $ 2.74   $ 1.98  

Fiscal year ended December 31, 2016

             

Fourth quarter

  $ 3.49   $ 2.52  

Third quarter

  $ 3.38   $ 2.90  

Second quarter

  $ 4.33   $ 3.06  

First quarter

  $ 3.99   $ 2.65  

        The closing sale price of our common stock on October 17, 2018, which was the last trading day before the merger was publicly announced, was $15.56 per share. On [                        ], 2018, the most recent practicable date before the filing of this proxy statement, the closing price of our common stock was $[            ] per share. You are encouraged to obtain current market quotations for our common stock in connection with voting your shares of our common stock.

        We have never declared or paid any dividends on our capital stock. We currently intend to retain all future earnings for the operation and expansion of our business and, therefore, we do not anticipate declaring or paying cash dividends for the foreseeable future. The merger agreement prohibits us from declaring or paying any dividends on our capital stock during the pre-closing period without Novartis' consent.

        If the merger is consummated, then our common stock will be delisted from the Nasdaq Global Market, there will be no further public market for shares of our common stock and each share of our common stock (other than appraisal shares and excluded shares) will be converted into the right to receive $24.00 in cash, without interest and less any applicable withholding taxes.

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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

        The following table provides information with respect to the beneficial ownership of our common stock as of October 29, 2018 by (i) each stockholder known to us to be the beneficial owner of more than 5% of our outstanding our common stock, (ii) each of our directors, (iii) each of our named executive officers, and (iv) all of our current executive officers and directors as a group. Percentage of beneficial ownership is based on 82,088,638 shares of our common stock outstanding as of October 29, 2018.

        We have determined beneficial ownership in accordance with the rules of the SEC. Except as indicated by the footnotes to the tables below, we believe, based on the information furnished to us, that the persons and entities named in the tables below have sole voting and investment power with respect to all shares of our common stock that they beneficially own. Unless otherwise noted, the address of each person listed on the table is c/o Endocyte, Inc., 3000 Kent Avenue, Suite A1-100, West Lafayette, Indiana 47906.

 
  Shares
Name and Address of Beneficial Owner
  Number of
Shares
  %

RA Capital Management, LLC(1)

    5,864,648   7.14

20 Park Plaza, Suite 1200, Boston, MA 02116

         

Partner Fund Management, L.P.(2)

    5,191,594   6.32

4 Embarcadero Center, Suite 3500, San Francisco CA 94111

         

Venrock Healthcare Capital Partners II, LP(3)

    4,300,000   5.24

530 Fifth Avenue, 22nd Floor, New York, NY 10036

         

Michael A. Sherman(4)

    744,532   *

Michael T. Andriole(5)

    57,082   *

Alison A. Armour, M.D.(6)

    118,540   *

Christopher P. Leamon, Ph.D.(7)

    453,985   *

Katherine K. Parker(8)

    136,069   *

John C. Aplin, Ph.D.(9)

    139,069   *

Colin Goddard(10)

    96,300   *

Marc D. Kozin(11)

    102,300   *

Philip S. Low, Ph.D.(12)

    867,239   1.05

Patrick Machado(13)

    8,750   *

Fred A. Middleton(14)

    4,349,872   5.29

Lesley Russell, M.B., Ch.B.(15)

    110,300   *

Dawn Svoronos

      *

All current directors and executive officers as a group (15 people as of October 29, 2018)(16)

    7,375,394   8.75

*
Less than 1%.

(1)
Based on information provided in a Schedule 13G filed with the SEC on February 14, 2018 and the final allocation of shares sold by us in a public offering that closed on March 2, 2018. The reporting persons consist of RA Capital Management, LLC and Peter Kolchinsky. The reporting persons reported that they may be deemed to have control over various entities that are the beneficial owners of the shares reported in their Schedule 13G, but that they disclaim beneficial ownership over such shares for all other purposes. In their Schedule 13G, the reporting persons reported that they have shared power to vote or to direct the vote of and to dispose or to direct the disposition of 3,364,648 shares. Based on the final allocation from the March offering, RA Capital Management, LLC purchased an additional 2,500,000 shares.

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(2)
Based on information provided in a Schedule 13G/A filed with the SEC on February 14, 2018 and the final allocation of shares sold by us in a public offering that closed on March 2, 2018. The reporting persons consist of Partner Fund Management, L.P., Partner Fund Management GP, LLC, Brian D. Grossman and Christopher M. James. In their Schedule 13G/A, the reporting persons reported that they may be deemed to have control over various entities that are the beneficial owners of the shares reported in that Schedule 13G/A, and that they have shared power to vote or to direct the vote of and to dispose or to direct the disposition of 3,441,594 shares. Based on the final allocation from the March offering, Partner Fund Management, L.P. purchased an additional 1,750,000 shares.

(3)
Based on information provided in a Schedule 13G filed with the SEC on March 12, 2018, reporting ownership of shares of our common stock as of that date. The reporting persons consist of Venrock Healthcare Capital Partners II, L.P. ("VHCP II"), VHCP Co-Investment Holdings II, LLC ("VHCP Co II"), VHCP Management II, LLC, Bong Koh and Nimish Shah. The reporting persons reported that they are members of a group for purposes of the Schedule 13G and that they have shared power to vote or to direct the vote of, and to dispose or to direct the disposition of, 4,300,000 shares. The reporting persons also reported that 3,059,616 of such shares are owned directly by VHCP II and 1,240,384 of such shares are owned directly by VHCP Co II, that VHCP Management II, LLC is the general partner of VHCP II and the manager of VHCP Co II, and that Messrs. Koh and Shah are the managing members of VHCP Management II, LLC.

(4)
Consists of (i) 212,292 shares held by Michael A. Sherman, (ii) 19,919 shares held by Sherman Investors LLC over which Mr. Sherman disclaims beneficial ownership except to the extent of his pecuniary interest therein, and (iii) 512,321 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(5)
Consists of (i) 32,082 shares held by Michael T. Andriole and (ii) 25,000 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(6)
Consists of (i) 33,540 shares held by Alison A. Armour and (ii) 85,000 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(7)
Consists of (i) 62,219 shares held by Christopher P. Leamon and (ii) 391,766 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(8)
Consists of (i) 30,869 shares held by Katherine K. Parker, (ii) 1,200 shares held by Katherine K. Parker revocable trust, and (iii) 104,000 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(9)
Consists of (i) 28,863 shares held by John C. Aplin and (ii) 110,206 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(10)
Consists of (i) 7,800 shares held by Colin Goddard and (ii) 88,500 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(11)
Consists of (i) 7,800 shares held by Marc D. Kozin and (ii) 94,500 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(12)
Consists of (i) 174,830 shares held by Philip S. Low revocable trust, (ii) 184,985 shares held by Joan Low revocable trust, (iii) 86,720 shares held by Philip S. Low and (iv) 420,704 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

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(13)
Consists of (i) 1,250 shares held by Patrick Machado and (ii) 7,500 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(14)
Consists of (i) 4,045,617 shares held by entities affiliated with Sanderling Ventures, (ii) 194,049 shares held by Fred A. Middleton, and (iii) 110,206 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018. Mr. Middleton is a managing director of Middleton, McNeil & Mills Associates V, LLC which has the ultimate voting and investment power over shares held of record by Sanderling V Beteiligungs GmbH & Co. KG, Sanderling V Biomedical Co-Investment Fund, L.P., Sanderling V Biomedical, L.P., Sanderling V Limited Partnership, Sanderling Venture Partners V Co-Investment Fund, L.P., Sanderling Venture Partners V, L.P., Sanderling Venture Partners VI Co-Investment Fund, L.P., Sanderling VI Beteiligungs GmbH and Co. KG, Sanderling VI Limited Partnership, and Sanderling V Strategic Exit Fund, L.P., and he may be deemed to have voting and investment power over shares held of record by those entities. Mr. Middleton disclaims beneficial ownership of the shares directly held by the entities affiliated with Sanderling except to the extent of his individual pecuniary interest therein.

(15)
Consists of (i) 7,800 shares held by Lesley Russell and (ii) 102,500 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.

(16)
Includes 2,210,120 shares issuable upon exercise of options exercisable within 60 days of October 29, 2018.


APPRAISAL RIGHTS

        If the merger is consummated, Endocyte's stockholders who do not vote in favor of the adoption of the merger agreement, who properly demand an appraisal of their shares in accordance with Section 262 of the DGCL ("Section 262"), who continuously hold such shares through the effective time of the merger, who otherwise comply with the applicable procedures and requirements of Section 262 (including with respect to certain aggregate ownership requirements) and who do not withdraw their demands, waive or otherwise lose their rights to appraisal will, subject to certain conditions and limitations under the DGCL, be entitled to seek appraisal of their shares in connection with the merger under Section 262. Unless the context requires otherwise, all references in Section 262 and in this summary to a "stockholder" or to a "holder of shares" are to a record holder of Endocyte common stock.

        The following discussion is not a complete statement of the law pertaining to appraisal rights under the DGCL and is qualified in its entirety by the full text of Section 262, which is attached to this proxy statement as Annex B and incorporated into this proxy statement by reference. The following summary does not constitute any legal or other advice and does not constitute a recommendation that the Endocyte stockholders exercise their appraisal rights under Section 262. Only a holder of record of shares of Endocyte common stock is entitled to demand appraisal of the shares registered in that holder's name. A person having a beneficial interest in shares of common stock held of record in the name of another person, such as a bank, broker or other nominee, must act promptly to cause the record holder to demand an appraisal of such holder's shares. If you hold your shares of Endocyte common stock through a bank, broker or other nominee and you wish to exercise appraisal rights, you should consult with your bank, broker or the other nominee to ensure that appraisal rights are exercised. Stockholders should carefully review the full text of Section 262, as well as the information discussed below.

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        Under Section 262, if the merger is completed, holders of record of shares of Endocyte common stock who (1) submit a written demand for appraisal of such stockholder's shares to Endocyte prior to the vote on the adoption of the merger agreement; (2) do not vote in favor of the adoption of the merger agreement; (3) continuously are the record holders of such shares through the effective time of the merger; (4) otherwise comply with the procedures and satisfy certain ownership thresholds set forth in Section 262; and (5) have not validly withdrawn, waived or otherwise lost such appraisal rights may be entitled to have their shares of Endocyte common stock appraised by the Delaware Court of Chancery and to receive payment in cash of the "fair value" of such shares of Endocyte common stock, exclusive of any element of value arising from the accomplishment or expectation of the merger, together with interest, if any, to be paid on the amount determined to be "fair value" as determined by the Delaware Court of Chancery in lieu of the right to receive the merger consideration. However, after an appraisal petition has been filed, the Delaware Court of Chancery will dismiss appraisal proceedings as to all Endocyte stockholders who are otherwise entitled to appraisal rights unless (a) the total number of shares of Endocyte common stock for which appraisal rights have been pursued and perfected exceeds 1% of the outstanding shares of Endocyte common stock as measured in accordance with subsection (g) of Section 262 or (b) the value of the merger consideration in respect of the total number of such shares exceeds $1 million ((a) or (b), "ownership thresholds"). Unless the Delaware Court of Chancery in its discretion determines otherwise for good cause shown, and except as otherwise provided in Section 262, interest on an appraisal award will accrue and compound quarterly from the effective time of the merger through the date the judgment is paid at 5% over the Federal Reserve discount rate (including any surcharge) as established from time to time during such period; provided, however, that if at any time before the Delaware Court of Chancery enters judgment in the appraisal proceeding, the surviving corporation pays to each stockholder entitled to appraisal an amount in cash, interest will accrue after the time of such payment only on the amount that equals the sum of (1) the difference, if any, between the amount so paid and the "fair value" of the shares as determined by the Delaware Court of Chancery and (2) interest accrued prior to the time of such voluntary payment, unless paid at such time. The surviving corporation is under no obligation to make such voluntary cash payment prior to such entry of judgment.

        Under Section 262, when a merger agreement is to be submitted for approval at a meeting of stockholders as in the case of the adoption of the merger agreement, Endocyte, not less than 20 days prior to the meeting, must notify each of its stockholders of record as of the record date for notice of such meeting that appraisal rights are available and include in the notice a copy of Section 262. This proxy statement constitutes Endocyte's required notice to stockholders that appraisal rights are available in connection with the merger, and the full text of Section 262 is attached to this proxy statement as Annex B. In connection with the merger, any holder of shares of Endocyte common stock who wishes to exercise appraisal rights, or who wishes to preserve such holder's right to do so, should review this section and Annex B carefully. Failure to strictly comply with the requirements of Section 262 in a timely and proper manner may result in the loss of appraisal rights under the DGCL. A stockholder who loses his, her or its appraisal rights will be entitled to receive the merger consideration without interest and less any applicable withholding taxes, in accordance with the merger agreement. Moreover, because of the complexity of the procedures for exercising the right to seek appraisal of shares of Endocyte common stock, Endocyte believes that if a stockholder considers exercising such rights, that stockholder should seek the advice of legal counsel.

        Stockholders wishing to exercise the right to seek an appraisal of their shares of Endocyte common stock must do ALL of the following:

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        In addition, one of the ownership thresholds set forth in Section 262 must be met by the stockholders wishing to exercise the right to seek an appraisal of their shares of Endocyte common stock.

        Because a proxy that is signed and submitted but does not otherwise contain voting instructions will, unless revoked, be voted in favor of the adoption of the merger agreement, a stockholder who votes by proxy and who wishes to exercise appraisal rights must vote against the adoption of the merger agreement or abstain from voting his, her or its shares.

        A stockholder wishing to exercise appraisal rights must deliver to Endocyte, before the vote on the adoption of the merger agreement at the special meeting at which the proposal to adopt the merger agreement will be submitted to the stockholders, a written demand for the appraisal of such stockholder's shares, and that stockholder must not vote, in person or by proxy, in favor of the adoption of the merger agreement. A vote in favor of the adoption of the merger agreement, in person at the special meeting or by proxy (whether by mail or via the Internet or telephone), will constitute a waiver of your appraisal rights in respect of the shares so voted and will nullify any previously filed written demands for appraisal. A stockholder exercising appraisal rights must hold the shares of record on the date the written demand for appraisal is made and must continue to hold the shares of record through the effective time of the merger. A proxy that is signed and submitted but does not otherwise contain voting instructions will, unless revoked, be voted in favor of the adoption of the merger agreement, and it will constitute a waiver of the stockholder's right of appraisal and will nullify any previously delivered written demand for appraisal. Therefore, a stockholder who submits a proxy and who wishes to exercise appraisal rights must submit a proxy containing instructions to vote against the adoption of the merger agreement or abstain from voting on the adoption of the merger agreement. Neither voting, in person or by proxy, against the adoption of the merger agreement nor abstaining from voting or failing to vote on the proposal to adopt the merger agreement will, in and of itself, constitute a written demand for appraisal satisfying the requirements of Section 262. The written demand for appraisal must be in addition to and separate from any proxy or vote on the adoption of the merger agreement. A stockholder's failure to make the written demand prior to the taking of the vote on the adoption of the merger agreement at the special meeting will constitute a waiver of appraisal rights.

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        Only a holder of record of shares of Endocyte common stock is entitled to demand appraisal rights for the shares registered in that holder's name. A demand for appraisal in respect of shares of Endocyte common stock should be executed by or on behalf of the holder of record, and must reasonably inform Endocyte of the identity of the holder and state that the stockholder intends thereby to demand an appraisal of such stockholder's shares. If the shares are owned of record in a fiduciary or representative capacity, such as by a trustee, guardian or custodian, such demand must be executed by or on behalf of the record owner. A record owner, such as a bank, brokerage firm or other nominee, who holds shares of Endocyte common stock as a nominee for others, may exercise his, her or its right of appraisal with respect to the shares of Endocyte common stock held for one or more beneficial owners, while not exercising this right for other beneficial owners. In that case, the written demand should state the number of shares of Endocyte common stock as to which appraisal is sought. If a stockholder holds shares of Endocyte common stock through a broker who in turn holds the shares through a central securities depository nominee such as Cede & Co., a demand for appraisal of such shares must be made by or on behalf of the depository nominee and must identify the depository nominee as record holder.

        If the shares are owned of record jointly by more than one person, as in a joint tenancy or tenancy in common, the demand for appraisal should be executed by or on behalf of all joint owners. An authorized agent, including an authorized agent for two or more joint owners, may execute a demand for appraisal on behalf of a holder of record; however, the agent must identify the record owner or owners and expressly disclose that, in executing the demand, the agent is acting as agent for the record owner or owners.

        STOCKHOLDERS WHO HOLD THEIR SHARES IN "STREET NAME" BY A BROKER, BANK, TRUST OR OTHER NOMINEE AND WHO WISH TO EXERCISE APPRAISAL RIGHTS SHOULD CONSULT WITH THEIR BANK, BROKER, TRUST OR OTHER NOMINEES, AS APPLICABLE, TO DETERMINE THE APPROPRIATE PROCEDURES FOR THE BANK, BROKER, TRUST OR OTHER NOMINEE TO MAKE A DEMAND FOR APPRAISAL OF THOSE SHARES. A PERSON HAVING A BENEFICIAL INTEREST IN SHARES HELD OF RECORD IN THE NAME OF ANOTHER PERSON, SUCH AS A BANK, BROKER, TRUST OR OTHER NOMINEE, MUST ACT PROMPTLY TO CAUSE THE RECORD HOLDER TO FOLLOW PROPERLY AND IN A TIMELY MANNER THE STEPS NECESSARY TO PERFECT APPRAISAL RIGHTS.

        All written demands for appraisal pursuant to Section 262 should be mailed or delivered to:

Endocyte, Inc.
8910 Purdue Road, Suite 250
Indianapolis, Indiana 46268
Attention: Corporate Secretary

        At any time within 60 days after the effective date of the merger, any holder of shares of Endocyte common stock that has not commenced an appraisal proceeding or joined an appraisal proceeding as a named party may withdraw his, her or its demand for appraisal and accept the merger consideration, without interest and less any applicable withholding taxes, in accordance with the merger agreement, by delivering to Endocyte, as the surviving corporation, a written withdrawal of the demand for appraisal. However, any such attempt to withdraw the demand made more than 60 days after the effective time of the merger will require written approval of the surviving corporation. Notwithstanding the foregoing, no appraisal proceeding in the Delaware Court of Chancery will be dismissed as to any stockholder without the approval of the Delaware Court of Chancery, and such approval may be conditioned upon such terms as the Delaware Court of Chancery deems just; provided, however, that this shall not affect the right of any stockholder who has not commenced an appraisal proceeding or joined that proceeding as a named party to withdraw such stockholder's demand for appraisal and to accept the merger

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consideration within 60 days after the effective time of the merger. If Endocyte, as the surviving corporation, does not approve a request to withdraw a demand for appraisal when that approval is required, or, except with respect to any stockholder who withdraws such stockholder's demand in accordance with the proviso in the immediately preceding sentence, if the Delaware Court of Chancery does not approve the dismissal of an appraisal proceeding with respect to a stockholder, the stockholder will be entitled to receive only the appraised value of such shares determined in any such appraisal proceeding, which value could be less than, equal to or more than the merger consideration being offered pursuant to the merger agreement.

        If the merger is completed, within ten days after the effective time of the merger, the surviving corporation will notify each record holder of shares of Endocyte common stock who has properly made a written demand for appraisal pursuant to Section 262, and who has not voted in favor of the adoption of the merger agreement, that the merger has become effective and the effective date thereof.

        Within 120 days after the effective time of the merger, but not thereafter, the surviving corporation or any holder of shares of Endocyte common stock who has complied with Section 262 and is entitled to appraisal rights under Section 262 (or the beneficial owner of such shares) may commence an appraisal proceeding by filing a petition in the Delaware Court of Chancery, with a copy served on the surviving corporation in the case of a petition filed by a stockholder, demanding a determination of the "fair value" of the shares held by all dissenting stockholders entitled to appraisal. The surviving corporation is under no obligation, and has no present intention, to file a petition, and stockholders should not assume that the surviving corporation will file a petition or initiate any negotiations with respect to the "fair value" of the shares of Endocyte common stock. Accordingly, any holders of shares of Endocyte common stock who desire to have their shares appraised should initiate all necessary action to perfect their appraisal rights in respect of their shares of Endocyte common stock within the time period and in the manner prescribed in Section 262. The failure of a holder of Endocyte common stock to file such a petition within the time period specified in Section 262 could nullify the stockholder's previous written demand for an appraisal of such stockholder's shares.

        Within 120 days after the effective time of the merger, any holder of shares of Endocyte common stock who has complied with the requirements for an appraisal of such holder's shares pursuant to Section 262 will be entitled, upon written request, to receive from the surviving corporation a statement setting forth the aggregate number of shares not voted in favor of the adoption of the merger agreement and with respect to which Endocyte has received demands for appraisal, and the aggregate number of holders of such shares. The surviving corporation must mail this statement to the requesting stockholder within ten days after receipt by the surviving corporation of the written request for such a statement or within ten days after the expiration of the period for delivery of demands for appraisal, whichever is later. A beneficial owner of shares of Endocyte common stock held either in a voting trust or by a nominee on behalf of such person may, in such person's own name, file a petition seeking appraisal or request from the surviving corporation the foregoing statements. As noted above, however, the demand for appraisal can only be made by a stockholder of record.

        If a petition for an appraisal is duly filed by a holder of shares of Endocyte common stock and a copy thereof is served upon the surviving corporation, the surviving corporation will then be obligated within 20 days after such service to file with the office of the Register in Chancery in which such petition was filed a duly verified list containing the names and addresses of all stockholders who have demanded payment for their shares and with whom agreements as to the value of their shares have not been reached. Upon the filing of such petition, the Delaware Court of Chancery may order that notice of the time and place fixed for the hearing of such petition be given to the surviving corporation, and

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all of the stockholders shown on the verified list at the addresses stated therein. Any such notice shall also be given by one or more publications at least one week before the day of the hearing in a newspaper of general circulation published in the City of Wilmington, Delaware or any other publication which the Delaware Court of Chancery deems advisable. The costs of any such notices shall be borne by the surviving corporation.

        After notice to dissenting stockholders as required by the Delaware Court of Chancery is delivered, at the hearing on such petition, the Delaware Court of Chancery will determine the stockholders who have complied with Section 262 and who have become entitled to appraisal rights thereunder. The Delaware Court of Chancery may require the stockholders who demanded appraisal for their shares to submit their stock certificates, if such shares are represented by certificates, to the Register in Chancery for notation thereon of the pendency of the appraisal proceedings; and if any stockholder fails to comply with the direction, the Delaware Court of Chancery may dismiss the proceedings as to such stockholder. Upon application by the surviving corporation or by any holder of Endocyte common stock entitled to participate in the appraisal proceeding, the Delaware Court of Chancery may, in its discretion, proceed to trial upon the appraisal prior to the final determination of the stockholders entitled to an appraisal. Any Endocyte stockholder whose name appears on the verified list and who has submitted such stockholder's stock certificates, if any, to the Register in Chancery, if such is required, may participate fully in all proceedings until it is finally determined that such stockholder is not entitled to appraisal rights.

        The Delaware Court of Chancery will dismiss appraisal proceedings as to all Endocyte stockholders who assert appraisal rights unless (a) the total number of shares for which appraisal rights have been pursued and perfected exceeds 1% of the outstanding shares of Endocyte common stock as measured in accordance with subsection (g) of Section 262 or (b) the value of the merger consideration in respect of the shares for which appraisal rights have been pursued and perfected exceeds $1 million.

        After the Delaware Court of Chancery determines the holders of Endocyte common stock entitled to appraisal, that at least one of the ownership thresholds set forth in Section 262 has been satisfied in respect of the Endocyte stockholders seeking appraisal rights and that the demand for appraisal is not validly withdrawn, the appraisal proceeding will be conducted in accordance with the rules of the Delaware Court of Chancery, including any rules specifically governing appraisal proceedings. Through such proceeding, the Delaware Court of Chancery will determine the "fair value" of the shares of Endocyte common stock at the effective time held by dissenting stockholders who have properly exercised his, her or its appraisal rights, exclusive of any element of value arising from the accomplishment or expectation of the merger, together with interest, if any, to be paid upon the amount determined to be the "fair value." When the fair value is determined, the Delaware Court of Chancery will direct the payment of the fair value of the shares, together with interest, if any, by the surviving corporation to the Endocyte stockholders entitled thereto. Payment will be so made to each such stockholder, in the case of holders of uncertificated stock forthwith, and in the case of holders of shares of Endocyte common stock represented by certificates upon the surrender to the surviving corporation of such stockholder's certificates.

        In determining "fair value," the Delaware Court of Chancery will take into account all relevant factors. In Weinberger v. UOP, Inc., the Supreme Court of Delaware discussed the factors that could be considered in determining "fair value" in an appraisal proceeding, stating that "proof of value by any techniques or methods which are generally considered acceptable in the financial community and otherwise admissible in court" should be considered, and that "[f]air price obviously requires consideration of all relevant factors involving the value of a company." The Delaware Supreme Court stated that, in making this determination of "fair value," the court must consider market value, asset value, dividends, earnings prospects, the nature of the enterprise and any other facts that could be

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ascertained as of the date of the merger that throw any light on future prospects of the merged corporation. Section 262 provides that "fair value" is to be "exclusive of any element of value arising from the accomplishment or expectation of the merger." In Cede & Co. v. Technicolor, Inc., the Delaware Supreme Court stated that such exclusion is a "narrow exclusion [that] does not encompass known elements of value," but which rather applies only to the speculative elements of value arising from such accomplishment or expectation. In Weinberger, the Supreme Court of Delaware also stated that "elements of future value, including the nature of the enterprise, which are known or susceptible of proof as of the date of the merger and not the product of speculation, may be considered." In addition, Delaware courts have decided that the statutory appraisal remedy, depending on factual circumstances, may or may not be a dissenter's exclusive remedy.

        Unless the Delaware Court of Chancery in its discretion determines otherwise for good cause shown, and except as otherwise provided in Section 262, interest from the effective date of the merger through the date of payment of the judgment will be compounded quarterly and will accrue at 5% over the Federal Reserve discount rate (including any surcharge) as established from time to time during the period between the effective date of the merger and the date of payment of the judgment. The surviving corporation has the right, at any time prior to the Delaware Court of Chancery's entry of judgment in the proceedings, to make a voluntary cash payment to each stockholder entitled to and seeking appraisal (which will be treated as an advance against the payment due to such Endocyte stockholder). If the surviving corporation makes a voluntary cash payment pursuant to subsection (h) of Section 262, interest will accrue after the time of such payment only upon the sum of (i) the difference, if any, between the amount paid by the surviving corporation in such voluntary cash payment and the "fair value" of the shares as determined by the Delaware Court of Chancery and (ii) interest accrued before such voluntary cash payment, unless paid at such time. The surviving corporation is under no obligation to make such voluntary cash payment prior to such entry of judgment.

        Stockholders considering seeking appraisal should be aware that the "fair value" of their shares as so determined by the Delaware Court of Chancery could be more than, the same as or less than the consideration they would receive pursuant to the merger if they did not seek appraisal of their shares and that an opinion of an investment banking firm as to the fairness from a financial point of view of the consideration payable in a merger is not an opinion as to, and does not in any manner address, "fair value" under Section 262. Although Endocyte believes that the merger consideration is fair, no representation is made as to the outcome of the appraisal of "fair value" as determined by the Delaware Court of Chancery, and stockholders should recognize that such an appraisal could result in a determination of a value higher or lower than, or the same as, the merger consideration. Neither Endocyte nor Novartis anticipates offering more than the merger consideration to any stockholder exercising appraisal rights, and each of Endocyte and Novartis reserves the right to make a voluntary cash payment pursuant to subsection (h) of Section 262 and to assert, in any appraisal proceeding, that for purposes of Section 262, the "fair value" of a share of Endocyte common stock is less than the merger consideration. If a petition for appraisal is not timely filed, or if neither of the ownership thresholds set forth in Section 262 has been satisfied in respect of the Endocyte stockholders seeking appraisal rights, then the right to an appraisal will cease. The costs of the appraisal proceedings (which do not include attorneys' fees or the fees and expenses of experts) may be determined by the Delaware Court of Chancery and taxed upon the parties as the Delaware Court of Chancery deems equitable under the circumstances. Upon application of a stockholder, the Delaware Court of Chancery may also order that all or a portion of the expenses incurred by any stockholder in connection with the appraisal proceeding, including, without limitation, reasonable attorney's fees and the fees and expenses of experts, be charged pro rata against the value of all the shares entitled to an appraisal. In the absence of such determination or assessment, each party bears its own expenses.

        If any stockholder who demands appraisal of his, her or its shares of Endocyte common stock under Section 262 fails to perfect, or waives, loses or validly withdraws, such holder's right to appraisal,

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the stockholder's shares of Endocyte common stock will be deemed to have been converted at the effective time of the merger into the right to receive the merger consideration as provided in the merger agreement. A stockholder will fail to perfect, or effectively lose such holder's right to appraisal if no petition for appraisal is filed within 120 days after the effective time of the merger, if neither of the ownership thresholds set forth in Section 262 has been satisfied in respect of the Endocyte stockholders seeking appraisal rights or if the stockholder delivers to the surviving corporation a written withdrawal of such holder's demand for appraisal and an acceptance of the merger consideration as provided in the merger agreement in accordance with Section 262.

        From and after the effective time of the merger, no stockholder who has demanded appraisal rights in compliance with Section 262 will be entitled to vote such shares of Endocyte common stock for any purpose or to receive payment of dividends or other distributions on the stock (except dividends or other distributions payable to stockholders of record at a record date which is prior to the effective date of the merger); provided, however, that if no petition for an appraisal is filed within the time provided in Section 262, if neither of the ownership thresholds set forth in Section 262 has been satisfied in respect of the Endocyte stockholders seeking appraisal rights or if such stockholder delivers to the surviving corporation a written withdrawal of such stockholder's demand for an appraisal and an acceptance of the merger consideration, either within 60 days after the effective date of the merger or thereafter with the written approval of the surviving corporation, then the right of such stockholder to an appraisal will cease. Notwithstanding the foregoing, no appraisal proceeding in the Delaware Court of Chancery will be dismissed as to any stockholder without the approval of the Court, and such approval may be conditioned upon such terms as the Court deems just; provided, however, that the foregoing shall not affect the right of any stockholder who has not commenced an appraisal proceeding or joined that proceeding as a named party to withdraw such stockholder's demand for appraisal and to accept the terms offered upon the merger within 60 days after the effective date of the merger.

        Failure to comply strictly with all of the procedures set forth in Section 262 may result in the loss of a stockholder's statutory appraisal rights. In that event, you will be entitled to receive the merger consideration for your appraisal shares in accordance with the merger agreement, without interest and less any applicable withholding taxes. Consequently, any stockholder wishing to exercise appraisal rights is encouraged to consult legal counsel before attempting to exercise those rights. To the extent there are any inconsistencies between the foregoing summary and Section 262, Section 262 will govern.


MULTIPLE STOCKHOLDERS SHARING ONE ADDRESS

        In accordance with Rule 14a-3(e)(1) under the Exchange Act, one proxy statement will be delivered to two or more stockholders who share an address, unless Endocyte has received contrary instructions from one or more of the stockholders. Each stockholder will receive a separate proxy card. Endocyte will deliver promptly upon written or oral request a separate copy of the proxy statement to a stockholder at a shared address to which a single copy of the proxy statement was delivered. Requests for additional copies of the proxy statement should be directed to Endocyte in care of the Corporate Secretary at 8910 Purdue Road, Suite 250, Indianapolis, Indiana 46268, Attn: Corporate Secretary, or by calling (765) 463-7175. In addition, stockholders who share a single address, but receive multiple copies of the proxy statement, may request that in the future they receive a single copy by contacting Endocyte at the address and phone number set forth in the prior sentence.


FUTURE STOCKHOLDER PROPOSALS

        If the merger is completed on the expected timetable, we will not hold an annual meeting of stockholders in 2019 (the "2019 annual meeting") or future years. If, however, the merger is not completed, or the outside date is extended as described under "Merger Agreement—Termination", we will hold our 2019 annual meeting.

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        The date by which we must receive stockholder proposals for inclusion in the proxy statement and form of proxy relating to the 2019 annual meeting is November 23, 2018. If the date of the 2019 annual meeting is moved more than 30 days before or after the anniversary date of the 2018 annual meeting of stockholders, the deadline for inclusion of proposals in our proxy statement is instead a reasonable time before we begin to print and mail our proxy materials for the 2019 annual meeting.

        Notice of any director nomination or other proposal that a stockholder intends to present at the 2019 annual meeting, but does not intend to have included in the proxy statement and form of proxy relating to the 2019 annual meeting, must be delivered to our Corporate Secretary by mail at Corporate Secretary, Endocyte, Inc., 8910 Purdue Road, Suite 250, Indianapolis, Indiana 46268 not earlier than the close of business on January 7, 2019 and not later than the close of business on February 6, 2019. If the date of the 2019 annual meeting is advanced by more than 30 days prior to or delayed by more than 60 days after the anniversary date of the 2018 annual meeting of stockholders, then, for notice by the stockholder to be timely, it must be so received by our Corporate Secretary not earlier than the close of business on the 120th day prior to the 2019 annual meeting and not later than the close of business on the later of (i) the 90th day prior to the 2018 annual meeting, or (ii) the tenth day following the day on which public announcement of the date of the 2018 annual meeting is first made. Stockholder proposals must comply with all of the applicable requirements set forth in the rules and regulations of the SEC, including Rule 14a-8, as well as the advance notification requirements set forth in our bylaws. A copy of the advance notification requirements may be obtained upon request to Corporate Secretary, Endocyte, Inc., 8910 Purdue Road, Suite 250, Indianapolis, Indiana 46268.


WHERE YOU CAN FIND ADDITIONAL INFORMATION

        We file annual, quarterly and current reports, proxy statements and other information with the SEC. Our SEC filings are available to the public over the Internet at the SEC's website at www.sec.gov. You may also read and copy any document we file at the SEC's Public Reference Room at 100 F Street, NE, Washington, D.C. 20549. Please call the SEC at 1-800-SEC-0330 for further information on the Public Reference Room.

        Our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K, including any amendments to those reports, and other information that we file with or furnish to the SEC pursuant to Section 13(a) or 15(d) of the Exchange Act, can also be accessed free of charge in the "Investors & News" section of our website, which is located at http://investor.endocyte.com. These filings will be available as soon as reasonably practicable after we electronically file such material with, or furnish it to, the SEC. Information contained on our website is not incorporated by reference into this proxy statement and you should not consider information contained on our website to be part of this proxy statement.

        In addition, you may obtain a copy of the reports, without charge, by writing or telephoning us at: Endocyte, Inc., 8910 Purdue Road, Suite 250, Indianapolis, Indiana 46268, Attn: Corporate Secretary, or (765) 463-7175. Each such request must set forth a good faith representation that, as of the record date, the person making the request was a beneficial owner of our common stock entitled to vote at the special meeting. In order to ensure timely delivery of such documents before the special meeting, any such request should be made promptly to us.


INFORMATION INCORPORATED BY REFERENCE

        The SEC allows us to "incorporate by reference" into this proxy statement the information we file with the SEC. This means that we can disclose important information to you by referring you to those documents. The information incorporated by reference is considered to be a part of this proxy statement, and later information that we file with the SEC will update and supersede that information. Information in documents that is deemed, in accordance with SEC rules, to be furnished and not filed

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will not be deemed to be incorporated by reference into this proxy statement. We incorporate by reference the documents listed below and any documents filed by us pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this proxy statement, and before the date of the special meeting:

        We will provide without charge to each person to whom this proxy statement is delivered, upon written or oral request, a copy of any or all documents that are incorporated by reference into this proxy statement, other than exhibits to such documents unless such exhibits are specifically incorporated by reference into the documents that this proxy statement incorporates. Any such request may be made by writing or telephoning us at the following address or phone number:

Endocyte, Inc.
8910 Purdue Road, Suite 250
Indianapolis, Indiana 46268
Attention: Corporate Secretary
(765) 463-7175


MISCELLANEOUS

        We have supplied all information relating to Endocyte. Novartis has supplied, and we have not independently verified, all of the information relating to Novartis and Merger Sub.

        You should not send in your Endocyte stock certificates until you receive transmittal materials after the merger is completed.

        This proxy statement does not constitute the solicitation of a proxy in any jurisdiction to or from any person to whom or from whom it is unlawful to make such proxy solicitation in that jurisdiction. You should rely only on the information contained or incorporated by reference into this proxy statement to vote your shares at the special meeting. No persons have been authorized to give any information or to make any representations other than those contained in this proxy statement, and, if given or made, such information or representations must not be relied upon as having been authorized by us or any other person. This proxy statement speaks only as of the date indicated on the cover page of this proxy statement. You should not assume that the information contained in this proxy statement is accurate as of any date other than that date, and the mailing of this proxy statement to stockholders does not and will not create any implication to the contrary.

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Annex A

AGREEMENT AND PLAN OF MERGER

dated as of October 17, 2018,

among

NOVARTIS AG,

EDINBURGH MERGER CORPORATION

and

ENDOCYTE, INC.


Table of Contents


TABLE OF CONTENTS

 
   
  Page  

ARTICLE I

 


The Merger


 

SECTION 1.01.

 

The Merger

   
A-1
 

SECTION 1.02.

 

Closing

    A-1  

SECTION 1.03.

 

Effective Time

    A-2  

SECTION 1.04.

 

Effects of Merger

    A-2  

SECTION 1.05.

 

Certificate of Incorporation and Bylaws

    A-2  

SECTION 1.06.

 

Directors and Officers

    A-2  


ARTICLE II


 


Effect on Capital Stock; Payment for Shares


 

SECTION 2.01.

 

Effect on Capital Stock

   
A-2
 

SECTION 2.02.

 

Payment of Merger Consideration

    A-3  


ARTICLE III


 


Representations and Warranties of the Company


 

SECTION 3.01.

 

Organization, Standing and Power

   
A-5
 

SECTION 3.02.

 

Capital Structure

    A-6  

SECTION 3.03.

 

Company Subsidiaries; Equity Interests

    A-7  

SECTION 3.04.

 

Authority; Execution and Delivery; Enforceability

    A-8  

SECTION 3.05.

 

No Conflicts; Consents

    A-8  

SECTION 3.06.

 

SEC Documents; Undisclosed Liabilities; Internal Controls

    A-9  

SECTION 3.07.

 

The Proxy Statement

    A-11  

SECTION 3.08.

 

Absence of Certain Changes or Events

    A-11  

SECTION 3.09.

 

Taxes

    A-12  

SECTION 3.10.

 

Labor Relations

    A-13  

SECTION 3.11.

 

Employee Benefits

    A-13  

SECTION 3.12.

 

Title to Properties

    A-15  

SECTION 3.13.

 

Contracts

    A-15  

SECTION 3.14.

 

Litigation

    A-17  

SECTION 3.15.

 

Compliance with Laws

    A-17  

SECTION 3.16.

 

Regulatory Compliance

    A-18  

SECTION 3.17.

 

Environmental Matters

    A-20  

SECTION 3.18.

 

Intellectual Property

    A-21  

SECTION 3.19.

 

Insurance

    A-23  

SECTION 3.20.

 

Brokers and Other Advisors

    A-23  

SECTION 3.21.

 

Opinions of Financial Advisors

    A-23  

SECTION 3.22.

 

Affiliate Transactions

    A-24  


ARTICLE IV


 


Representations and Warranties of Parent and Merger Sub


 

SECTION 4.01.

 

Organization, Standing and Power

   
A-24
 

SECTION 4.02.

 

Merger Sub

    A-24  

SECTION 4.03.

 

Authority; Execution and Delivery; Enforceability

    A-24  

SECTION 4.04.

 

No Conflicts; Consents

    A-24  

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  Page  

SECTION 4.05.

 

Information Supplied

    A-25  

SECTION 4.06.

 

Available Funds

    A-25  

SECTION 4.07.

 

Brokers and Other Advisors

    A-25  

SECTION 4.08.

 

Ownership of Company Common Stock

    A-25  


ARTICLE V


 


Covenants Relating to Conduct of Business


 

SECTION 5.01.

 

Conduct of Business of the Company

   
A-26
 

SECTION 5.02.

 

No Solicitation; Adverse Recommendation Change

    A-29  


ARTICLE VI


 


Additional Agreements


 

SECTION 6.01.

 

Company Stockholders Meeting; Preparation of the Proxy Statement

   
A-32
 

SECTION 6.02.

 

Access to Information; Confidentiality

    A-33  

SECTION 6.03.

 

Reasonable Best Efforts; Notification

    A-33  

SECTION 6.04.

 

Communications and Interactions with Regulatory Authorities; Applicable Proceedings

    A-36  

SECTION 6.05.

 

Equity Awards

    A-36  

SECTION 6.06.

 

Continuing Employee Matters

    A-37  

SECTION 6.07.

 

Indemnification

    A-38  

SECTION 6.08.

 

Fees and Expenses

    A-39  

SECTION 6.09.

 

Public Announcements

    A-41  

SECTION 6.10.

 

Tax Matters

    A-41  

SECTION 6.11.

 

Stockholder Litigation

    A-41  

SECTION 6.12.

 

Section 16 Matters

    A-42  

SECTION 6.13.

 

Merger Sub and Surviving Corporation Compliance

    A-42  

SECTION 6.14.

 

Advice of Changes

    A-42  

SECTION 6.15.

 

Company Warrant

    A-42  

SECTION 6.16.

 

Company ESPP

    A-42  


ARTICLE VII


 


Conditions Precedent to the Merger


 

SECTION 7.01.

 

Conditions to Each Party's Obligation

   
A-43
 

SECTION 7.02.

 

Conditions to Obligations of Parent and Merger Sub

    A-43  

SECTION 7.03.

 

Conditions to Obligations of the Company

    A-44  


ARTICLE VIII


 


Termination; Amendment and Waiver


 

SECTION 8.01.

 

Termination

   
A-45
 

SECTION 8.02.

 

Effect of Termination

    A-46  

SECTION 8.03.

 

Amendment; Extension; Waiver

    A-46  


ARTICLE IX


 


General Provisions


 

SECTION 9.01.

 

Nonsurvival of Representations and Warranties

   
A-47
 

SECTION 9.02.

 

Notices

    A-47  

SECTION 9.03.

 

Definitions

    A-48  

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  Page  

SECTION 9.04.

 

Interpretation

    A-53  

SECTION 9.05.

 

Severability

    A-54  

SECTION 9.06.

 

Counterparts

    A-54  

SECTION 9.07.

 

Entire Agreement; Third-Party Beneficiaries; No Other Representations or Warranties

    A-54  

SECTION 9.08.

 

Governing Law

    A-55  

SECTION 9.09.

 

Assignment

    A-55  

SECTION 9.10.

 

Specific Enforcement; Jurisdiction

    A-55  

SECTION 9.11.

 

WAIVER OF JURY TRIAL

    A-56  

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INDEX OF DEFINED TERMS

Defined Term
  Location of
Definition
ABX License Agreements   9.03
Acceptable Confidentiality Agreement   9.03
Adverse Recommendation Change   5.02(e)
affiliate   9.03
Agreement   Preamble
Anti-Corruption Laws   3.15(d)
Applicable Proceeding   6.04(b)
Appraisal Shares   2.01(d)
Authorizations   3.15(b)
Bankruptcy and Equity Exception   3.04(a)
Book-Entry Shares   2.02(b)
Burdensome Condition   6.03(c)
Business Day   9.03
Certificate of Merger   1.03
Certificates   2.02(b)
Closing   1.02
Closing Date   1.02
Code   3.09(f)
Company   Preamble
Company Acquisition Agreement   5.02(a)
Company Balance Sheet   3.06(d)
Company Benefit Plan   9.03
Company Board   Recitals
Company Bylaws   3.01
Company Charter   3.01
Company Common Stock   Recitals
Company Disclosure Letter   Article III
Company ESPP   9.03
Company Intellectual Property   3.18(b)
Company Material Adverse Effect   9.03
Company Operating Plan   5.01(a)(v)
Company Preferred Stock   3.02(a)
Company Recommendation   3.04(b)
Company Registered Intellectual Property   3.18(a)
Company RSU   9.03
Company SEC Documents   3.06(a)
Company Stock Option   9.03
Company Stock Plans   9.03
Company Stockholder Approval   3.04(b)
Company Stockholders Meeting   6.01(a)
Company Subsidiaries   3.03(a)
Company Takeover Proposal   9.03
Company Termination Fee   6.08(b)
Company Warrant Agreement   9.03
Company Warrant   9.03
Confidential Disclosure Agreement   6.02
Consent   3.05(b)

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Defined Term
  Location of
Definition
Continuing Employees   6.06(a)
Contract   9.03
control   9.03
Controlled Group   3.11(d)
Copyrights   9.03
Current Offering Period   6.16
DGCL   Recitals
DOJ   6.03(d)
Drug Law   9.03
Effective Time   1.03
EMA   3.16(a)
Environmental Authorizations   3.17(a)
Environmental Claims   3.17(b)(i)
Environmental Law   3.17(b)(ii)
Equity Interests   3.02(a)
ERISA   3.11(c)
Exchange Act   9.03
Exchange Fund   2.02(a)
Excluded Shares   2.01(b)
Exercise Price   6.05(a)(i)
FCPA   3.15(c)
FDA   3.16(a)
FTC   6.03(d)
GAAP   3.02(e)
Good Clinical Practice Requirements   9.03
Good Laboratory Practice Requirements   9.03
Good Manufacturing Practice Requirements   9.03
Governmental Entity   3.05(b)
Hazardous Materials   3.17(b)(iii)
Health Care Submissions   3.16(a)
HSR Act   3.05(b)
Inactive Pharmaceutical Products   9.03
Indebtedness   9.03
Indemnified Persons   6.07(a)
Initial Extension Date   8.01(b)(i)
Intellectual Property   9.03
Intervening Event   9.03
IT Assets   9.03
Judgment   3.05(a)
knowledge   9.03
Law   3.05(a)
Lease   3.12(b)
Leased Real Property   3.12(b)
Legal Restraints   7.01(a)
Liens   9.03
Measurement Date   3.02(a)
Merger   Recitals
Merger Consideration   2.01(c)
Merger Sub   Preamble

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Defined Term
  Location of
Definition
Nasdaq   3.02(e)
Nonqualified Deferred Compensation Plan   3.11(i)
Notice of Adverse Recommendation Change   5.02(f)
OSS   9.03
Outside Date   8.01(b)(i)
Parent   Preamble
Parent Expenses   6.08(c)
Parent Material Adverse Effect   9.03
Parent Termination Fee   6.08(d)
parties   Preamble
party   Preamble
Patents   9.03
Paying Agent   2.02(a)
Permitted Antitrust Action   6.03(c)
Permitted Liens   9.03
Permitted Product   6.03(c)
Person   9.03
Personal Data   9.03
Pharmaceutical Products   9.03
PMDA   3.16(a)
Proceeding   3.14
Proxy Statement   3.05(b)
Qualifying Company Takeover Proposal   5.02(c)
Recent SEC Reports   Article III
Release   3.17(b)(iv)
Representatives   5.02(a)
Required Regulatory Approvals   9.03
Sanctions   3.15(c)
Sarbanes-Oxley Act   3.06(b)
SEC   9.03
Section 262   2.01(d)
Section 721   3.05(b)
Securities Act   9.03
Special Committee   Recitals
Specified Contract   3.13(a)
subsidiary   9.03
Superior Proposal   9.03
Surviving Corporation   1.01
Tax Return   9.03
Taxes   9.03
Taxing Authority   9.03
Trade Secrets   9.03
Trademarks   9.03
Transactions   Recitals
Transfer Taxes   6.10(c)
Voting Company Debt   3.02(c)

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        WHEREAS, the parties intend that at the Effective Time, Merger Sub will be merged with and into the Company (the "Merger") upon the terms and subject to the conditions set forth in this Agreement and in accordance with the General Corporation Law of the State of Delaware (the "DGCL"), with the Company surviving the Merger and becoming a wholly owned subsidiary of Parent as a result of the Merger;

        WHEREAS, the special committee of the Company Board (the "Special Committee") has (i) determined that this Agreement, and the Merger and the other transactions contemplated hereby (collectively, the "Transactions"), are fair to and in the best interests of the Company and its stockholders, (ii) approved and declared advisable this Agreement and the Transactions, including the Merger, in each case on the terms and subject to the conditions set forth in this Agreement and (iii) recommended that the Company Board approve this Agreement and the Transactions, including the Merger, in each case on the terms and subject to the conditions set forth in this Agreement;

        WHEREAS, the Board of Directors of the Company (the "Company Board") (acting upon the affirmative recommendation of the Special Committee) has (i) determined that this Agreement and the Transactions, including the Merger, are fair to and in the best interests of the Company and its stockholders, (ii) approved and declared advisable this Agreement and the Transactions, including the Merger, in each case on the terms and subject to the conditions set forth in this Agreement and (iii) recommended that the holders of shares of common stock, par value $0.001 per share, of the Company ("Company Common Stock"), adopt this Agreement and directed that this Agreement be submitted for adoption by the Company's stockholders at the Company Stockholders Meeting;

        WHEREAS, the Board of Directors of Merger Sub has approved and declared advisable, and the Board of Directors of Parent has approved, this Agreement and the Transactions, including the Merger, in each case on the terms and subject to the conditions set forth in this Agreement; and

        WHEREAS, Parent, Merger Sub and the Company desire to make certain representations, warranties, covenants and agreements in connection with the Transactions.

        NOW, THEREFORE, the parties hereto agree as follows:


ARTICLE I

The Merger

        SECTION 1.01.    The Merger.     On the terms and subject to the conditions set forth in this Agreement and in accordance with the DGCL, Merger Sub shall be merged with and into the Company at the Effective Time. At the Effective Time, the separate corporate existence of Merger Sub shall cease and the Company shall continue as the surviving corporation (the "Surviving Corporation").


        SECTION 1.02.
    Closing.     The closing of the Merger (the "Closing") shall take place at the offices of Cravath, Swaine & Moore LLP, 825 Eighth Avenue, New York, New York 10019 at 10:00 a.m., New York City time, on a date to be specified and agreed by Parent and the Company, which date shall be no later than the third Business Day following the satisfaction (or, to the extent permitted by Law, waiver by the party entitled thereto) of the conditions set forth in Article VII (other than those conditions that by their nature are to be satisfied at the Closing, but subject to the satisfaction (or, to the extent permitted by Law, waiver by the party entitled thereto) of such

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conditions), or at such other place, time and date as shall be agreed in writing by the parties hereto. The date on which the Closing occurs is referred to in this Agreement as the "Closing Date".


        SECTION 1.03.
    Effective Time.     Prior to the Closing, Parent, Merger Sub and the Company shall prepare, and on the Closing Date, Parent, Merger Sub and the Company shall file with the Secretary of State of the State of Delaware, a certificate of merger (the "Certificate of Merger") executed in accordance with, and in such form as is required by, the relevant provisions of the DGCL, and shall make all other filings or recordings required under the DGCL to effectuate the Merger. The Merger shall become effective at such time as the Certificate of Merger is duly filed with such Secretary of State of the State of Delaware or at such other time as Parent and the Company shall agree and specify in the Certificate of Merger (the time the Merger becomes effective being referred to herein as the "Effective Time").


        SECTION 1.04.
    Effects of Merger.     The Merger shall have the effects provided in this Agreement and as set forth in Section 259 of the DGCL. Without limiting the generality of the foregoing, at the Effective Time, all of the property, rights, privileges, powers and franchises of the Company and Merger Sub will vest in the Surviving Corporation, and all debts, liabilities and duties of the Company and Merger Sub will become the debts, liabilities and duties of the Surviving Corporation.


        SECTION 1.05.
    Certificate of Incorporation and Bylaws.     Subject to Section 6.07, at the Effective Time, (a) the certificate of incorporation of the Surviving Corporation shall be amended and restated in its entirety to be identical to the certificate of incorporation of Merger Sub as in effect immediately prior to the Effective Time (except that references therein to the name of Merger Sub shall be replaced by references to Endocyte, Inc.), and (b) the bylaws of the Surviving Corporation shall be amended and restated in their entirety to be identical to the bylaws of Merger Sub as in effect immediately prior to the Effective Time (except that references therein to the name of Merger Sub shall be replaced by references to Endocyte, Inc.), in each case, until thereafter amended in accordance with applicable Law and the applicable provisions therein.


        SECTION 1.06.
    Directors and Officers.     (a) The directors of Merger Sub immediately prior to the Effective Time shall be the directors of the Surviving Corporation, until the earlier of their resignation or removal or until their respective successors are duly elected and qualified, as the case may be.

        (b)   The officers of the Company immediately prior to the Effective Time shall be the officers of the Surviving Corporation, until the earlier of their resignation or removal or until their respective successors are duly elected or appointed and qualified, as the case may be.


ARTICLE II

Effect on Capital Stock; Payment for Shares

        SECTION 2.01.    Effect on Capital Stock.     At the Effective Time, by virtue of the Merger and without any action on the part of Parent, Merger Sub, the Company or any holder of any shares of Company Common Stock or any shares of capital stock of Merger Sub:

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        SECTION 2.02.
    Payment of Merger Consideration.     (a) Paying Agent. Prior to the Effective Time, Parent shall select a bank or trust company reasonably acceptable to the Company to act as paying agent (the "Paying Agent") for the payment of the Merger Consideration as provided in Section 2.01(c). Parent shall take all steps necessary to enable and shall cause the Surviving Corporation to provide to the Paying Agent, on a timely basis, at or immediately after the Effective Time, cash necessary to pay for the shares of Company Common Stock converted into the right to receive the Merger Consideration pursuant to Section 2.01(c) (such cash being hereinafter referred to as the "Exchange Fund").


        (b)
    Exchange Procedure.     Promptly (and in any event no later than five Business Days) after the Effective Time, the Paying Agent shall mail to each holder of record of a certificate or certificates, or a non-certificated share or non-certificated shares, that immediately prior to the Effective Time represented outstanding shares of Company Common Stock (the "Certificates" or "Book-Entry Shares",

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respectively) which were converted into the right to receive the Merger Consideration pursuant to Section 2.01(c) (i) a letter of transmittal (which shall specify that delivery shall be effected, and risk of loss and title to the Certificates or Book-Entry Shares, as applicable, shall pass, only upon delivery of the Certificates or Book-Entry Shares, as applicable, to the Paying Agent, and shall be in customary form and have such other provisions as any party may reasonably specify) and (ii) instructions for use in effecting the surrender of the Certificates or Book-Entry Shares, as applicable, in exchange for the Merger Consideration. Upon (A) in the case of a Certificate, surrender of such Certificate to the Paying Agent for cancellation, together with such letter of transmittal, duly executed, and such other documents as may reasonably be required by the Paying Agent or (B) in the case of Book-Entry Shares, receipt of an "agent's message" by the Paying Agent (or such other evidence, if any, of the transfer as the Paying Agent may reasonably request), the holder of such Certificate or Book-Entry Share, as applicable, shall be entitled to receive in exchange therefor the Merger Consideration for each share of Company Common Stock theretofore represented by such Certificate or Book-Entry Share, as applicable, pursuant to Section 2.01(c), and the Certificate or Book-Entry Share, as applicable, so surrendered shall forthwith be canceled. In the event of a transfer of ownership of Company Common Stock that is not registered in the transfer records of the Company, payment may be made to a Person other than the Person in whose name the Certificate or Book-Entry Share, as applicable, so surrendered is registered, if such Certificate or Book-Entry Share, as applicable, shall be properly endorsed or otherwise be in proper form for transfer and the Person requesting such payment shall pay any transfer or other Taxes required by reason of the payment to a Person other than the registered holder of such Certificate or Book-Entry Share, as applicable, or establish to the reasonable satisfaction of Parent that such Tax has been paid or is not applicable. Until surrendered as contemplated by this Section 2.02, each Certificate or Book-Entry Share shall be deemed at any time after the Effective Time to represent only the right to receive upon such surrender the Merger Consideration in accordance with this Article II. No interest shall be paid or accrue on the cash payable upon surrender of any Certificate or Book-Entry Share.


        (c)
    No Further Ownership Rights in Company Common Stock.     The Merger Consideration paid in accordance with the terms of this Article II upon the surrender of any Certificate or Book-Entry Share shall be deemed to have been paid in full satisfaction of all rights pertaining to the shares of Company Common Stock that such Certificate or Book-Entry Share represented immediately prior to the Effective Time. After the Effective Time, there shall be no further registration of transfers on the stock transfer books of the Surviving Corporation of shares of Company Common Stock that were outstanding immediately prior to the Effective Time. If, after the Effective Time, any Certificates or Book-Entry Shares are presented to the Surviving Corporation or the Paying Agent for any reason, they shall be canceled and exchanged as provided in this Article II. No cash payment with respect to the Merger Consideration shall be paid to the holder of any unsurrendered Certificate or Book-Entry Share until the surrender of such Certificate or Book-Entry Share in accordance with this Section 2.02.


        (d)
    Termination of Exchange Fund.     Any portion of the Exchange Fund that remains undistributed to the holders of Certificates or Book-Entry Shares for one year after the Effective Time shall be delivered to Parent, upon demand, and any former holder of Company Common Stock entitled to payment of Merger Consideration who has not theretofore complied with this Article II shall thereafter look only to Parent for payment of its claim for Merger Consideration.


        (e)
    No Liability.     None of Parent, Merger Sub, the Surviving Corporation or the Paying Agent shall be liable to any Person in respect of any cash from the Exchange Fund delivered to a public official pursuant to any applicable abandoned property, escheat or similar Law. If any Certificate or Book-Entry Share has not been surrendered immediately prior to the date on which the Merger Consideration in respect of such Certificate or Book-Entry Share would otherwise escheat to or become the property of any Governmental Entity, any such Merger Consideration in respect of such Certificate or Book-Entry Share shall, to the extent permitted by applicable Law, become the property of the Surviving Corporation, free and clear of all claims or interest of any Person previously entitled thereto.

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        (f)    Investment of Exchange Fund.     The Paying Agent shall invest any cash included in the Exchange Fund, as directed by Parent, on a daily basis. Any interest and other income resulting from such investments shall be paid to Parent. No such investment or any loss thereon shall affect the amounts payable pursuant to this Article II. Parent shall take actions necessary to ensure that the Exchange Fund includes at all times cash in an amount sufficient for the Paying Agent to pay the Merger Consideration in accordance with this Agreement.


        (g)
    Lost Certificates.     If any Certificate shall have been lost, stolen or destroyed, upon the making of an affidavit of that fact by the Person claiming such Certificate to be lost, stolen or destroyed and, if required by the Paying Agent, or, if the undistributed portion of the Exchange Fund has been returned to Parent pursuant to Section 2.02(d), by Parent, the posting by such Person of a bond in such reasonable and customary amount as indemnity against any claim that may be made against it with respect to such Certificate, the Paying Agent or Parent, as applicable, shall deliver in exchange for such lost, stolen or destroyed Certificate the applicable Merger Consideration.


        (h)
    Withholding Rights.     Each of the Surviving Corporation, Merger Sub, Parent and the Paying Agent shall be entitled to deduct and withhold from the consideration otherwise payable pursuant to this Agreement such amounts as may be required to be deducted and withheld with respect to the making of such payment under any applicable Tax Law. Amounts so withheld and paid over to the appropriate Taxing Authority shall be treated for all purposes of this Agreement as having been paid to the Person in respect of which such deduction or withholding was made.


ARTICLE III

Representations and Warranties of the Company

        Except as (a) specifically disclosed in the reports, schedules, forms, statements and other documents filed or furnished by the Company with the SEC since January 1, 2016 and publicly available on the internet website of the SEC at least two Business Days prior to the date of this Agreement (other than any disclosures (i) contained in any section entitled "Risk Factors", except to the extent such information consists of factual historical or current statements, (ii) set forth in any "Forward-Looking Statements" disclaimer or (iii) that are cautionary, non-specific, predictive or forward-looking in nature) (the "Recent SEC Reports") (it being agreed that any matter disclosed in the Recent SEC Reports shall be deemed to qualify the Company's representations and warranties hereunder only to the extent that it is readily apparent from the face of such disclosure in such Recent SEC Report that such disclosure is applicable to such representations and warranties) or (b) set forth in the disclosure letter (with specific reference to the Section of this Agreement to which the information stated in such disclosure relates; provided that information contained in any section of the disclosure letter shall be deemed to be disclosed with respect to any other Section of this Agreement to the extent that it is readily apparent from the face of such disclosure that such information is applicable to such other Section of this Agreement) dated the date hereof and delivered by the Company to Parent and Merger Sub immediately prior to the execution of this Agreement (the "Company Disclosure Letter"), the Company represents and warrants to Parent and Merger Sub as follows:


        SECTION 3.01.
    Organization, Standing and Power.    The Company is duly organized, validly existing and in good standing (where applicable as a legal concept) under the laws of the jurisdiction in which it is organized and has full power and authority necessary to enable it to own, lease or otherwise hold its properties and assets and to conduct its business as presently conducted, except as has not had and would not reasonably be expected to have, individually or in the aggregate, a Company Material Adverse Effect. The Company has made available to Parent true, correct and complete copies of the certificate of incorporation of the Company, as amended to the date of this Agreement (as so amended, the "Company Charter"), and the bylaws of the Company, as amended to the date of this

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Agreement (as so amended, the "Company Bylaws"). The Company Charter and the Company Bylaws are in full force and effect, and the Company is not in violation of any of their provisions. The Company has made available to Parent true, correct and complete copies of the minutes (or, in the case of minutes that have not yet been finalized, drafts thereof) of all meetings of the stockholders of the Company, the Company Board and each committee of the Company Board (other than the Special Committee established for the purpose of evaluating the Transactions or any similar transaction), in each case held since January 1, 2016 and prior to the date hereof (which may be redacted to remove any deliberations with respect to the Transactions or any similar transaction).


        SECTION 3.02.
    Capital Structure.    (a) As of the date of this Agreement, the authorized capital stock of the Company consists of 100,000,000 shares of Company Common Stock and 10,000,000 shares of preferred stock, par value $0.001 per share (the "Company Preferred Stock"). At the close of business on October 16, 2018 (such date and time, the "Measurement Date"), (i) 81,759,272 shares of Company Common Stock were issued and outstanding, (ii) no shares of Company Preferred Stock were issued and outstanding, (iii) no shares of Company Common Stock were held by the Company in its treasury, (iv) 8,948,849 shares of Company Common Stock were reserved and available for issuance pursuant to the Company's 2007 Stock Plan and the Company's 2010 Equity Incentive Plan, of which (A) 5,312,681 shares of Company Common Stock were subject to outstanding Company Stock Options and (B) 1,077,001 shares of Company Common Stock were subject to outstanding Company RSUs, (v) 744,190 shares of Company Common Stock were reserved and available for issuance pursuant to the Company ESPP and (vi) 722,000 shares of Company Common Stock were subject to the Company Warrant. As of the Measurement Date, no (A) shares of capital stock or other voting securities of, (B) other equity or voting interests in, (C) securities convertible into or exchangeable for, or options, warrants or other rights to acquire or receive any, capital stock, voting securities or other equity interests in, or (D) stock appreciation rights, "phantom" stock rights, or other rights that give the holder thereof any economic or voting interest of a nature accruing to the holders of capital stock in (clauses (A), (B), (C) and (D), collectively, "Equity Interests"), the Company were issued, reserved for issuance or outstanding except as set forth in this Section 3.02(a). From and after the Measurement Date through the date of this Agreement, the Company has not (i) issued any Equity Interests or (ii) incurred any obligation to make any payments based on the price or value of any Equity Interests or dividends (or other distributions) paid thereon or revenues, earnings or financial performance or any other attribute of the Company, in each case other than pursuant to the Company Stock Options, Company RSUs, the Company Warrant and other purchase rights and stock awards granted pursuant to the Company Stock Plans, in each case that were outstanding as of the Measurement Date, and in accordance with their respective terms as in effect at such time.

        (b)   All issued and outstanding Equity Interests in the Company are, and at the time of issuance all Equity Interests in the Company that may be issued prior to the Effective Time, including all shares that may be issued pursuant to the Company Stock Plans and the Company Warrant, will be, duly authorized, validly issued, fully paid and nonassessable (to the extent applicable as a legal concept) and not subject to or issued in violation of any purchase option, call option, right of first refusal, preemptive right, subscription right or any similar right under any provision of the DGCL, the Company Charter, the Company Bylaws or any Contract to which the Company is, or, to the knowledge of the Company, a stockholder of the Company is, a party or otherwise bound.

        (c)   As of the date of this Agreement, there are no bonds, debentures, notes or other Indebtedness of the Company that may have at any time (whether actual or contingent) the right to vote, or that are convertible into or exchangeable for securities having the right to vote, on any matters on which holders of shares of Company Common Stock may vote ("Voting Company Debt") or any securities that are convertible into or exchangeable for, or options, warrants or other rights to acquire or receive any, Voting Company Debt.

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        (d)   As of the date of this Agreement, except for the Company Stock Options, Company RSUs, Company Warrant and issuances of Company Stock pursuant to the Company ESPP, in each case in accordance with their respective terms as in effect at such time, there are not any outstanding obligations of the Company to issue, deliver or sell, or cause to be issued, delivered or sold, any Equity Interests in the Company. As of the date of this Agreement, there are not any outstanding obligations of the Company to directly or indirectly redeem, repurchase or otherwise acquire any Equity Interests in the Company, except for (A) acquisitions of shares of Company Common Stock in connection with the surrender of shares of Company Common Stock by holders of Company Stock Options in order to pay the exercise price of such Company Stock Options, (B) the withholding of shares of Company Common Stock to satisfy Tax obligations with respect to Company Stock Options or Company RSUs or (C) the acquisition by the Company of Company Stock Options or Company RSUs in connection with the forfeiture of such awards, in each case in accordance with their respective terms. The Company is not party to any agreement with respect to the voting, transfer or registration of any capital stock or voting securities of, or other Equity Interests in, the Company. Except as contemplated by this Agreement, the Company is not party to any agreement pursuant to which any Person is entitled to elect, designate or nominate any director of the Company.

        (e)   All Company Stock Options and Company RSUs are evidenced by written award agreements, in each case substantially in the forms that have been made available to Parent, except that such agreements may differ from such forms with respect to the number of Company Stock Options and Company RSUs covered thereby and the exercise price (if applicable), vesting schedule and expiration date applicable thereto. Each Company Stock Option and Company RSU may, by its terms, be treated in accordance with Section 6.05. Section 3.02(e) of the Company Disclosure Letter sets forth a true, correct and complete list of all Company Stock Options and Company RSUs outstanding as of the Measurement Date, specifying, on a holder-by-holder basis, (i) the name of each holder, (ii) the number of shares of Company Common Stock subject thereto, (iii) the grant date thereof, (iv) the exercise price thereof and (v) the expiration or vesting date thereof, in each case to the extent applicable. With respect to each grant of Company Stock Options and Company RSUs, each such grant was (A) made in accordance with the terms of the applicable Company Stock Plan, the Exchange Act and all other applicable Laws, and the rules and regulations of The Nasdaq Stock Market LLC ("Nasdaq") and (B) properly accounted for in accordance with generally accepted accounting principles in the United States ("GAAP") in the financial statements (including the related notes) of the Company and disclosed in the Company SEC Documents in accordance with the Exchange Act and all other applicable Laws.

        (f)    Section 3.02(f) of the Company Disclosure Letter sets forth a true, correct and complete list of (i) the name of the holder of the Company Warrant and (ii) the number of shares of Company Common Stock subject thereto. The Company Warrant was issued pursuant to, and all the terms and conditions of the Company Warrant are evidenced by, the Company Warrant Agreement, a true, correct and complete copy of which has been made available to Parent. The Company Warrant may, by its terms, be treated in accordance with Section 6.15. As of the Measurement Date, before giving effect to any adjustments set forth therein, the warrant price of the Company Warrant is $1.39 per share of Company Common Stock.


        SECTION 3.03.
    Company Subsidiaries; Equity Interests.    (a) There are no subsidiaries of the Company. Any dissolution by the Company of any Person which was formerly a subsidiary of the Company (collectively, the "Company Subsidiaries") and which the Company dissolved prior to the date of this Agreement was performed in compliance with all applicable Law, and there is no continuing material liability or obligation of the Company in respect of any such Person or such dissolution, whether contingent or otherwise.

        (b)   The Company does not own, directly or indirectly, any capital stock, membership interest, partnership interest, joint venture interest or other Equity Interest in any Person. There is no Person

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whose results of operations, cash flows, changes in stockholders' equity or financial position are consolidated in the financial statements of the Company. The Company does not have any obligation to acquire any Equity Interest, or any agreement or commitment to provide funds to or make any investment (in the form of a loan, capital contribution or otherwise) in, any Person.


        SECTION 3.04.
    Authority; Execution and Delivery; Enforceability.    

        (a)   The Company has all requisite corporate power and authority to execute and deliver this Agreement and, subject to obtaining the Company Stockholder Approval, to consummate the Transactions. The execution, delivery and performance by the Company of this Agreement and the consummation by the Company of the Transactions have been duly authorized by all necessary corporate ac