Collaboration pairs leading SMDC technology with recognized CAR T-cell research expert
Plans to develop next generation CAR T-cell therapeutic platform with potential for improved safety and efficacy in solid tumor indications
aim of the research collaboration is to join Endocyte's SMDC bi-specific adaptor technology with the CAR T-cell immunotherapy research efforts at the
"This partnership brings together Dr. Jensen's expertise in the discovery and development of CAR T-cell therapies and Endocyte's SMDC
platform, with the aim of improving the efficacy and safety of CAR T-cell therapies and enabling them in solid tumor indications," said
"This collaborative project with
Research and development activities under the collaboration will be led by Dr.
About Endocyte's SMDC Bi-Specific Adaptors
Endocyte's SMDC bi-specific adaptors represent a novel approach that makes possible the engineering of a single universal CAR T-cell, designed to bind with high affinity to fluorescein isothiocyanate (FITC). This universal CAR T-cell can be specifically directed to cancer cells through the administration of a tumor targeted FITC-containing SMDC, known as a bi-specific adaptor, that acts to bridge the universal CAR T-cell with the cancer cells to cause localized T-cell activation. This technology may address or mitigate several challenges of current CAR T-cell therapies, such as i) the inability to control the rate of cytokine release and tumor lysis, ii) the absence of an "off switch" that can terminate cytotoxic activity when tumor eradication is complete, and iii) a requirement to generate a different CAR T-cell for each unique tumor antigen.
Forward Looking Statements
Certain of the statements made in this press release are forward looking, such as those relating to the company's development programs and upcoming milestones. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include risks that the company may experience delays in the completion of its clinical trials (whether caused by competition, adverse events, patient enrollment rates, shortage of clinical trial materials, regulatory issues or other factors); risks that data from its
clinical trials may not be indicative of subsequent clinical trial results; risks related to the safety and efficacy of the company's product candidates; risks that early stage preclinical data may not be indicative of subsequent data when expanded to additional preclinical models or to subsequent clinical data; risks that evolving competitive activity and intellectual property landscape may impair the company's ability to capture value for the technology; estimates of the potential markets for its product candidates; estimates of the capacity of manufacturing and other facilities required to support its product candidates; projected cash needs; and expected future revenues, operations, expenditures and cash position. More information about the risks and uncertainties faced by
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