OWNERSHIP PROFILE

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 117 117.41 64.43 30,847,882
Mutual Fund 38 17.43 9.69 4,639,650
Insider 17 5.15 3.38 1,618,912

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 53 57.73 28.22 13,512,815
Sellers 52 -11.38 6.85 -3,279,218
Net -- 46.35 21.37 10,233,597

Concentration

Value ($MM) % O/S Shares
Total Inst. 117.41 64.43 30,847,882
Top 10 Inst. 88.75 49.07 23,494,663
Top 20 Inst. 104.42 57.42 27,495,682
Top 50 Inst. 115.43 63.38 30,347,777

Style

Holders Value ($MM) % Inst Shares Shares
Growth 18 3.20 1.57 752,372
Aggressive Growth 2 1.27 0.62 297,154
Core Growth 12 1.79 0.87 417,279
Growth 4 0.15 0.08 37,939
Income 2 0.21 0.10 49,262
Income Value 1 0.21 0.10 49,162
Yield 1 -- -- 100
Index 11 14.98 7.31 3,500,857
Other 37 76.30 40.19 19,244,762
Broker Dealer 10 1.31 0.64 305,261
GARP 7 10.52 5.13 2,458,429
Hedge Fund 19 55.36 27.02 12,935,455
VC/Private Equi 1 9.11 7.41 3,545,617
Value 11 0.80 0.47 226,107
Core Value 6 0.55 0.35 167,062
Deep Value 5 0.25 0.12 59,045

Location: Global Region

Holders % O/S Shares Share Change
North America 91 55.67 26,656,980 11,847,010
Europe 4 0.40 190,866 190,810
Asia 2 0.01 2,816 --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Sanderling Ventures 3,545,617 7.41 -- 3/10/17
Partner Fund Management, L.L.C. 3,441,594 7.19 3,441,594 12/31/17
RA Capital Management, LLC 3,364,648 7.03 3,364,648 12/31/17
Pension Fund of the Christian Church 2,758,063 5.76 -624,615 12/31/17
Fidelity Management & Research Company 2,101,715 4.39 -342,377 12/31/17
D. E. Shaw & Co., L.P. 2,077,502 4.34 1,660,361 12/31/17
Cambridge Isotope Laboratories Inc 2,000,000 4.18 2,000,000 9/29/17
The Vanguard Group, Inc. 1,629,409 3.40 127,562 12/31/17
Perceptive Advisors LLC 1,451,700 3.03 1,451,700 12/31/17
BlackRock Institutional Trust Company, N.A. 1,124,415 2.35 787,215 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Fidelity Growth Company Fund 1,103,415 2.30 -31,800 12/31/17
Vanguard Total Stock Market Index Fund 1,048,698 2.19 23,400 1/31/18
iShares NASDAQ Biotechnology ETF 631,291 1.32 -13,533 1/31/18
Vanguard Extended Market Index Fund 496,104 1.04 -976 1/31/18
Fidelity Series Growth Company Fund 293,700 0.61 -11,500 12/31/17
Bridgeway Ultra-Small Company Market Fund 249,000 0.52 -- 12/31/17
Fidelity Extended Market Index Fund 169,216 0.35 32,603 12/31/17
iShares Core S&P Total U.S. Stock Market ETF 92,612 0.19 1,518 1/31/18
iShares Micro-Cap ETF 90,977 0.19 -1,976 1/31/18
Vanguard Institutional Total Stock Market Index Fund 56,479 0.12 -- 1/31/18

* Insider values reflect direct beneficial ownership.

Copyright Thomson Reuters Corporation