OWNERSHIP PROFILE

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 116 162.71 51.40 35,449,390
Mutual Fund 42 30.72 6.17 4,253,344
Insider 17 6.21 2.34 1,613,876

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 51 98.92 26.06 17,974,539
Sellers 39 -10.09 3.39 -2,338,836
Net -- 88.83 22.67 15,635,703

Concentration

Value ($MM) % O/S Shares
Total Inst. 162.71 51.40 35,449,390
Top 10 Inst. 123.03 38.67 26,670,248
Top 20 Inst. 145.90 45.77 31,565,892
Top 50 Inst. 160.43 50.62 34,910,940

Style

Holders Value ($MM) % Inst Shares Shares
Growth 17 3.13 1.06 729,118
Aggressive Growth 2 1.28 0.43 297,133
Core Growth 12 1.79 0.61 417,279
Growth 3 0.06 0.02 14,706
Income 2 0.21 0.07 49,262
Income Value 1 0.21 0.07 49,162
Yield 1 -- -- 100
Index 10 14.57 4.93 3,399,971
Other 39 79.37 28.37 19,563,306
Broker Dealer 10 1.31 0.44 305,261
GARP 9 13.59 4.03 2,776,973
Hedge Fund 19 55.36 18.76 12,935,455
VC/Private Equi 1 9.11 5.14 3,545,617
Value 11 0.82 0.33 226,357
Core Value 6 0.57 0.24 167,312
Deep Value 5 0.25 0.09 59,045

Location: Global Region

Holders % O/S Shares Share Change
North America 86 44.93 30,990,545 16,293,484
Europe 6 0.36 245,866 245,810
Asia 2 -- 3,045 229

Top Holders

Holder Shares Held % O/S Share Change Filing Date
VHCP Management, LLC 4,300,000 6.23 4,300,000 3/12/18
Sanderling Ventures 3,545,617 5.14 -- 3/10/17
Partner Fund Management, L.L.C. 3,441,594 4.99 3,441,594 12/31/17
RA Capital Management, LLC 3,364,648 4.88 3,364,648 12/31/17
Pension Fund of the Christian Church 2,758,063 4.00 -624,615 12/31/17
Fidelity Management & Research Company 2,101,715 3.05 -342,377 12/31/17
D. E. Shaw & Co., L.P. 2,077,502 3.01 1,660,361 12/31/17
Cambridge Isotope Laboratories Inc 2,000,000 2.90 2,000,000 9/29/17
The Vanguard Group, Inc. 1,629,409 2.36 127,562 12/31/17
Perceptive Advisors LLC 1,451,700 2.10 1,451,700 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,181,287 1.71 155,989 2/28/18
iShares NASDAQ Biotechnology ETF 821,015 1.19 176,191 3/31/18
Vanguard Extended Market Index Fund 751,078 1.09 253,998 3/31/18
Bridgeway Ultra-Small Company Market Fund 249,000 0.36 -- 12/31/17
Fidelity Extended Market Index Fund 169,216 0.25 -- 2/28/18
VALIC Co I Health Sciences Fund 125,349 0.18 125,349 2/28/18
Vanguard Institutional Total Stock Market Index Fund 92,379 0.13 35,900 3/31/18
iShares Micro-Cap ETF 90,483 0.13 -2,470 3/31/18
John Hancock Funds II - Health Sciences Fund 65,984 0.10 65,984 3/31/18
Fidelity Growth Company Fund 62,167 0.09 -1,041,248 2/28/18

* Insider values reflect direct beneficial ownership.

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