OWNERSHIP PROFILE

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 135 497.23 83.79 58,233,507
Mutual Fund 46 74.28 9.44 6,562,551
Insider 18 8.45 2.34 1,624,337

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 74 279.45 44.21 30,728,932
Sellers 53 -32.69 6.14 -4,264,067
Net -- 246.76 38.07 26,464,865

Concentration

Value ($MM) % O/S Shares
Total Inst. 497.23 83.79 58,233,507
Top 10 Inst. 308.91 51.00 35,442,424
Top 20 Inst. 423.95 71.64 49,788,053
Top 50 Inst. 481.81 81.36 56,543,434

Style

Holders Value ($MM) % Inst Shares Shares
Growth 13 8.32 1.32 915,530
Aggressive Growth 2 1.62 0.25 177,133
Core Growth 9 6.68 1.06 734,391
Growth 2 0.02 0.01 4,006
Income 5 0.65 0.10 66,243
Income Value 2 0.50 0.08 54,716
Yield 3 0.16 0.02 11,527
Index 12 49.31 7.76 5,396,429
Other 54 363.82 57.59 40,027,060
Broker Dealer 12 10.34 1.64 1,137,130
GARP 13 38.32 6.07 4,218,892
Hedge Fund 27 226.62 35.87 24,930,221
VC/Private Equi 2 88.54 14.02 9,740,817
Value 12 5.34 0.99 691,167
Core Value 8 4.86 0.92 636,386
Deep Value 4 0.47 0.08 54,781

Location: Global Region

Holders % O/S Shares Share Change
North America 101 77.33 53,742,179 26,959,747
Europe 9 0.97 671,264 451,498
Asia 3 -- 3,399 354

Top Holders

Holder Shares Held % O/S Share Change Filing Date
venBio Select Advisor LLC 5,695,200 8.19 5,695,200 3/31/18
Partner Fund Management, L.L.C. 4,367,448 6.28 925,854 3/31/18
VHCP Management, LLC 4,300,000 6.19 4,300,000 3/31/18
Sanderling Ventures 4,045,617 5.82 500,000 3/9/18
RA Capital Management, LLC 3,881,793 5.59 517,145 3/31/18
T. Rowe Price Associates, Inc. 3,109,800 4.47 3,069,800 3/31/18
Pension Fund of the Christian Church 2,758,063 3.97 -624,615 12/31/17
Deerfield Management Company, L.P. 2,627,540 3.78 2,627,540 3/31/18
The Vanguard Group, Inc. 2,379,164 3.42 749,755 3/31/18
Baker Bros. Advisors LP 2,277,799 3.28 1,190,476 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,461,968 2.10 3,570 5/31/18
Fidelity Select Biotechnology Portfolio 806,715 1.16 806,715 4/30/18
iShares NASDAQ Biotechnology ETF 784,048 1.13 -36,967 5/31/18
Vanguard Extended Market Index Fund 769,277 1.11 18,199 5/31/18
PowerShares DWA Healthcare Momentum Portfolio 420,034 0.60 420,034 4/30/18
Eventide Healthcare & Life Sciences Fund 350,000 0.50 350,000 3/31/18
Fidelity Extended Market Index Fund 255,619 0.37 -- 4/30/18
Fidelity Advisor Biotechnology Fund 249,815 0.36 249,815 4/30/18
FCP OP Medical Biohealth Trends 183,963 0.26 183,963 2/28/18
VALIC Co I Health Sciences Fund 160,649 0.23 160,649 3/31/18

* Insider values reflect direct beneficial ownership.

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