OWNERSHIP PROFILE

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 47 339.08 23.83 19,562,475
Mutual Fund 53 70.39 4.39 3,607,093
Insider 2 5.98 0.31 253,242

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 18 184.76 10.15 8,330,863
Sellers 190 -1,450.49 74.34 -61,023,437
Net -- -1,265.73 64.19 -52,692,574

Concentration

Value ($MM) % O/S Shares
Total Inst. 339.08 23.83 19,562,475
Top 10 Inst. 312.80 21.82 17,913,434
Top 20 Inst. 333.90 23.52 19,310,190
Top 50 Inst. 339.08 23.83 19,562,475

Style

Holders Value ($MM) % Inst Shares Shares
Growth 5 8.83 0.45 370,417
Core Growth 4 8.82 0.45 367,911
Growth 1 0.01 -- 2,506
Index 1 4.50 0.23 187,377
Other 9 269.80 14.59 11,979,853
Broker Dealer 1 0.48 0.03 26,924
GARP 2 11.22 0.77 631,660
Hedge Fund 4 162.31 8.85 7,267,292
Specialty 1 0.20 0.01 8,360
VC/Private Equi 1 95.60 4.93 4,045,617
Value 9 3.08 0.23 184,919
Core Value 9 3.08 0.23 184,919

Location: Global Region

Holders % O/S Shares Share Change
North America 17 17.97 14,752,942 7,038,730
Europe 10 0.96 788,509 667,507
Asia 1 -- 707 11

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Magnetar Capital Partners LP 5,214,176 6.35 5,214,176 11/1/18
Sanderling Ventures 4,045,617 4.93 -- 11/14/18
Pension Fund of the Christian Church 2,758,063 3.36 -624,615 12/31/17
Cambridge Isotope Laboratories Inc 2,000,000 2.44 2,000,000 9/29/17
Great Point Partners, LLC 1,606,100 1.96 1,606,100 9/30/18
Nuveen LLC 631,643 0.77 364,671 9/30/18
Low (Philip S) 564,249 0.69 133,519 12/21/18
Water Island Capital, LLC 421,016 0.51 421,016 11/30/18
JPMorgan Asset Management U.K. Limited 362,300 0.44 362,300 12/31/18
Sherman Michael A 310,270 0.38 114,913 12/21/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Eventide Healthcare & Life Sciences Fund 1,314,000 1.60 964,000 9/30/18
Janus Henderson Global Life Sciences Fund (Ire) 442,442 0.54 442,442 9/30/18
Arbitrage Fund 379,946 0.46 379,946 11/30/18
JPMorgan Funds - Systematic Alpha Fund 362,300 0.44 362,300 10/31/18
Fidelity Small Cap Index Fund 195,378 0.24 19,091 10/31/18
MSCI Emerging Markets Invesco ETF 187,377 0.23 187,377 10/31/18
TD Health Sciences Fund 124,931 0.15 124,931 6/30/18
Invesco All Cap Market Neutral Fund 86,900 0.11 86,900 4/30/18
CREF Stock Account 83,158 0.10 -4,669 11/30/18
iShares Russell 2000 Small-Cap Index Fund 55,655 0.07 7,430 9/30/18

* Insider values reflect direct beneficial ownership.

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