OWNERSHIP PROFILE

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 182 797.70 80.00 63,563,593
Mutual Fund 159 194.23 13.87 11,019,788
Insider 17 10.65 2.00 1,591,260

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 102 213.21 19.69 15,642,856
Sellers 77 -130.70 12.56 -9,978,973
Net -- 82.51 7.13 5,663,883

Concentration

Value ($MM) % O/S Shares
Total Inst. 797.70 80.00 63,563,593
Top 10 Inst. 499.42 49.68 39,473,283
Top 20 Inst. 662.10 66.78 53,057,241
Top 50 Inst. 756.18 76.21 60,552,171

Style

Holders Value ($MM) % Inst Shares Shares
Growth 30 16.13 1.47 1,168,156
Aggressive Growth 2 0.09 0.01 5,361
Core Growth 24 15.36 1.40 1,110,880
Growth 4 0.69 0.07 51,915
Income 5 3.73 0.33 266,100
Income Value 2 2.15 0.20 156,027
Yield 3 1.58 0.14 110,073
Index 21 173.83 15.84 12,588,693
Other 63 544.74 51.44 40,870,726
Broker Dealer 13 7.04 0.64 510,020
GARP 23 63.82 5.84 4,641,509
Hedge Fund 23 299.05 27.27 21,670,020
Specialty 1 0.13 0.01 8,360
VC/Private Equi 3 174.71 17.67 14,040,817
Value 16 13.30 1.23 978,216
Core Value 13 9.83 0.91 726,756
Deep Value 3 3.47 0.32 251,460

Location: Global Region

Holders % O/S Shares Share Change
North America 136 74.66 59,322,895 9,115,354
Europe 20 0.60 475,402 26,688
Africa 1 0.11 89,200 89,200
Asia 4 0.01 8,994 513

Top Holders

Holder Shares Held % O/S Share Change Filing Date
venBio Select Advisor LLC 5,695,200 7.17 -- 6/30/18
RA Capital Management, LLC 5,649,884 7.11 1,768,091 6/30/18
BlackRock Institutional Trust Company, N.A. 4,849,327 6.10 3,147,395 6/30/18
VHCP Management, LLC 4,300,000 5.41 -- 6/30/18
Partner Fund Management, L.L.C. 4,100,953 5.16 -266,495 6/30/18
Sanderling Ventures 4,045,617 5.09 500,000 3/9/18
The Vanguard Group, Inc. 3,130,131 3.94 750,967 6/30/18
Pension Fund of the Christian Church 2,758,063 3.47 -624,615 12/31/17
T. Rowe Price Associates, Inc. 2,619,809 3.30 -489,991 6/30/18
Deerfield Management Company, L.P. 2,324,299 2.93 -303,241 6/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,619,329 2.04 -- 8/31/18
iShares Russell 2000 ETF 1,361,567 1.71 -21,538 8/31/18
iShares NASDAQ Biotechnology ETF 811,059 1.02 2,877 8/31/18
Vanguard Extended Market Index Fund 807,428 1.02 12,608 8/31/18
iShares Russell 2000 Growth ETF 576,983 0.73 -11,080 8/31/18
Fidelity Select Biotechnology Portfolio 504,315 0.63 -177,000 7/31/18
SPDR S&P Pharmaceuticals ETF 431,571 0.54 8,152 8/31/18
Invesco DWA Healthcare Momentum ETF 422,003 0.53 -331,198 7/31/18
PowerShares DWA SmallCap Momentum Portfolio 357,214 0.45 357,214 7/31/18
Eventide Healthcare & Life Sciences Fund 350,000 0.44 -- 6/30/18

* Insider values reflect direct beneficial ownership.

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